Charles Waddell Chesnutt was an American author, essayist, political activist and lawyer, best known for his novels and short stories exploring complex issues of racial and social identity in the post-Civil War South. Two of his books were adapted as silent films in 1926 and 1927 by the African-American director and producer Oscar Micheaux. Following the Civil Rights Movement during the 20th century, interest in the works of Chesnutt was revived. Several of his books were published in new editions, and he received formal recognition. A commemorative stamp was printed in 2008.

Charles William Penrose was a member of the Quorum of the Twelve Apostles of the Church of Jesus Christ of Latter-day Saints from 1904 to 1911. Penrose was also a member of the First Presidency, serving as a counselor to church presidents Joseph F. Smith and Heber J. Grant from 1911 until his death.

Charles Wagner was a French reformed pastor whose inspirational writings were influential in shaping the reformed theology of his time.

Charles Warren Stoddard was an American author and editor best known for his travel books about Polynesian life.

Charles Wentworth Upham was a U.S. Representative from Massachusetts. Upham was also a member, and President of the Massachusetts State Senate, the 7th Mayor of Salem, Massachusetts, and twice a member of the Massachusetts State House of Representatives. Upham was the cousin of George Baxter Upham and Jabez Upham. Upham was later a historian of Salem and the Salem Witch Trials of 1692 when he lived there.

Charles Wesley Emerson (1837–1908) was the founder, namesake and first president of Emerson College in Boston, Massachusetts. Charles Emerson was also the author of a number of books dealing with oratory and a minister with the Unitarian Church.

Charles William Eliot was an American academic who was president of Harvard University from 1869 to 1909, the longest term of any Harvard president. A member of the prominent Eliot family of Boston, he transformed Harvard from a respected provincial college into America's preeminent research university. Theodore Roosevelt called him "the only man in the world I envy."

Charles William Heckethorn was a Swiss-born, naturalized British, author best known for his history of secret societies which was produced in two editions and translated into German, and his works relating to the history of London.

Charles William Russell was an Irish Roman Catholic clergyman and scholar.

Sir Charles Spencer Chaplin was an English comic actor, filmmaker, and composer who rose to fame in the era of silent film. He became a worldwide icon through his screen persona, the Tramp, and is considered one of the film industry's most important figures. His career spanned more than 75 years, from childhood in the Victorian era until a year before his death in 1977, and encompassed both adulation and controversy.