Francis Marion Crawford was an American writer noted for his many novels, especially those set in Italy, and for his classic weird and fantastical stories.

Francis Newton Thorpe (1857–1926) was an American legal scholar, historian, political scientist, and Professor of Constitutional History at the University of Pennsylvania.

Francis Parkman Jr. was an American historian, best known as author of The Oregon Trail: Sketches of Prairie and Rocky-Mountain Life and his monumental seven-volume France and England in North America. These works are still valued as historical sources and as literature. He was also a leading horticulturist, briefly a professor of horticulture at Harvard University and author of several books on the topic. Parkman wrote essays opposed to legal voting for women that continued to circulate long after his death. Parkman was a trustee of the Boston Athenæum from 1858 until his death in 1893.

Francis Perry Elliott was a writer and educator. Some of his works were adapted to film. His novel Pals First was staged and adapted into two films. Frederick Townsend Martin illustrated his book The Haunted Pajamas.

Francis Joseph Thompson was an English poet and Catholic mystic. At the behest of his father, a doctor, he entered medical school at the age of 18, but at 26 left home to pursue his talent as a writer and poet. He spent three years on the streets of London, supporting himself with menial labour, becoming addicted to opium which he took to relieve a nervous problem.

Francis Trevelyan Miller (1877–1959) was an American writer and filmmaker.

Francis Turner Palgrave was a British critic, anthologist and poet.

Francis William Newman was an English classical scholar and moral philosopher, prolific miscellaneous writer and activist for vegetarianism and other causes.

Francis William Sullivan, who wrote with the nom de plume Frank Williams, was an author. He wrote The Wilderness Trail a novel about the Hudson Bay area that was illustrated by Douglas Duer. It was made into the film The Wilderness Trail starring Tom Mix. The story was originally published in Photoplay Magazine as Glory Road and was followed by a sequel titled Star of the North.

Francisco Gómez de Quevedo y Santibáñez Villegas, Knight of the Order of Santiago was a Spanish nobleman, politician and writer of the Baroque era. Along with his lifelong rival, Luis de Góngora, Quevedo was one of the most prominent Spanish poets of the age. His style is characterized by what was called conceptismo. This style existed in stark contrast to Góngora's culteranismo.