Simeon Strunsky was a Russian-born Jewish American essayist and editorialist. He is best remembered as a prominent editorialist for the New York Times for more than two decades.

Simon Dubnow was a Jewish-Russian historian, writer and activist.

Simon Newcomb was a Canadian–American astronomer, applied mathematician, and autodidactic polymath. He served as Professor of Mathematics in the United States Navy and at Johns Hopkins University. Born in Nova Scotia, at the age of 19 Newcomb left an apprenticeship to join his father in Massachusetts, where the latter was teaching.

Harry Sinclair Lewis was an American novelist, short-story writer, and playwright. In 1930, he became the first author from the United States to receive the Nobel Prize in Literature, which was awarded "for his vigorous and graphic art of description and his ability to create, with wit and humor, new types of characters." Lewis wrote six popular novels: Main Street (1920), Babbitt (1922), Arrowsmith (1925), Elmer Gantry (1927), Dodsworth (1929), and It Can't Happen Here (1935).

Sir George Otto Trevelyan, 2nd Baronet, was a British statesman and author. In a ministerial career stretching almost 30 years, he was most notably twice Secretary for Scotland under William Ewart Gladstone and the Earl of Rosebery. He broke with Gladstone over the 1886 Irish Home Rule Bill, but after modifications were made to the bill he re-joined the Liberal Party shortly afterwards. Also a writer and historian, Trevelyan wrote his novel The Competition Wallah in around 1864, and The Life and Letters of Lord Macaulay, his maternal uncle, in 1876.

Sir Horatio Gilbert George Parker, 1st Baronet, known as Gilbert Parker, Canadian novelist and British politician, was born at Camden East, Addington, Ontario, the son of Captain Joseph Parker, R.A.

Snorri Sturluson was an Icelandic historian, poet, and politician. He was elected twice as lawspeaker of the Icelandic parliament, the Althing. He is commonly thought to have authored or compiled portions of the Prose Edda, which is a major source for what is today known as Norse mythology, and Heimskringla, a history of the Norse kings that begins with legendary material in Ynglinga saga and moves through to early medieval Scandinavian history. For stylistic and methodological reasons, Snorri is often taken to be the author of Egil's saga. He was assassinated in 1241 by men claiming to be agents of the King of Norway.

Solomon Northup was an American abolitionist and the primary author of the memoir Twelve Years a Slave. A free-born African American from New York, he was the son of a freed slave and a free woman of color. A farmer and a professional violinist, Northup had been a landowner in Washington County, New York. In 1841, he was offered a traveling musician's job and went to Washington, D.C. ; there he was drugged, kidnapped, and sold as a slave. He was shipped to New Orleans, purchased by a planter, and held as a slave for 12 years in the Red River region of Louisiana, mostly in Avoyelles Parish. He remained a slave until he met Samuel Bass, a Canadian working on his plantation who helped get word to New York, where state law provided aid to free New York citizens who had been kidnapped and sold into slavery. His family and friends enlisted the aid of the Governor of New York, Washington Hunt, and Northup regained his freedom on January 3, 1853.

Solon Robinson was a writer, journalist, agriculturist, and pioneer. He wrote for the New York Tribune and American Agriculturist and published several books including Hot Corn, a bestseller.

Sophie Jewett, also known under the pseudonym Ellen Burroughs, was an American lyric poet, translator, and professor at Wellesley College. Much of her poetry contains lesbian themes.