William Torrey Harris was an American educator, philosopher, and lexicographer. He worked for nearly a quarter century in St. Louis, Missouri, where he taught school and served as Superintendent of Schools for twelve years. With Susan Blow, in 1873 he established the first permanent, public kindergarten in the country. He is also known for establishing high school as an integral part of public education.

William Tyndale was an English biblical scholar and linguist who became a leading figure in the Protestant Reformation in the years leading up to his execution. He is well known as a translator of the Bible into English, and was influenced by the works of prominent Protestant Reformers such as Martin Luther.

William Vaughn Moody was an American dramatist and poet. Moody was author of The Great Divide, first presented under the title of The Sabine Woman at the Garrick Theatre in Chicago on April 12, 1906. His poetic dramas are The Masque of Judgment (1900), The Fire Bringer (1904), and The Death of Eve. His best-known poem is "An Ode in Time of Hesitation," on the Spanish-American War; others include "Gloucester Moor," "On a Soldier Fallen in the Philippines," "The Brute," "Harmonics", "Until the Troubling of the Waters," "The Departure," "How the Mead-Slave Was Set Free," "The Daguerreotype," and "The Death of Eve." His poems everywhere bespeak the social conscience of the progressive era (1893-1916) in which he spent his foreshortened life. In style they evoke a mastery of the verse-craft of his time and also the reach and depth derived from his intensive studies of Milton and of Greek tragedy.

William Walker Atkinson was an attorney, merchant, publisher, and author, as well as an occultist and an American pioneer of the New Thought movement. He is the author of the pseudonymous works attributed to Theron Q. Dumont and Yogi Ramacharaka.

Sir William Turner Walton was an English composer. During a sixty-year career, he wrote music in several classical genres and styles, from film scores to opera. His best-known works include Façade, the cantata Belshazzar's Feast, the Viola Concerto, the First Symphony, and the British coronation marches Crown Imperial and Orb and Sceptre.

William Watts Folwell was an educator, writer and historian who was the first president of the University of Minnesota.

William Wells Brown (November 6, 1814 – November 6, 1884) was an American abolitionist, novelist, playwright, and historian. Born into slavery near Mount Sterling, Kentucky, Brown escaped to Ohio in 1834 at the age of 19. He settled in Boston, Massachusetts, where he worked for abolitionist causes and became a prolific writer. While working for abolition, Brown also supported causes including: temperance, women's suffrage, pacifism, prison reform, and an anti-tobacco movement. His novel Clotel (1853), considered the first novel written by an African American, was published in London, England, where he resided at the time. It was later published in the United States.

William Wetmore Story was an American sculptor, art critic, poet, and editor.

William Whewell was an English polymath, scientist, Anglican priest, philosopher, theologian, and historian of science. He was Master at Trinity College, Cambridge. In his time as a student there, he achieved distinction in both poetry and mathematics.

Sir William Wilson Hunter was a Scottish historian, statistician, a compiler and a member of the Indian Civil Service.