SECOND PROVING.

First day.—(The drug was taken at half past seven in the evening.)

One hour after, violent headache, with painful lancinations. The pains continued all night, with sleeplessness.

Second day.130. The headache continues, especially at the temples and above the eyes. Acute pain at the elbow-joints. Taste of blood in the mouth. Rheumatic pain at the shoulder-blade. Repeated, violent lancinations in the right side of the abdomen. 135. Lancinations at irregular intervals, in the left shoulder-blade and muscles, from the left side of the chest. Headache all day. Constant dryness in the throat. Taste of blood in the mouth all day.

Third day.—Painful lancinations in the head, temples, and over the eyes. 140. Intense lancinating pains in the left side. Lancinations in the hypochondria and shoulder-blades. The pain at the elbow-joint continues. Lancination in the right knee-joint. Excessive heaviness and dulness of the head. 145. Constant drowsiness. Incessant headache. Intense, lancinating and constrictive pain in the muscles of the upper part of the right arm, for more than an hour. Continued formication in both feet, especially the left. Taste of blood in the mouth, as if blood had ascended in the throat, and had left the taste of it in the mouth. 150. Frequent and violent lancinations in the abdomen and bowels. Almost complete loss of appetite. Comatose, constantly drowsy. The head feels very heavy, with constant pain in it.

Fourth day.—No sleep at night. 155. The headache becomes intolerable. Taste of blood in the mouth. Attack of diarrhœa, with pain and tenesmus. First a natural stool, followed by frequent, painful discharges, first of black, fetid substances, then of a watery liquid; the attack lasts upwards of two hours. Lancination in the muscles of the right knee, also in the ribs and right side. 160. Pains in the hypochondria. Lancinating pain in the bowels. Lancinating pain in the left shoulder. The headache continues. Complete loss of appetite. 165. No sleep.