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In this Manual the 56 important problems of Hunter's Essentials of Biology are solved; that is, the principles of biology are developed from the laboratory standpoint. It is a teacher's detailed directions put into print. It states the problems, and then tells what materials and apparatus are necessary and how they are to be used, how to avoid mistakes, and how to get at the facts when they are found. Following each problem and its solution is a full list of references to other books.