FOOTNOTES:
[A] See also Labordine, p. [115]; Headache Cures, p. [305]; Anadol, p. [244]; Phenalgin, [335].
[B] See also Antikamnia, The Nostrum and Its Method of Exploitation, page [268].
[C] See also Phenalgin—A Typical Example, p. [335].
[D] See also Salacetin, p. [356].
[E] See also Tyree’s Antiseptic Powder, p. [404].
[F] For abstract of report on Ergoapiol see p. [82]; for the unabridged report of the Council’s action on Apergols, see Reports Council Pharm. and Chem., 1914, p. 64.
[G] For the unabridged report of the Council’s action on Betul-ol, see Reports Council Pharm. and Chem., 1914, p. 62.
[H] A reprint of various articles discussing Cactus Grandiflorus, Cactin—now called Cactoid—(Abbott Alkaloidal Company) and Cactina Pillets (Sultan Drug Company) will be sent on receipt of a 2-cent stamp.
[I] See also the reports on Wampole’s Preparation and Waterbury’s Compound, following this; also Hagee’s Cordial, p. [289]; The Comparative Nutrient Value of Cod Liver Oil and Cod Liver Oil Cordials, p. [442].
[J] See also reports on Hagee’s Cordial preceding and Waterbury’s Compound following this; also The Comparative Nutrient Value of Cod Liver Oil and Cod Liver Oil Cordials, p. [442].
[K] See also preceding reports on Hagee’s Cordial and Wampole’s Preparation; also Waterbury’s Compound once more, p. [291]; The Comparative Nutrient Value of Cod Liver Oil and Cod Liver Oil Cordials, p. [422].
[L] For the unabridged report of the Council’s action on Cystogen, Cystogen Aperient and Cystogen-Lithia, see Reports Council Pharm. and Chem., 1914, p. 66.
[M] Owing to lack of space a portion of the report is here omitted. A detailed discussion of these results is included in the full report contained in the reprint.
[N] For abstract of report on a similar mixture, see Apergols, p. [26]; for unabridged report of the Council’s action on Apergols and Ergoapiol see Reports Council Pharm. and Chem., 1914, p. 64.
[O] For the unabridged report of the Council’s action on Iodalia, see Reports Council Pharm. and Chem., 1914, p. 69.
[P] See also Burnham’s Soluble Iodine, p. [233].
[Q] For the unabridged report of the Council’s action on Iodotone, see Reports Council Pharm. and Chem., 1914, p. 72.
[R] For the unabridged report of the Council’s action on Nourry Wine, see Reports Council Pharm. and Chem., 1914, p. 74.
[S] For reports and articles on other acetanilid mixtures, see pp. [9], [244], [268], [305].
[T] See also Liquid Combinations Containing Pepsin and Pancreatin, p. [157]. A reprint of articles bearing on this subject, issued under the title Digestive Impossibilities, will be sent on receipt of a 2-cent stamp.
[U] See also following report on Valentine’s Meat Juice and article on Meat Extracts and Meat Juices, p. [470].
[V] See also preceding report on Meat and Beef Juices, and article on Meat Extracts and Meat Juices, p. [470].
[W] For articles on other viburnum preparations, see pp. [218] and [409].
[X] See also Bell-Ans (Papayans Bell), p. [282].
[Y] See also Pasadyne, p. [332].
[Z] See also Reexamination of Lactopeptine, p. [121]. A reprint of articles bearing on this subject is issued under the title Digestive impossibilities.
[AA] See also following reports on Clinical Experience with Liquid Paraffin (Liquid Petrolatum) and Angier’s Emulsion.
[AB] See also preceding report on Liquid Petrolatum or “Russian Mineral Oil” and following report on Angier’s Emulsion.
[AC] This investigation was made under the auspices of the Committee on Therapeutic Research of the Council on Pharmacy and Chemistry of the American Medical Association. At the request of the committee, Dr. W. A. Bastedo has prepared this critical review of the reports made by those who collaborated in this investigation.
[AD] See also preceding reports on Liquid Petrolatum or “Russian Mineral Oil” and Clinical Experience with Liquid Paraffin (Liquid Petrolatum).
[AE] For report on a similar compound, see Taurocol, p. [198].
[AF] See also report on Dioviburnia, p. [141], and article on Viburnum Compound and Other Nostrums, p. [409].
[AG] See also Anusol Suppositories, p. [280].
[AH] See also report on Burnham’s Soluble Iodine, p. [110]
[AI] See also report on Papayans Bell, p. [151].
[AJ] See also report on Hagee’s Cordial, p. [51].
[AK] See pp. [54], [57] and [442].
[AL] See also report on Acetanilid Mixtures, p. [9].
[AM] See also report on Passiflora and Daniel’s Tincture, p. [156].
[AN] For reports and articles on other coal-tar preparations, see pp. [9], [115], [244], [268], [305].
[AO] A reprint of articles on the subject of Phylacogens originally published in The Journal is issued under the title “The Phylacogens: A Menace to Rational Therapy.”
[AP] See also Medical Journals and Sanatogen, p. [431].
[AQ] See also report, p. [21].
[AR] See also Sanatogen, p. [358].
[AS] See also reports on Hagee’s Cordial, pp. [51], [289]; Wampole’s Preparation, pp. [52], [442], and Waterbury’s Compound, pp. [54], [57], [291].
[AT] A reprint of the letter from Parke, Davis & Co. referred to in this article, together with the discussion thereof, will be sent on receipt of a 2-cent stamp.
[AU] See Report of the Council on Pharmacy and Chemistry on “Meat and Beef Juices,” p. [123].
[AV] The so-called amorphous phosphorus is in reality a crystalline body and is more correctly called red phosphorus to distinguish it from the ordinary or yellow phosphorus. It is the ordinary or yellow phosphorus which is official as “Phosphorus.”
[1] This matter appears in “Nostrums and Quackery,” a 700-page book, and also in various pamphlets. Write for the descriptive price-list of publications dealing with the nostrum evil.
[2] From the circular accompanying a package bought over a year ago, we find the powder recommended for the following conditions: “For Leucorrhea, Gonorrhea, Vaginitis, Pruritus, Ulcerated conditions of the mucus membrane.... Scrofulous, Syphilitic and Varicose Ulcers ... for Spraying the Nose and Throat,... for immediate deodorizing and disinfecting ... for prickly heat, poison oak, squamous eczema and other conditions of similar nature.... As a deodorant and prophylactic in dental work,... for disinfecting offensive cavities ... for profuse and offensive perspiration, swelling, soreness and burning of the body and feet.... As a delightful toilet preparation after the bath and shaving.”
[3] Last January the national Food and Drugs Act went into effect; one of its provisions is that the label must not lie. This is not the exact verbiage, but it means the same thing. So, instead of repeating the old false statements, the new label of Tyree’s antiseptic powder contains nothing whatever about the composition; the law does not require that it should—unless the preparation contains certain specified drugs. Why is the formula omitted?
[4] Of Chionanthus Virginica or fringe-tree, the Council on Pharmacy and Chemistry in its 1912 report on “Some Unimportant Drugs” said: “The drug is much used by eclectics and homeopathists, especially as a depurant in hepatic and syphilitic disorders.... The claims for this remedy are not supported by experimental evidence and clinical reports of its use fail to show indications of discriminating critical observation. It is not noticed by most pharmacologic authorities.”
[5] The Journal A. M. A., July 9, 1887, p. 55.
[6] The Journal A. M. A., April 21, 1906, p. 1220.
[7] The Journal A. M. A., April 21, 1906, p. 1220.
[8] New York Med. Jour., 1891, liii, 681–683.
[9] Bull. gén. de thérap., 1891, cxxi, 343–349.
[10] Am. Pharm. Assn., 1906, liv, 405.
[11] The Journal A. M. A., Sept. 21, 1907, pp. 1021–1024.
[12] Practitioner, London, 1894, iii, 444–446.
[13] The Journal A. M. A., March 21, 1908, pp. 956–958.
[14] Practitioner, London, 1891, xlvii, 266–273.
[15] Med. Rec., New York, 1905, lxvii, 857.
[16] Practitioner, London, xlvii, 223; Therap. Gaz., 1890.
[17] See Unicorn Root, Wild Yam, and Wild Indigo, p. [208].
[18] See False Unicorn (Helonias), p. [84].
[19] The Journal A. M. A., Oct. 9, 1909, p. 1201.
[20] The Journal A. M. A., Oct. 9, 1909, p. 1201. (See following report, this volume.)
[21] Physicians who desire to use a solution of mercuric iodid in oil should direct their pharmacist to prepare it according to the method suggested by Lemaire (Repert. pharm., xxi, 97–102, from Chem. Abst., 1909, p. 1444), viz.: One gm. of mercuric iodid is dissolved in 50 c.c. sterilized castor oil by warming to about 70 degrees, 3 gm. guaiacol are added and the solution made up to 100 c.c. with sterilized poppy oil. Or according to a later suggestion (Dunning: Proc. Am. Pharm. Assn., 1910, p. 1123): one gm. of mercuric iodid is dissolved in 99 gm. of a mixture of equal parts of sterilized castor and olive oils, by warming on the water-bath.
[22] The Journal A. M. A., July 11, 1908, p. 140.
[23] New and Nonofficial Remedies, 1912, p. 68; The Journal A. M. A., April 15, 1911, Part 2, p. 18.
[24] Wohlgemuth: Biochem. Ztschr., March 18, 1912.
[25] The Journal A. M. A., Sept. 11, 1909, p. 869.
[26] These reports (A, first report on Digalen and B, examination of Digalen Tablets) will be published in the 1914 Annual Council Reports. A reprint of the entire matter dealing with the rejection of Digalen will be sent on receipt of a two-cent stamp.
[27] The Journal A. M. A., Sept. 11, 1909, p. 869.
[28] Cloetta: München. med. Wchnschr., 1904, No. 33.
[29] Kiliani: München. med. Wchnschr., 1907, p. 886.
[30] Kiliani: Am. Jour. Pharm., 1913, lxxxv, 224.
[31] Clinical Suggestions and Reports, December, 1912, p. 24.
[32] Advertisement Brit. Med. Jour., April 26, 1913.
[33] Hale: Hyg. Lab. Bull., 74.
[34] Veiel: München. med. Wchnschr., 1906, liii, 2140.
[35] Mueller: München. med. Wchnschr., 1909, lvi, 904.
[36] Eichhorst: Deutsch. med. Wchnschr., 1905, xxxi, 49.
[37] Teichmann: Therap. d. Gegenw., 1907, xlviii, 199.
[38] Eggleston, Cary, and Hatcher, Robert, A.: The Emetic Action of the Digitalis Bodies, The Journal A. M. A., Feb. 15, 1913, p. 499.
[39] Advertisement in Am. Med., January and February, 1913.
[40] Advertisement in Merck’s Arch., April, 1913.
[41] South. Medical Journal, January to May, 1913, inclusive.
[42] Advertisement in Brit. Med. Jour., April 26, 1913.
[43] Buechner: Pharm. Weekblad, March 2, 1912, p. 161.
[44] Bernheim and Dieupart: Revue Internationale de la Tuberculose, May, 1911, p. 336.
[45] Wall, C.: Brit. Med. Jour., July 20, 1912, p. 109.
[46] Zernik: Arb. a. d. Pharmazeut. Inst. d. Univ. Berlin, 1907, iv, 46.
[47] Therap. d. Gegenw., February, 1909.
[48] Phillips, John: Prevalence of the Heroin Habit, The Journal A. M. A., Dec. 14. 1912, p. 2146.
[49] Facts about Heroin, Current Comment, The Journal A. M. A., Dec. 21, 1912, p. 2262.
[50] The Formula for Glyco-Thymoline, Pharmacology Department, The Journal A. M. A., Jan. 9, 1909, p. 147.
[51] Puckner, W. A.: Rep. Chem. Lab., A. M. A., 1910, iii, 7.
[52] Verhoeff, F. H., and Ellis, Edward Keith: The Bactericidal Values of Some Widely Advertised Antiseptics, The Journal A. M. A., June 29, 1907, p. 2175.
[53] Feb. 2, 1907, p. 415, and Feb. 9, 1907, p. 521.
[54] The Journal A. M. A., July 4, 1914, p. 1.
[55] It should be noted that the discrepancies here reported between the actual and the claimed composition of Iodia were pointed out more than thirty years ago by A. B. Lyons (Detroit Lancet, October, 1882, vi, 157–8), who found that Iodia was deficient in iodid content and practically free from iron.
[56] Since this article was prepared we find that the national Food and Drugs Act has forced the proprietors of Labordine to put on the label the amount of acetanilid it contains, viz., 40 per cent., or 2 grains in a 5 grain tablet.
[57] Brunton, Sir Lauder: “Disorders of Assimilation, Digestion, etc.,” p. 183.
[58] Bull. No. 21, U. S. Dept. Agricult., Office of Experiment Stations.
[59] Five of these fluidextracts have their alcohol-content determined by the Pharmacopeia or National Formulary. Three are not recognized and hence their alcohol-content is not defined by law. The alcohol-content of the mixture of fluidextracts said to be in Dioviburnia has been kindly furnished by five leading pharmaceutical houses. If the lowest alcohol-content of the several fluidextracts is made the basis of calculation, Dioviburnia should contain at least 30.75 per cent. of alcohol, or more than half as much again as the amount declared on the label.
[60] Fussell, M. H.: Dangers of Certain Ethical Proprietary Preparations to Both Physicians and Public, The Journal A. M. A., Oct. 7, 1911, p. 1196.
[63] Med. Bull., 1898, xx, 457–464.
[64] Nashville Jour. Med. and Surg., 1897, lxxxi, 107–109.
[65] Detroit Med. Jour., 1904–5, lv, 17.
[66] Virginia Med. Semimonthly, 1898–9, iii, 392.
[67] The Journal, Sept. 23, 1905, p. 934.
[68] The Journal, Oct. 7, 1905, p. 1099.
[69] The Journal, April 6, 1907, p. 1197.
[70] Randolph, N. A.: Therap. Gaz., ix, 732.
[71] Randolph, N. A.: Proc. Acad. Nat. Sc., Philadelphia, 1884, p. 281.
[72] Robinson: William Duffield: Med. News, 1900, lxxvii, 56.
[73] Ewart, William: Brit. Med. Jour., 1902, ii, 1505.
[74] Schmidt, A. D.: München. med. Wchnschr., 1905, lii, 1970.
[75] Tyrode, Maurice Vejux: Boston Med. and Surg. Jour., 1910, clxii, 673.
[76] In addition to the articles referred to in the preceding footnotes, the following are of interest in connection with this subject:
Editorial, Therap. Gaz., 1885, ix, 353.
Junker, F. A.: Med. Record, London, 1885, xiii, 506.
Editorial, Med. News, 1886, xlviii, 105.
Dunbar: Deutsch. med. Wchnschr., 1896, xxii, 33.
Stubenrath, Franz Casimir: München. med. Wchnschr., 1897, xliv, 639.
London Letter, Med. News, 1899, lxxiv, 504.
Hutchison, Robert: Brit. Med. Jour., 1899, i, 724.
Schlesinger, E. G.: Boston Med. and Surg. Jour., 1913, clxix, 14.
Lane, W. Arbuthnot: Brit. Med. Jour., 1913, ii, 1126; Proc. Roy. Soc. Med., 1913, vi, 49; Surg. Gynec. and Obst., 1913, xvi, No. 6.
Jordan, Alfred C.: Practitioner, London, February, 1913.
Chrysospathes, J. G.: Zentralbl. f. Chir., 1913, No. 45; abstr., The Journal A. M. A., Dec. 13, 1913, p. 2201.
[77] Liquid Petrolatum or “Russian Mineral Oil,” p. [161].
[78] As is the custom in the exploitation of proprietary medicines, the preparation which is the firm’s main output—the leader—is made to do duty as an advertising medium for auxiliary preparations. Thus the Angier Emulsion booklet advises the use of Angier’s Throat Tablets. These tablets are alleged to be composed essentially of elm bark and petroleum, are claimed to “promote appetite and aid digestion,” and it is stated that “their healing action on all mucous surfaces makes them decidedly beneficial, not only to the pulmonary tract but on the digestive areas as well.” Angier’s Throat Tablets were examined in the Association’s Laboratory to determine the amount and kind of petroleum present in the tablets. Extraction of the tablets with ether yielded a petroleum product which resembled in every way the product obtained from the emulsion. Slightly less than 12 per cent. of the tablet was composed of the petroleum oil. The part insoluble in ether appeared to consist essentially of elm bark, with gum and sugar.
[79] The Journal A. M. A., March 26, 1910, p. 1071.
[80] Wentworth, A. H.: The Cause of Infantile Atrophy, Deduced from a Study of Secretin in Normal and Atrophic Infants, The Journal A. M. A., July 20, 1907, p. 204.
[81] Sweet, J. E., and Pemberton, R.: Experimental Observations on Secretin, Arch. Int. Med., February, 1908, p. 231.
[82] Moore, Edie and Abram: Biochem. Jour., 1906, i, 28; ibid., i, 446.
[83] Foster, N. B.: Cases of Diabetes Treated with Secretin, Jour. Biol. Chem., January, 1907.
[84] Dakin, H. D., and Ransom, C. C.: Treatment of Case of Diabetes with Secretin, Jour. Biol. Chem., January, 1907.
[85] Beveridge, J. Wallace: Secretin, Am. Jour. Gastro-Enterology, April, 1914, p. 170.
[86] Two weeks ago (Journal A. M. A., Sept. 1, 1906, p. 695) it was pointed out that the manufacturers now give this information, but in a wholly unnecessarily obscure form.
[87] That portion of the report describing the experiments on animals is here omitted. It was printed in full in The Journal and in the Report of the Council on Pharmacy and Chemistry, 1905–1908.
[88] The booklet on Somnos, “Somnos, a Pharmacological Report,” which is referred to here, contains a “Therapeutic Index to the Usefulness of Somnos.” We give below a list of diseases mentioned in this index to show the wide range of usefulness (?) that is claimed for this chloral compound. Abortions. Abscess—of brain, kidney, liver, tonsils, parotid gland, mediastinum; in appendicitis, glanders, perinephritic, retropharyngeal, pyemic, pelvic, ovarian. Somnos lessens pain and quiets nervous state. Tablespoonful, repeated once or twice. Use liberally. Alcoholism—full doses repeated often. Gives calm sleep. No blood changes like those produced by chloral. Anemias—progressive and secondary. Somnos has no deleterious action on blood as is common with other hypnotics. Aneurism. Angina. Apoplexy. Appendicitis. Arthritis. Arsenical poisoning. Arteriosclerosis. Asthma. Biliary colic, Bright’s disease. Carbuncle. Carcinoma. Catarrh. Cellulitis. Cerebrospinal fever. Chlorosis. Cholecystitis. Chordee. Chorea. Cirrhosis. Coccydynia. Colic. Colitis. Concussion. Confusional Insanity. Contusions. Convulsions. Coryza. Cough. Cramps. Cystitis. Delirium. Diabetes. Diarrhea. Diphtheria. Dropsy. Dysmenorrhea. Dyspnea. Ear. Emphysema. Empyema. Endocarditis. Endometritis. Epididymitis. Epilepsy. Erysipelas. Fevers. Fistula. Gallstones. Gastralgia or Gastrodynia. Gastritis. Gonorrhea. Goiter. Gout. Hallucinations. Hay fever. Headache. Heart Disease. Hemicrania. Hiccough. Hydronephrosis. Hydrophobia, Hydrothorax. Hyperesthesia. Hysteria. Indigestion. Inflammation. Insomnia. Kidney disease. Laryngitis. Liver abscess. Cirrhosis. Lobar pneumonia. Lockjaw. Locomotor ataxia. Lumbago. Mal de mere. Malarial fever. Meningitis. Migraine. Melancholia. Metritis. Morphinism. Muscular rheumatism. Myelitis. Myocarditis. Myositis. Nephritis. Nervous dyspepsia. Neuralgia, occipito-cervical, etc. Neurasthenia. Neuritis. Night sweats. Orchitis. Otitis media. Parethesia. Paralysis. Parotitis. Peliosis rheumatica. Pericarditis. Perimetritis. Perihepatitis. Perichondritis. Peritonitis. Pertussis. Petit mal. Pharyngitis. Phthisis. Pleurisy. Pneumonia. Post-epilepsy. Prolapsed uterus. Pseudo angina pectoris. Purpura. Rabies. Rheumatic fever. Salpingitis. Sarcoma. Scarlet fever. Smallpox. Spasms. Stomach. Stomatitis. Sunstroke. Tenesmus. Tetanus. Tonsillitis. Trauma. Trismus. Typhoid fever. Typhus fever. Ulcers. Urticaria. Varicella. Vomiting. Vulvitis. Yellow fever.
[89] The Journal A. M. A., April 20, 1907, reprinted in “Propaganda for Reform,” 8th Edition.
[90] Details of the quantitative analysis of “Anusol Hemorrhoidal Suppositories” appear in the annual report for 1909 of the Chemical Laboratory of the American Medical Association.
[91] U.S. Pharmacopeia, 8th revision, p. 334.
[92] Hemmeter, Diseases of the Stomach, Edition 3, p. 250.
[93] Details of this analysis appear in the annual report for 1910 of the Chemical Laboratory of the American Medical Association.
[94] Proc. Am. Pharm. Assn., 1903, li, 409.
[95] Details of the quantitative analysis of “Hydrocyanate of Iron—Tilden” appear in the annual report for 1909 of the Chemical Laboratory of the American Medical Association.
[96] Details of this analysis appear in the annual report for 1910 of the Chemical Laboratory of the American Medical Association.
[97] Details of this analysis appear in the annual report for 1910 of the Chemical Laboratory of the American Medical Association.
[98] Details of this analysis are published in the annual report for 1910 of the Chemical Laboratory of the American Medical Association.
[99] Details of this analysis are published in the annual report for 1910 of the Chemical Laboratory of the American Medical Association.
[100] Puckner, W. A.: Report of the Chemical Laboratory of the American Medical Association, iii, 7.
[101] The analytical details will be published in the annual report of the laboratory.
[102] These appear in the annual report for 1908 of the Chemical Laboratory of the American Medical Association; they were also published in full in Jour. Am. Chem. Soc., September, 1908; an outline of the analysis appeared in The Journal A. M. A., Aug. 29, 1908.
[103] Details of this analysis appear in the annual report for 1910 of the Chemical Laboratory of the American Medical Association.
[104] According to a report in the Allgemeine medizinische Central-Zeitung Jan. 6, 1912, p. 14.
[105] The Journal A. M. A., June 3, 1905; reproduced on page [9] of this book.
[106] Oct. 2, 1909; see p. [227] of this volume.
[107] The Harmful Effects of Acetanilid, Antipyrin and Phenacetin, by L. F. Kebler, Ph.G., M.D., chief Division of Drugs, Bureau of Chemistry, with the collaboration of Drs. F. P. Morgan and Philip Rupp, assistant chemists.
[108] The Journal A. M. A., March 25, 1911, pp. 901, 910.
[109] Pharm. Ztg., Oct. 14, 1908, p. 817.
[110] Narcotin is now known to possess very little physiologic effect.
[111] Of the opium alkaloids, laudanin and thebain possess the most powerfully tetanizing properties, but they are present in opium in too small quantities to produce any noticeable effect. Neither of these alkaloids is removed by the usual processes for “denarcotizing” opium.
[112] See The Journal A. M. A., June 24, 1905, p. 1997.
[113] Dunglison’s Dictionary: “Synthetic—In chemistry the formation of a more complex body by the union of simpler bodies.” Dorland’s Dictionary: “Synthesis—The artificial building up of a chemic compound by the union of its elements.” “Union” is not mixing.
[114] This sentence is not complete, but, of course, this is immaterial. Little things like an incomplete sentence do not count.
[115] Those who wish to study the action and use of this drug further will find references to articles in The Journal as follows: The Journal, Jan. 5, 1907, pp. 64 and 70; March 30, 1907, p. 1133; April 20, 1907, p. 1351; Nov. 21, 1908, p. 1782; Nov. 28, 1908, p. 1886. The first page mentioned discusses the introduction of phenolphthalein into medicine.
[116] The Journal, March 30, 1907, p. 1133.
[117] Bacterial Vaccine Therapy: Its Indications and Limitations, p. 37, reprinted from The Journal A. M. A., April 26 June 28, 1913, price 10 cents.
[118] Anderson, John F.: Some Unhealthy Tendencies in Therapeutics, The Journal A. M. A., July 4, 1914, p. 1.
[119] Vaughan, Victor C.: Protein Split Products in Relation to Immunity and Disease, 1913, p. 226.
[120] Hunt, Reid, and Seidell, Atherton: Commercial Thyroid Preparations and Suggestions as to the Standardization of Thyroid, The Journal A. M. A., Oct. 24, 1908, p. 1385.
[121] The Journal A. M. A., June 3, 1905; reproduced on page [10] of this book.
[122] Morison, C. B.: Rept. Conn. Agri. Exper. Station, 1912, p. 197.
[123] Osborne and Mendel: Jour. Biol. Chem., 1913, xv, 317.
[124] Technically, this is incorrect, as the company had inconspicuously stated in the “literature”—not on the label—that the preparation contained “extract of opium.”
[125] Oct. 20, 1906, and May 18, 1907.
[126] Details of the analysis appear in the annual reports of the Chemical Laboratory.
[127] The Journal A. M. A., July 16, 1910, p. 235.
[128] The Journal A. M. A., March 28, 1908, p. 1065.
[129] The Journal A. M. A., Jan. 1, 1910, p. 63.
[130] Phenacetin is listed at 33 cents an ounce, acetphenetidin at 98 cents a pound in quarter-pound lots.
[131] Full details of analysis are published in Volume V of the annual report of the Chemical Laboratory.
[132] “Specimen 1” is a specimen of the product regularly sold in this country. “Specimen 2” is a specimen of a product sold in England and whose resale in this country was prohibited by the manufacturers.
[133] The Journal A. M. A., Dec. 14, 1912, March 22, 1913, and April 5, 1913; see also p. [451], this book.
[134] Pages [10] and [335], this book.
[139] Nostrums and Quackery, Ed. 2, p. 589; page [31], this book.
[141] The Journal, March 29, 1913, p. 1013.
[143] Nostrums and Quackery, Ed. 2, p. 470; page [358], this book.
[144] Nostrums and Quackery, Ed. 2, p. 639; page [179], this book.
[145] U. S. Dispensatory, Ed. 19, p. 860.
[146] Osborne, T. B., and Mendel, L. B.: Jour. Biol. Chem., 1914, xvii, 401.
[147] Fraud and Deception Connected with So-Called Cod Liver Oil Preparations, The Journal A. M. A., Oct. 13, 1906, p. 1207.
[148] Osborne and Mendel have shown (Jour. Biol. Chem., 1913, xv, 311) that mixtures of purified protein, lard, starch and protein-free milk have been singularly efficient for a time in promoting growth of young rats. In from sixty to 100 days or more, however, normal growth stops; the animals may remain at constant weight for a few days, or grow very slowly, and then suddenly decline and die unless a change is made in the diet. The substitution of butter-fat, egg yolk fat, or cod liver oil for a portion of the lard in the ration, in the experiments of these authorities, brought prompt recovery and continuation of normal growth.
[149] In the tables “carbohydrates” is used as synonymous with “nitrogen-free extract.”
[150] A German Council on Pharmacy and Chemistry, Propaganda, The Journal A. M. A., July 27, 1912, p. 291; Current Comment, Aug. 10, 1912, p. 452. Reform in the Advertising of Proprietary Medicinal Articles, Berlin Letter, Dec. 7, 1912, p. 2081. Heubner, W.: Wünsche zur Reform des Arzneivertriebes, Therap. Monatsh., 1912, xxvi, No. 11; abstr., The Journal A. M. A., Dec. 14, 1912, p. 2195.
[151] Heubner: Die Arzneimittelkommission des deutschen Kongresses für innere Medizin, Therap. Monatsh., 1914, xxviii, 185.
[152] See Waterbury’s Compound, pp. 54, 57 and 291.
[153] Boddaert: Arch. de pharmacod., 1895, 2.
[154] Massol and Gamel: Jour. de pharm. et de chem., 1901, xiv, 337.
[155] The Journal A. M. A., May 23, 1914, p. 1675.
[156] Noé, J.: Action comparée du phosphore blanc et du phosphore rouge sur la matière vivante, Compt. rend. Soc. de biol., 1899, 105, i, 380.
[157] Thornton, E. Q.: The Advantages of Amorphous Phosphorus over the Official Form, Therap. Gaz., 1894, xxxv, 19. Tr. Pan. Am. Med. Congress, 1893, Washington, 1895, p. 1,438.
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Spelling inconsistencies:
quinin/quinine
soluble/solubile/soluable
glucosid/glucoside
peroxid/peroxide
oxid/oxide
Hydrastin/Hydrastine
small-pox/smallpox
protochlorid/protochloride
narcotin/narcotine
anilpyrine/anilipyrine
vender/vendor
chemic/chemical
strychnin/strychnine
pseudo-scientific/pseudoscientific
semi-secret/semisecret
beta-naphthol/betanaphthol
to-day/today
acetyl-salicylic/acetysalicylic
indorse/endorse
indorsement/endorsement
gm./Gm.
Spelling corrections:
folowing —> following
wafer —> water
Amedemin —> Anedemin
Prepration —> Preparation
he —> the
decription —> description
administation —> administration
oven —> even
test —> tests
constitutent —> constituent
iutensive —> intensive
accurary —> accuracy
Helionas —> Helonias
Phamacopeia —> Pharmacopeia
cancerns —> concerns
repiration —> respiration
commitee —> committee
ampoules —> ampules
fradulent —> fraudulent
Thp —> The
Diastate —> Diastase
diminshed —> diminished
acetphenentidin —> acetphenetidin
1,169 —> 1,669 (in table)
effciency —> efficiency
that —> than
thought —> bought
Furthemore —> Furthermore
bareley —> barley
acetphentidin –> acetphenetidin
prramidon —> pyramidon
valuless —> valueless
containg —> containing
American —> America
article —> articles
nessary —> necessary
out —> our
strotium —> strontium
sercretin —> secretin
radicles —> radicals
Speciment —> Specimen
atained —> attained
wo —> woe
wounders —> wonders
lives —> livers
matiére —> matière
Geseundhitslehrer —> Geseundheitslehrer
readibly —> readily
alkoloids —> alkaloids
is —> it
methol —> menthol
amyolytic —> amylolytic
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