PROPRIETARY VANADIUM PREPARATIONS
Report of the Council on Pharmacy and Chemistry on Products of Vanadium Chemical Co.: Vanadiol, Vanadioseptol, Phospho-Vanadiol, Vanadoforme, etc.
Vanadiol and preparations thereof, the products of the Vanadium Chemical Company, were submitted to the Council. After thorough investigation it was concluded that the company has not, and never has had, any reliable evidence for the therapeutic claims it has presented to the medical profession regarding these products. Accordingly the Council voted that the several products under consideration be not accepted for inclusion with New and Nonofficial Remedies. The findings of the Council having been submitted to the Vanadium Chemical Company and its reply considered, the Council authorized publication of the report which appears below.
W. A. Puckner, Secretary.
The Vanadium Chemical Company, Pittsburgh, Pa., submitted to the Council on Pharmacy and Chemistry for inclusion in New and Nonofficial Remedies the following products: Vanadiol, Vanadioseptol, Phospho-Vanadiol, Vanadium Solution for Intravenous and Hypodermic Use and Vanadoforme. At the same time, the company submitted statements and “literature” regarding the composition and therapeutic value of these products. The committee to which the matter was referred, after carefully considering both the matter presented and certain modifications in the advertising matter to which the company consented, reported that the evidence, especially that relating to the therapeutic value of the preparations, was insufficient to warrant the acceptance of the articles. Since the validity of therapeutic claims can be determined to a certain extent by experimental investigation, the Council decided to postpone final action until sufficient dependable evidence as to the therapeutic value had been submitted.
Accordingly, a series of questions was sent to the Vanadium Chemical Company for the purpose of learning on what pharmacologic evidence the therapeutic claims were based. After waiting several months, the information requested not being furnished, the Council took final action on the products. This action was based both on the evidence originally submitted and on the advertising matter being sent out by the company at the time.
Briefly, Vanadiol is said to contain a compound of vanadium with oxygen and chlorin, which gives up its oxygen to readily oxidizable substances, such as the blood. In addition to this compound it contains an oxidizing agent (sodium chlorate) which is said to serve as a source of oxygen, so that, according to the theory of the promoters, Vanadiol acts in the animal system as an oxygen-carrier.
The following is quoted from an advertising circular:
“Most thorough and conclusive physiological tests were made on guinea-pigs and other animals, which established undoubted evidence as to the truth of this theory.
“INFLUENCE
“Under the influence of Vanadiol and the other derivatives, the appetite is increased, there is greater ability to peptonize ingested proteid material, and, through the improvement in the assimilative powers and the checking of abnormal fermentations, leads to an increase in weight. A greater excretion of urea follows their use. Phagocytic action is promoted by an increase in the leucocytes. All phases of the elimination of waste materials are favored by the positive increase in the number of red blood corpuscles and the percentage of hemoglobin, hematogenesis being thereby rendered more perfect. The beneficent effect of nascent (active) oxygen, upon the red corpuscles and upon tissue cells of low vitality are matters of common knowledge. The results obtained from the vanadium derivatives are not drug effects, but are due to improved metabolism, which in turn is due to the removal of microbian toxins, and the general stimulation of cell activity.
“In a tubercular organism, the action of Vanadiol is two-fold. First, it acts as an antiseptic and antitoxin, combating the Koch bacilli and neutralizing their poison. Second, as a reconstituent of the economy, to which it furnishes nascent oxygen, fortifying the defenseless cells by the very element that is necessary to make them healthy and resistant.”
“In Anemia and Chlorosis, the blood cells lack oxygen, and in Neurasthenia the nerve cells are deficient. Vanadiol brings both blood and nerve cells from a condition of weakness and decay into vital energy, by furnishing them with active oxygen in a manner that had not been possible by any other medicine.”
“Vanadiol accelerates the work of digestion by producing HCl in small doses; it does not hinder the peptonization of albuminoids as do beta-naphthol, salicylic acid, boric acid, etc., when used as a stomachal antiseptic, but on the contrary it favors, by hydrochloric acid, the transformation of albuminoids into peptone without the assistance of pepsin. Thus, Vanadiol, when given to consumptives, favors the digestion of large amounts of proteid materials and causes oxidation of toxins of the stomach. The stomachic action is reflected in other parts of the organism by the stimulation of the chief functions; the pulse becomes stronger and muscular strength increases; and, last, but of greatest importance, is the tremendous increase which will be noted in the hemoglobin and the red cell count.”
“Phospho-Vanadiol, a combination of Vanadiol with an easily assimilable organic phosphorus, is an active accelerator of general nutrition with a special action on the nervous system.”
Such remarkable statements as these are past credence, certainly, unless they are supported by scientific evidence. And evidence, either in support or in contradiction of the claims made, could be obtained; for many of these actions, at least, are capable of proof by animal experimentation. The Vanadium Chemical Company was asked to furnish such proof but failed to do so. The inference is plain! The committee has concluded that the company has not, and never has had, any reliable evidence on which to base the therapeutic claims it has presented to the medical profession.
Here another fact should be noted. It is the connection shown in The Journal, June 22, 1912, of the general manager of the Vanadium Chemical Company, F. M. Turner, with a fraudulent obesity cure concern, the Dr. Turner Company of Syracuse, N. Y.
It seems, moreover, by all the evidence available, that F. M. Turner is not authorized to use the title M.D.; yet, under this title his name appeared on cards representing the Vanadium Chemical Company and under this title, also, he published an article in a medical journal recommending to the medical profession the use of Vanadiol. Later this article was distributed as an advertising circular by the Vanadium Chemical Company. Turner’s connection with the Dr. Turner Company is known and acknowledged by the Vanadium Chemical Company, yet it still retains him as general manager!
While there is not necessarily any direct relation between the personnel of a proprietary manufacturing company and the value of that company’s product, it is natural that the medical profession should view with distrust any concern managed by one who has previously been connected with such a fraud as the Turner obesity cure.
The committee therefore recommends that the preparations of the Vanadium Chemical Company be refused recognition, and that this report be authorized for publication.—(From The Journal A. M. A., Jan. 18, 1913.)