IODEX

At fairly frequent intervals physicians receive through the mail free samples of “Iodex,” a black ointment sent out in small, circular aluminum boxes. Iodex is sold by Menley and James, Ltd., New York City, under the claim that it is a preparation of free iodin,[252] minus the objectionable features that go with free iodin. The preparation was examined in the A. M. A. Chemical Laboratory in 1915, and found practically devoid of free iodin. The laboratory also reported that when 1 or 2 grams of Iodex was rubbed on the skin of the forearm on several subjects and the urine collected and tested for iodin, the results were negative. This disproved the claim that “thirty minutes after inunction [with Iodex] iodine can be found in the urine.”

The findings of the laboratory, which were summed up in a report (The Journal, June 19, 1915) of the Council on Pharmacy and Chemistry on Iodex, were essentially as follows:

1. The composition is incorrectly stated; the actual iodin content is only about half of that claimed.

2. The action of Iodex is not essentially that of free iodin, although that is the impression conveyed by the advertising.

3. The assertion that iodin may be found in the urine shortly after Iodex has been rubbed on the skin has been experimentally disproved.

At the time the laboratory reported its findings, it pointed out the obvious contradiction in the claim that Iodex is not only an “effective free iodine application without drawbacks” but also a means of “really efficient external iodine therapy without stain or irritation.” It is impossible to have free iodin present in sufficient quantities to be thera­peutically efficient and not get skin stains and irritation.

In a recent issue of the house organ, Pharmacal Advance, there was a large display advertisement of Iodex under the heading: “For prophylaxis and to ‘Double Cross’ Disease,” with the claims:

“Free Iodine.”
“Rub Through Skin.”
“Does Not Irritate nor Stain.”

On other pages of the same issue these claims appeared:

“There is no therapeutic virtue in Iodex which is not inherent—though often latent—in Free Iodine; and there is no virtue in Free Iodine which is not available in Iodex.”

“In Iodex all the beneficent properties of Iodine are emphasized and all its disadvantages are eliminated—in a word, Iodex is Pure Free Iodine presented thera­peutically active and efficient, ready for use in all conditions, with all the well-known powers of Free Iodine, but without the sequelæ of unpleasant effects, as irritation, corrosion, desquamation, staining, etc., which defeat the ends of treatment when ordinary preparations of Iodine are used. The fact that Free Iodine in the form of Iodex can now be used in rectal and vaginal treatment, without irritation, speaks volumes for its penetrability and bland action.”

These quotations are sufficient to show that the manufacturers of Iodex still persist in their claim that the product contains free iodin. In view of this, the A. M. A. Chemical Laboratory has again examined Iodex, having recently purchased specimens on the open market. It reports that Iodex gives no test for free iodin, or at most, but minute traces.

An interesting side-light on the methods of Menley and James is also brought out in the issue of Pharmacal Advance just quoted. Under a “department” misnamed “Book Reviews” the following appears:

“The Actions of Drugs.—Torald Sollmann, M.D. Published by W. B. Saunders Co., Philadelphia. This is a book of lectures designed for students in pharmacy and deals with the subject in plain and simple language. The author in his introduction has brought out the fact that over-counter prescribing is baneful both to the public and to the pharmacist himself. Among some of the interesting points brought out that Pharmacol Advance has always maintained, namely, that ‘Potassium iodid is not absorbed efficiently by the skin; hence the ointment of potassium iodid is unscientific.’

“We would especially call attention to Ungt. Iodi U. S. P., containing Potassium Iodid, used as a solvent for its iodin content. Accepting Sollmann’s statement, it is to be assumed that Ungt. Iodi U. S. P. has not 100 per cent. efficiency.”

Garbling statements from scientific works for the purpose of puffing proprietaries is not unusual in nostrum exploitation. The facts are that the statement in Sollmann’s book, introduced in the Menley and James house organ under the guise of a book review, appeared in a discussion of iodin compounds. In this the author points out that to obtain systemic iodid effects, it is irrational to apply iodin preparations externally. So far as the free iodin content of the official ointment of iodin is concerned, L. E. Warren (Reports of the A. M. A. Chemical Laboratory, 1917) has shown that even after more than six months this ointment still contains about 75 per cent. of the free iodin originally added. The official ointment (Unguentum Iodi, U. S. P.), therefore, so far as its free iodin content is concerned, is far superior to Iodex, which contains no iodin in its free state.—(From The Journal A. M. A., May 3, 1919.)