Neurosyphilis

by Elmer Ernest Southard; Harry C. Solomon

INDEX

• Abscess, tonsillar, associated with neurosyphilis, [250].
• Addison’s disease in juvenile paretic, [279].
• Agraphia, [101].
• Albumin test, [474].
• Allbutt, Clifford, [257].
• Alcoholism, chronic, [227].
• Alcoholic dementia, [237].
  • epilepsy, [229].
  • hallucinosis, [225].
  • pseudoparesis, [222], [223], [451].
• Allergie, [129], [204].
• Alzheimer, [428].
  • method, [472].
• Amboceptor, [477].
• Amnesia, [195].
• Anaphylaxis, [129].
• Anatomical formulae, [25].
• Antigens, [476].
• Aortic aneurysm, [35], [439].
• —— sclerosis, [41], [46], [135].
• Aphasia, [31], [43], [101], [262], [445].
• Apoplexy, [197].
• Argyll-Robertson pupil, [209], [212], [217], [291], [450].
  • as isolated symptom, [217].
  • in alcoholism, [214], [229].
• Arndt, Junius and, [249].
• Arsenobenzol, [375], [377], [389], [486].
• Arteriosclerosis, cerebral, [101].
  • not a contraindication to intensive salvarsan therapy, [359].
  • radial, [68].
• Ascending lesion, [23].
• Asymmetrical lesions, [19].
• Ataxia, [31], [223].
• Atheromatous degeneration, [35].
• Atrophy, cerebellar, [39].
  • cerebral, [47], [134], [205].
  • parenchymal, [41].
  • pontine, [39].
• Atypical case congenital neurosyphilis, [270].
• Ayer, J. B., [472].
• Ballet, [72].
• Barrett, A. M., [54], [175], [187], [212], [218], [219].
• Bechterew, [219].
• Binet and Simon, [304].
• Binet scale, [277].
• Birnbaum, [403].
• Blood pressure, high, [70], [262], [124].
• Bly, [252].
• Bonhoeffer, [404], [415], [417].
• Bordet, [427].
• Bratz, [278].
• Bruck test, [479].
• Bruck, C., [479].
• Bumke, [214].
• Canavan, [256].
  • and Southard, [70].
• Cell count, [471].
• Cerebral syphilis, see diffuse neurosyphilis.
• Cerebrospinal syphilis, see diffuse neurosyphilis.
• Cervical hypertrophic meningitis of Charcot, [56], [441].
• Chancre, extragenital, [75], [342].
• Character change, neurosyphilis, [314].
• Charcot, [60], [186].
• Choroiditis, [242].
• Christian, [407].
• Cimbal, [403].
• Civilization and syphilis, [76].
• Clinical evidences of syphilis, [131].
• Clouston, [158].
• Collins, Joseph, [145].
• Compensation in neurosyphilis, [309], [402], [456].
• Complement, [477].
• Conduct disorder, [38].
• Congenital syphilis, absence of stigmata, [318].
  • as cause of feeblemindedness, [159], [447].
  • involvement of nervous system in, [274].
• Congenital neurosyphilis, [270], [395].
  • resembling feeblemindedness, [272].
• Conjugal neurosyphilis, [263].
• Convulsions, [43], [101], [248], [362].
  • cause of in paretic neurosyphilis, [232].
  • in psychopathic subject with syphilis, [417].
• Corneal opacity, syphilitic, [234].
• Cotard, [73].
• Cotton, H. A., [472].
• Craig, C. B., [152], [196].
• Cramer, [125].
• Cranial neurosyphilis, [140].
  • tenderness, [139].
• Crises, gastric, [367].
• Cysts, ependymal, [59].
  • of softening, [27], [36], [54].
• Cytorrhyctes luis, [381].
• Dana, Charles L., [65], [77], [78].
• Dazed states, [264].
• Deafness, [63].
• Decompression, [138].
• Defective delinquent—diffuse neurosyphilis, [300], [455].
• Dejerine-Tinel, [61].
• Delinquency and juvenile neurosyphilis, [298].
• Delirium tremens, [332].
• Dementia, [137].
• Dementia paralytica, see paretic neurosyphilis.
• Dementia praecox, [74], [185], [247].
• Depression, [95], [126].
• Depressive drugs, [189].
• Diabetes, and neurosyphilis, [240].
  • insipidus, [190].
• Diabetic pseudoparesis, [238].
• Diarsenol, [377], [389], [391], [486].
• Differential diagnosis, alcoholism and neurosyphilis, [227], [231], [234], [236].
  • brain tumor, diabetic pseudoparesis and neurosyphilis, [238].
  • diffuse and paretic neurosyphilis, [165], [193], [247].
  • manic-depressive psychosis and neurosyphilis, [69].
  • multiple sclerosis and neurosyphilis, [253], [255].
  • neurasthenia and neurosyphilis, [65], [183].
  • senile arteriosclerotic psychosis and neurosyphilis, [262].
• Diffuse neurosyphilis, cerebrospinal syphilis, cerebral syphilis, spinal syphilis, [17], [80], [85], [97], [103], [122], [140], [183], [193], [300], [331], [342], [359], [433], [439], [443].
  • premonitory symptoms, [342].
  • prognosis, [80], [103], [124], [433], [443].
  • spinal fluid findings in, [348].
  • symptoms, [99].
  • treatment, [98], [103], [184], [302], [390].
  • treatment, results, [343].
• Diplopia, [50], [184], [253], [356].
  • causes, [140].
• Donath, [401], [403].
• Drastich, [407].
• Duco and Blum, [403].
• Dupré, [407].
• Dysdiadochokinesis, [231].
• Ehrlich, [184], [428], [429].
• Encephalitis, [27], [248].
  • disseminated, [218].
• Endarteritis, [220].
• Ependymal cysts, [59].
• Ependymitis, [40], [47], [49], [134].
• Epilepsy, [192].
  • alcoholic, [229].
  • brought out by syphilis, [415].
  • Jacksonian, [103].
  • parasyphilitic, [194].
  • relation to juvenile neurosyphilis, [277].
  • syphilitic, [103], [194].
  • syphilogenic, [415].
• Epileptic neurosis, [195].
• Erb’s syphilitic spastic paraplegia, [147].
  • treatment of, [148].
• Euphoria, [73].
• Excited states, [95].
• Exner, M. J., [416].
• Exophthalmic goitre, syphilitic (?), [205].
• Extraocular palsy, [140], [441].
• Eye changes in neurosyphilis, [257].
• Eye muscles, paresis of, [17], [50].
• Facial paralysis, [53].
• Families of neurosyphilitics, [275], [316], [318], [320], [373], [431], [457].
• Family of neurosyphilitic, normal-looking, but syphilitic, [318].
• Familial syphilis, [299], [306].
• Farrar, C. B., [411].
• Fearnsides, Head and, [21], [140], [150], [193], [217], [374], [378].
• Feeblemindedness, [395].
  • and congenital syphilis, [159].
• Fernald, W. E., [159], [273], [396].
• Fildes, McIntosh and, [129], [329].
• Focal changes, [221].
  • meningitis, [50].
  • softenings, pontine, [54].
• Fournier, [142], [222], [186], [194], [381].
• Franz, [357].
• Froissart, [413].
• Fugue, hysterical, [264].
• Garnier, [407].
• General paresis, see paretic neurosyphilis.
• Glands, [270].
• Gliosis, [39], [47], [49], [136], [180].
• Globulin, [229].
  • tests, [473].
• Glycosuria, [238], [241].
• Goddard, [397].
• Gold sol reaction, [247], [474].
  • in brain tumor, [100].
  • paretic, [85], [98].
  • paretic, other tests negative, [383], [385].
  • in purulent meningitis, [100].
  • syphilitic, [85], [98], [345].
• Graham, Thomas, [429].
• Grandiosity, [72], [295], [455].
• Graves, W. W., [157].
• Grilli, [407].
• Gross, [257].
• Gumma, see gummatous neurosyphilis.
• Gumma of tonsil, [250].
• Gummatous neurosyphilis, [53], [56], [137], [138], [140], [221], [362], [438].
• Hallucinations, [53].
  • in paretic neurosyphilis, [249].
• Hauptmann, [348].
• Head and Fearnsides, [21], [140], [150], [193], [210], [217], [374], [387].
• Headache, [53], [63], [122], [247], [352].
  • causes of, [209].
• Hecht, [399].
• Hemianopsia in neurosyphilis, [242].
• Hemiplegia, [31], [45], [80], [122], [262], [360].
  • causes of, [389].
• Hemitremor, [197].
• Heredity, neuropathic, [84].
• Herxheimer reaction, [152].
• Heubner, [427], [428].
• Hinton, W. A., [471].
• Huntington’s chorea, [258].
• Hutchinsonian teeth, [45].
• Hydrocephalus, [134], [306].
• Hyperreflexia, explanation of, [233].
• Hypochondriacal ideas, [133].
• Hysteria, [185], [301].
• Hysterical symptoms, [18].
• Incontinence, vesical in tabetic neurosyphilis, [144].
  • rectal, [56].
• Incubation period of neurosyphilis, [152].
• Infectiousness of neurosyphilis, [95].
• Insight, [95].
• Insomnia, [63].
• Intracranial pressure, [139], [362].
• Intraspinal lesions, [95].
• Intraspinous therapy, [122], [366], [486].
  • unpleasant results of, [366].
• Intraventricular injections, [389], [487].
• Involution-melancholia, [187].
• Iodine, untoward results, of, [363].
• Iritis, [17].
• Järisch-Herxheimer reaction, [72].
• Joffroy, [214].
  • and Mignot, [64].
• Junius and Arndt, [249].
• Juvenile neurosyphilis, [438], [447].
  • relation to epilepsy, [277].
• Juvenile paresis, see juvenile paretic neurosyphilis.
• Juvenile paretic neurosyphilis, juvenile paresis, [45], [154], [157], [272], [275], [298], [306], [440].
  • age of onset, [158].
  • and Addison’s disease, [279].
  • and delinquency, [298].
  • prognosis, [156], [158], [162], [273], [275].
  • treatment, [154], [161], [278], [299].
• Juvenile paretic neurosyphilis, with initial trauma, [306].
  • congenital amputation of toes in, [158].
• Juvenile tabetic neurosyphilis, [161], [447].
• Kaplan, [255], [471].
• Kéraval, [257].
• Key, [427].
• Knee-jerks, absence of, [223].
  • lively, [75].
  • return of, [24].
• Koefod, Solomon and, [243].
• Kolmer, [471].
• Kraepelin, [65], [66], [69], [88], [91], [95], [187], [225], [249].
• Krafft-Ebing, [84].
• Laignel-Lavastine, [413].
• Lange, C., [428], [429], [474].
• Lancinating pains, [92], [141].
• Lépine, [408], [413].
• Leptomeningitis, [47], [54], [135].
• Lewandowski, [210].
• Liability of paretic, [295].
• Lissauer’s paralysis, [38].
• Locomotor ataxia, see tabetic neurosyphilis.
• Long, [418].
• Lucke, Baldwin, [93], [144].
• Lues maligna, [250], [452].
• Lumbar puncture, untoward effects, [352].
  • treatment of, [354].
• Lüth, [278].
• Lymphocytosis, [23], [30], [40], [49].
• McDonagh, [381].
• McIntosh, Fildes and, [129], [329].
• Malaria, cerebral, simulation of paretic neurosyphilis, [245].
• Mallory and Wright, [472].
• Manic-depressive psychosis, [68], [71], [77], [187], [202], [291], [384], [442].
• Marie, Chatelin and Patrikios, [412].
• Marie, [408], [414].
• Martin, E. G., [313].
• Massary, de, [414].
• Mattauschek and Pilcz, [347].
• Medicolegal and Social, [454].
  • period of paretic neurosyphilis, [414].
• Meilhon, [407].
• Memory, failing, [63].
• Meningitis hypertrophica cervicalis of Charcot, [56].
  • sympathica, [19].
  • syphilitic, [103].
• Mercurialization, [98].
• Mercury, [58], [83], [85], [98], [148], [193], [235], [376], [377], [389], [391], [395], [486].
  • untoward results of, [363].
• Metasyphilis, [89].
• Metchnikoff and Roux, [427], [428].
• Microgyria, occipital, [47].
• Mignot, Joffroy and, [64], [66].
• Migraine, [19].
• Mitchell, H. W., [218].
• Mœbius, [429].
• Mott, F. W., [158], [257], [308], [396], [437].
• Multiple sclerosis, [253], [256].
  • relation of syphilis to, [254].
  • spinal fluid findings in, [254].
• Muscular atrophy, [149], [446].
  • syphilitic relation to amyotrophic lateral sclerosis, [150].
• Muscular weakness, [279].
• Myerson, A., [196].
• Nageotti, [428].
• Nausea, [63].
• Neisser, [399].
• Nerve trunk tenderness, [148], [234].
• Nervousness, [63].
• Nervous indigestion, [63].
• Neurasthenia, [63], [183].
• Neuritis, cranial, [51].
  • optic, [365].
  • root, [235].
  • syphilitic, [235].
• Neurorecidive, [152], [153], [184], [196], [235].
• Neuroses, relation of syphilis to, [186].
• Neurosyphilis, [187], [238], [240], [242].
  • aggravated on military service, [404].
  • atypical, [258], [346].
  • atypical case resembling hysterical fugue, [264].
  • dates, [428].
  • forms of, [20], [21], [28], [29], [95].
  • galloping, [328].
  • history of, [427].
  • incubation period, [152].
  • infectiousness of, [95].
  • laboratory findings in, [82].
  • latent, [142], [203].
  • lesions, [303].
  • lighted up by stress of military service, [412].
  • and marriage, [319].
  • prevention, [320].
  • onset, [64].
  • in primary stage, [186].
  • in secondary stage, [185], [283], [390].
  • in secondary stage, prognosis, [390].
  • in secondary stage, treatment, [153].
  • spinal, [23].
  • and the war, [399], [466].
• Nissl-Alzheimer method, [427].
• Noguchi, [381].
  • and Moore, [428], [429].
• Nonne, [82], [125], [152], [186], [195], [196], [214], [216], [235], [254], [265].
  • -Apelt test, [473].
• Numbness, [56].
• Nystagmus, [45], [253], [256], [279].
• Obersteiner, [249].
• Occupation-neurosis, [312].
• Ogilvie method, [487].
• Operation for gumma, [139].
• Optic atrophy, [256].
  • in juvenile paretic neurosyphilis, [154].
• Optic thalamus, syphilitic lesion of, [205].
• Osteitis, syphilitic, [311].
• Ozena, [350].
• Pains, [31].
• Pandy test, [474].
• Paralysis, [123].
  • recovery from, [342].
  • of respiration, [248].
• Paranoia, syphilitic, [225].
• Paraphasia, [19], [43].
• Paraplegia, [26], [30].
• Parasyphilis, [89].
• Paresis sine paresi, [126], [186], [204], [303], [445].
• Paresis, see paretic neurosyphilis.
• Paretic neurosyphilis, dementia paralytica, general paresis, softening of the brain, [37], [63], [68], [74], [78], [80], [85], [97], [131], [188], [192], [197], [199], [202], [227], [241], [262], [289], [295], [309], [314], [323], [338], [372], [375], [377], [382], [384], [386], [388], [392], [435], [440], [442].
  • adjuvant causes of, [414].
  • causing social complications, [289].
  • causes of death in, [197].
  • course, [85].
  • duration, [88].
  • forms, [95].
  • improvement, [377].
  • incidence among officers, [407].
  • incidence among soldiers, [402].
  • lesions of, [131].
  • “lighted up” by domestic stress in civil life, [420].
  • “lighted up” by “gassing,” [414].
  • mortality from, [89].
  • nomenclature, [88].
  • onset, [192].
  • pathology of, [436].
  • prognosis, [435], [444].
  • symptoms, [90], [131].
  • symptoms, mental, [87].
  • symptoms, physical, [86].
  • versus diffuse neurosyphilis, [165].
  • versus vascular neurosyphilis, [169], [172].
  • with very marked meningitis, [332].
  • with very marked brain atrophy, [335].
  • without mental symptoms, [315].
  • traumatic exacerbation, [310].
  • traumatic form, [308], [413].
  • traumatic, shell-shock, [401].
  • treatment of, [85], [370], [372], [377], [382], [384], [386], [388], [392].
  • treatment, results of, [351].
• Pensions for disabilities resulting from venereal disease, [409].
• Pensions for neurosyphilis, [411].
• Peripheral neurosyphilis, [19].
• Perivascular infiltration, [41].
• Pernicious anemia with spinal symptoms, [267].
• Petit mal attacks, [195].
• Pförringer, [61].
• Phobia, [67].
• Pilcz, Mattauschek and, [347].
• Pitres and Marchand, [421], [424].
• Plaut, [249], [348], [428].
• Plaut, Rehm and Schottmüller, [471].
• Plasmocytosis, [40], [49], [55].
• Pleocytosis, [23], [220], [247], [344].
  • effect of antisyphilitic treatment on, [244], [376].
  • in remissions, [243].
  • significance of, [243].
  • spinal fluid otherwise negative, [270].
• Polydipsia, [190].
• Polyuria, [190].
• Pontine hemorrhage, [219].
  • softening, [54].
• Posey and Spiller, [257].
• Potassium iodid, [58], [85], [98], [193], [222], [376], [377], [389], [486].
• Preparesis, [65], [77], [78].
• Prince, Morton, [195].
• Psammoma, [213].
• Pseudoneurasthenia, [66].
• Pseudoparesis, [449].
  • alcoholic, [222], [229], [451].
  • diabetic, [238].
  • senile, [263].
  • shell-shock, [421].
  • syphilitic, [223], [371].
• Pseudoparetic neurosyphilis, [222].
• Pseudotabes, shell-shock, [424].
• Psychogenic neurosyphilis, [189].
• Psychographic disturbance, [228].
• Psychopathic personality, [302].
• Ptosis, [350].
• Pupillary reaction, changes in, [261].
  • signs, [69].
• Pupils, Argyll-Robertson, see Argyll-Robertson pupils.
  • irregular, [79], [201].
  • normally reacting in paretic neurosyphilis, [199].
  • sluggish reaction to light, [188].
  • stiff as isolated symptom, [265].
• Purkinje cells, binucleate, [48].
• Putnam, James J., [19], [56].
• Pyramidal tract lesion, bilateral, [326].
  • sclerosis, [44].
• Quadriplegia in juvenile paretic neurosyphilis, [275].
• Quincke, [427], [428].
• Randsklerose, [24].
• Ravaut, [428].
• Ravaut, Sicard, Nageotti, Widal, [428].
• Rayneau, [407], [413], [414].
• Recovery, [77].
• Recurrences, [70].
• Redlich, [403].
• Régis, [73].
• Remissions, [122], [435], [445].
• Retardation, [187].
• Retention of urine, [56].
• Retinitis, hemorrhages, [365].
• Richards, R. L., [402], [404], [406], [409].
• Robertson, A. R., [59].
• Rod cells, [226], [297].
• Romberg sign, [141], [216], [279].
• Root-sciatica, syphilitic, [418].
• Rosenau, [471].
• Ross-Jones test, [473].
• “Rum fit,” [229].
• Ryder, Charles T., [42].
• Saddle-shaped nose, [210].
• Salivation, [98].
• Salmon, Thomas W., [89].
• Salvarsan, [75], [83], [85], [193], [222], [377], [389], [486].
  • provocative, [78], [79].
  • untoward results of, [363].
• Salvarsanized serum, [75].
• Schaudinn, [427], [429].
• Sciatic pain in neurosyphilis, [149].
• Seizures, [31], [64], [83], [103], [444].
  • causes of in paretic neurosyphilis, [194].
  • Jacksonian, [392].
  • minor, [392].
• Senile arteriosclerotic psychosis, [262].
• Sensitized cells, [478].
• Sérieux and Ducaste, [96].
• Shaikewicz, [404].
• Shanahan, [278].
• Sheep’s corpuscles, [477].
• Shock, [42], [81].
• Sicard, [428].
• Six tests, [80], [85].
  • in tabetic neurosyphilis, [141].
• Smith and Solomon, [479].
• Social cases, [454].
  • service, [232].
• Solomon, [142], [255].
  • and Koefod, [243].
  • Smith and, [479].
  • Southard and, [202], [303].
• Somnolence, [45].
• Southard, E. E., [48], [134], [212].
  • and Canavan, [70].
  • and Solomon, [202], [303].
  • and Taft, [397].
• Spasms, clonic, [326].
• Spastic hemiplegia in paretic neurosyphilis, [323].
• Spastic paraplegia, Erb’s, [147], [306].
• Spasticity, [18], [256].
• Speech defect, [69], [133].
• Spiller, [150].
  • Posey and, [257].
• Spinal fluid findings in secondary stage of syphilis, [151], [185], [283].
  • in juvenile paretic neurosyphilis, [275].
  • negative in diffuse neurosyphilis, [140].
  • negative in gummatous neurosyphilis, [138].
  • negative in neurosyphilis, [216].
  • negative in tabetic neurosyphilis, [269].
  • in tabetic neurosyphilis, [141].
• Spinal fluid, withdrawal for therapeutic purposes, [377], [379].
• Spinal syphilis, see diffuse neurosyphilis.
• Spirochetes, “drug fastness,” [381], [394].
  • strains, [76], [263], [276], [381], [394].
• Steida, [405].
• Sterility in tabetic neurosyphilis, [144].
• Stier, [407].
• Stokes, Wile and, [186].
• Suicide, [92], [126], [240], [296], [301].
• Summary, [427].
• Syphilis aggravated by service, [406], [411].
  • on service, [409].
• Syphilis as cause of diabetes, [241].
  • as cause of feeblemindedness, [396].
  • hereditaria tarda, [160], [318].
  • history of, [427].
  • lesions in, [329].
  • of lung, [211].
  • from Mongolian, [76].
  • primary, [65].
  • secondary, [65].
  • tertiary, lesions in, [329].
• Syphilitic feeblemindedness, pathology of, [160].
  • neuritis, [312].
  • psychosis, [91].
• Syphilophobia, [67], [361].
• Syphilotoxins, [72].
• Swift, [129], [212].
• Swift and Ellis, [428], [429].
  • method, [428], [487].
• Tabes dorsalis, see tabetic neurosyphilis.
• Tabetic neurosyphilis, tabes dorsalis, locomotor ataxia, [30], [31], [141], [146], [366], [367], [434], [446].
  • associated with cerebral symptoms, [177].
  • atypical, [143].
  • cervical, [146].
  • course, [141].
  • with negative spinal fluid findings, [269].
  • prognosis, [94].
  • shell-shock, [403].
  • “shell-shocked” into paretic neurosyphilis, [401].
  • symptoms, [93].
  • symptoms in order of frequency, [145].
  • treatment, [145], [366], [367].
  • plus vascular neurosyphilis, [175].
  • with vascular insult, [30], [439].
  • versus pernicious anemia, [267].
• Taboparesis, see Taboparetic neurosyphilis.
• Taboparetic neurosyphilis, taboparesis, [92], [135], [195], [284], [443].
  • course, [92].
  • nomenclature, [94].
  • prognosis, [92], [443].
  • and typhoid meningitis, [284].
• Taft, A. E., Southard, E. E., and,
• Talon, [407].
• Taylor, E. W., [50].
• Temperature, paretic, [376].
• Tests, changes under treatment, [102].
  • changed to negative in paretic neurosyphilis without clinical improvement, [385].
  • changed to less strongly positive in paretic neurosyphilis without clinical improvement, [386].
• Therapeutic conception, [324].
• Thibierge, [399].
• Thierry, [158].
• Throbbing in head, [63].
• Thrombosis, cerebral, [36], [42], [342], [357], [360], [124].
• Thymus, persistent, [282].
• Tibial exostoses, [100].
• Tigges’ formula, [248].
• Todd, J. L., [406], [409].
• Transient deafness, [18].
  • blindness, [18].
  • paralysis, [124].
  • paralysis, condition in which occurs, [123].
• Trauma and juvenile neurosyphilis, [278], [306].
  • neurosyphilis, [456].
  • paretic neurosyphilis, [199], [308], [310].
  • syphilitic osteitis, [311].
• Treatment of neurosyphilis, [67], [75], [83], [124], [148], [184], [222], [235], [299], [328], [332], [335], [342], [346], [350], [351], [355], [384], [390], [392], [395], [419], [439], [457].
  • case in which theoretically of no avail, [323].
  • methods, [356], [486].
• Treatment of syphilis, effect on development of neurosyphilis, [142], [347].
• Tremor, [197].
  • intention, [256]
• Tubercle, [80].
• Tuberous sclerosis of Bourneville, [47].
• Tumor, cerebral, [53], [191], [238], [253].
  • pineal, [213].
• Unconsciousness, [53].
  • causes of, [389].
• Vascular changes, [220].
• Vascular neurosyphilis, [31], [42], [72], [296], [359], [433], [440].
  • plus tabetic neurosyphilis, [175].
  • prognosis, [433].
  • versus paretic neurosyphilis, [169], [172].
• Veeder, B. S., [274].
• Vertigo, [122].
• Viet, [278].
• Virchow, [427], [428].
• Vomiting, [53], [63].
• Warthin, [241].
• Wassermann reaction, [191].
  • and alcoholism, [230].
  • in congenital syphilis, [160], [271].
  • meaning of “doubtful,” [360].
  • negative in diffuse neurosyphilis, [184].
  • negative in juvenile paretic neurosyphilis, [298].
  • negative in spinal fluid in spinal syphilis, [148].
  • negative in spinal fluid in neurosyphilis, [101].
  • negative in neurosyphilis, [252].
  • negative in paretic neurosyphilis, [77].
  • technique, [476].
  • titrations in spinal fluid, [348].
• Wassermann, Neisser and Bruck, [428].
• Weiler, [214].
• Weygandt, [403], [404].
• Widal, Sicard, Ravaut, [428].
• Wiles and Stokes, [186].
• Word-deafness, [35], [43].
• X-ray diagnosis of bone conditions, [136].
• Yerkes-Bridges, [304].
• Ziehen, [409].
• Zsigmondi, [429], [474].

---

[1]. The cases chosen to illustrate the propositions of the boxed headings always illustrate several other points. See the footnotes of Section VI for lists of cases illustrating special points. The names assigned to the cases are fictitious and chosen to suggest race or descent.

[2]. Notes of Dr. James J. Putnam.

[3].

• M = meningeal
• V = vascular
• P = parenchymatous

[4]. E. E. Southard: Lesions of the granule layer of the human cerebellum; Journal of Medical Research, XVI, 1907.

[5]. Proof of marked parenchymatous lesions must hang on post mortem data; the inference here as to the presence of parenchymatous lesions is a clinical inference.

[6]. Reprinted from an article by Southard & Solomon: “Latent neurosyphilis and the question of Paresis sine paresi.” Boston Medical & Surgical Journal, XXIV, 1.

[7]. Solomon: “How Shall Latent Syphilis be Treated? The Prophylaxis of Syphilis of the Central Nervous System.” Interstate Medical Journal, XXIII, 8.

[8]. Joseph Collins: Syphilis of the Brain, Journal American Medical Association, July 10, 1915, Vol. LXV, pp. 139–144.

[9]. A. M. Barrett has recently discussed this subject in a paper in the Journal of the American Medical Association, Vol. LXVII, Dec. 2, 1916.

[10]. Reprinted from an article by Southard & Solomon: “Latent neurosyphilis and the Question of Paresis sine paresi.” Boston Medical and Surgical Journal, XXIV, 1.

[11]. E. E. Southard. A case of glioma of the pineal region, Am. Jour. of Ins., Vol. LXI, 1905.

[12]. Since this was written Collins has had further difficulties related to his neurosyphilis, improving under treatment.

[13]. Warthin: “Persistence of active lesions and spirochetes in the tissues of clinically inactive or ‘cured’ syphilitics,” American Journal of Medical Sciences, CLII, 1916.

[14]. “The Significance of Changes in Cellular Content of Cerebrospinal Fluid in Neurosyphilis,” Boston Medical and Surgical Journal, CLXXIII, 27.

[15]. Plaut: Ueber Halluzinosen der Syphilitiker, Berlin, 1913.

[16]. Borden S. Veeder: Hereditary Syphilis in the Light of Recent Clinical Studies; Am. Jour. of Med. Sc., CLII, 1916.

[17]. Reprinted from article by Southard and Solomon: “Latent Neurosyphilis, the Question of Paresis sine paresi,” Boston Medical and Surgical Journal, XXIV, 1.

[18]. (This case was furnished by Dr. D. A. Haller from the Peter Bent Brigham Hospital series.)

[19]. Fernald, W. E. Standardized Fields of Inquiry for Clinical Studies of Borderline Defectives. Mental Hygiene, Vol. 1, No. 2, April, 1917.

[20]. Goddard, H. H., Feeblemindedness, its Causes and Consequences, 1914.

[21]. W. E. Fernald and E. E. Southard. Waverley Research Series in the Pathology of the Feebleminded. Proceedings of the American Academy of Arts and Sciences, 1917.

[22]. Thibierge. La Syphilis dans l’armée, 1917.

[23]. Hecht. Wien. klin. Woch., xxix, 51.

[24]. Donath. Beiträge zu den Kriegsverletzungen und -er-krankungen des Nervensystems. Wiener klin. Wehnschr., No. 27–8, 1915.

[25]. Duco et Blum. Guide pratique du Médecin dans les Expertises médicolégales militaires. Paris, 1917.

[26]. Birnbaum. Kriegsneurosen und -psychosen auf Grund der gegenwärtigen Kriegsbeobachtungen: Sammelbericht. Z. f. d. ges. Neurol. u. Psychiat., Bd. XII, H. 1, 1915.

[27]. Weygandt. Kriegseinflüsse und Psychiatrie. Jahreskurse f. ärztl. Fortbildung, Maiheft, 1915.

[28]. Bonhoeffer. Erfahrungen über Epilepsie und Verwandtes im Feldzuge. Monatschr. f. Psychiat u. Neurol., Bd. 38, H. 1–2, 1915.

[29]. Exner, M. J., Prostitution in its relation to the army on the Mexican Border, Social Hygiene, Vol. 3, 2, April, 1917.

[30]. Bonhoeffer, loc. cit.

[31]. We have recently reviewed the outcome in 300 untreated cases of paretic neurosyphilis (Psychopathic Hospital material, strictly comparable with treated cases) finding but 5 now capable of self-support and 10 more in normal-looking remission. This percentage is far lower than that in treated cases (at present, July, 1917, 50 in 200 capable of self-support).

[32].

• Alice Morton (1).

[33].

• Francis Garfield (2).

[34].

• John Dixon (3).

[35].

• James Pierce (4).

[36].

• John Lawrence (5).

[37].

• Flora Black (6).

[38].

• Mrs. Lecompte (7).

[39].

• John Wyman (8).

[40].

• Greeley Harrison (9). Also
• Albert Robinson (45),
• Alice Caperson (46),
• Abel Bachmann (74).

[41].

• Lyman Agnew (10). Also
• Ethel Hunter (47),
• Bessie Vogel (52),
• Isaac Thompson (83),
• Juliette Lachine (11).

[42].

• Juliette Lachine (11). Also
• Lyman Agnew (10),
• Ethel Hunter (47),
• Bessie Vogel (52),
• Isaac Thompson (83).

[43].

• Henry Philipps (12). Also
• Bridget Curley (59),
• Margaret O’Brien (68),
• Annie Martin (117).

[44].

• William Twist (13). Also
• Lester Crane (20),
• Thomas Donovan (23).

[45].

• John Jackson (14). Also
• Martha Bartlett (21),
• Paolo Marini (28),
• Margaret O’Brien (68).

[46].

• Pietro Martiro (15). Also
• Meyer Levenson (22),
• Achilles Akropovlos (50).

[47].

• Joseph Sullivan (16).

[48].

• Gregorian Petrofski (17). Also
• Richard Lawlor (25),
• John Bennett (34),
• Julius Kantor (54),
• Albert Forest (112).

[49].

• Frederick Wescott (18). Also
• Martha Bartlett (21),
• James Burns (56),
• Victor Friedburg (108).

[50].

• Agnes O’Neil (19). Also
• Michael O’Donnell (24).
• John Edwards (104).
• Arthur Bright (121).

[51].

• Lester Crane (20). Also
• Greeley Harrison (9).
• David Borofski (49).
• David Collins (61).

[52].

• Martha Bartlett (21). Also
• Agnes O’Neil (19),
• Vivian Walker (87).

[53].

• Meyer Levenson (22). Also
• Albert Forest (112).

[54].

• Thomas Donovan (23). Also
• William Twist (13),
• Bessie Vogel (52),
• David Collins (61).

[55].

• Michael O’Donnell (24). Also
• Alice Morton (1).

[56].

• Richard Lawlor (25). Also
• Bessie Vogel (52),
• —— —— (88).

[57].

• John Morrill (26).

[58].

• David Tannenbaum (27).
• Also Mrs. LeCompte (7),
• Annie Rivers (109).

[59].

• Paolo Marini (28). Also
• Flora Black (6).

[60].

• Mario Sanzi (29). Also
• Stephen Green (30),
• Paul Halleck (31).

[61].

• Stephen Green (30). Also
• Paul Halleck (31),
• Henri Lepère (105),
• Ivan Rokicki (111).

[62].

• Paul Halleck (31).

[63].

• Margaret Neal (32).

[64].

• Joseph Graham (33).

[65].

• John Bennett (34). Also
• Alice Caperson (46),
• Florence Fitzgerald (81),
• Vivian Walker (87),
• Arthur Bright (121).

[66].

• Mary Coughlin (35).

[67].

• Theresa Mullen (36). Also
• John Lawrence (5),
• John Friedreich (77),
• Gridley Ringer (78),
• James Arnold (80).

[68].

• Isaac Goldstein (37).

[69].

• Archibald Sherry (38).

[70].

• Caroline Davis (39).
• H. F. (40).
• Samuel North (41).
• Elizabeth Brown (42).
• Robert Allen (43).
• John Hughes (44).

[71].

• Albert Robinson (45). Also
• Greeley Harrison (9).

[72].

• Alice Caperson (46). Also
• Florence Fitzgerald (81).

[73].

• Ethel Hunter (47). Also
• Lyman Agnew (10),
• Bessie Vogel (52),
• Juliette Lachine (11).

[74].

• Milton Safsky (48). Also
• Daniel Falvey (55).

[75].

• David Borofski (49). Also
• Lester Crane (20).

[76].

• Achilles Akropovlos (50).

[77].

• Daniel Wheelwright (51).

[78].

• Bessie Vogel (52). Also
• Lyman Agnew (10),
• Juliette Lachine (11),
• Ethel Hunter (47).

[79].

• Carrie Pearson (53).

[80].

• Julius Kantor (54). Cf.
• James Burns (56).
• Henri Lepère (105).
• Frederick Stone (106).

[81].

• Daniel Falvey (55). Cf.
• Francis Murphy (60).

[82].

• James Burns (56). Also
• Frederick Wescott (18),
• Martha Bartlett (21),
• Victor Friedburg (108).

[83].

• John Summers (57).

[84].

• Peter Burkhardt (58).

[85].

• Bridget Curley (59).

[86].

• Francis Murphy (60).

[87].

• David Collins (61).

[88].

• Joseph Buck (62).

[89].

• Albert Fielding (63).

[90].

• Calvin Hall (64).

[91].

• Donald Barrie (65).

[92].

• Lawrence Washington (66).

[93].

• Joseph Temple (67).

[94].

• Margaret O’Brien (68). Also
• Henry Phillips (12).
• Bridget Curley (59).
• Annie Martin (117).

[95].

• Frank Mason (69).

[96].

• Annie Kelly (70).
• James Lauder (71).

[97].

• James Lauder (71).

[98].

• Margaret Green (72).

[99].

• Marcus Chatterton (73).

[100].

• Abel Bachmann (74).

[101].

• Mrs. Brown (75).

[102].

• James Seabrook (76).

[103].

• John Friedreich (77). Cf.
• Isaac Goldstein (37).

[104].

• Gridley Ringer (78).

[105].

• John Doran (79).

[106].

• James Arnold (80).

[107].

• Florence Fitzgerald (81). Also
• John Bennett (34),
• Alice Caperson (46),
• Vivian Walker (87),
• Arthur Bright (121).

[108].

• Frederick Estabrook (82).

[109].

• Maj. Isaac Thompson, M.D. (83).

[110].

• Lester Smith (84).

[111].

• Annie Marks (85).

[112].

• Frank Johnson (86).

[113].

• Vivian Walker (87).

[114].

• —— —— (88). Cf.
• Richard Lawlor (25).
• Bessie Vogel (52).

[115].

• Margaret Tennyson (89).
• John Lawrence (5).
• Mary Coughlin (35).
• Theresa Mullen (36).
• John Friedreich (77).
• Gridley Ringer (78).
• James Arnold (80).

[116].

• Joseph O’Hearn (90).

[117].

• Levi Sussman (91).

[118].

• Joseph Larkin (92).

[119].

• Richard Marshall (93).

[120].

• David Fitzpatrick (94).

[121].

• Joseph Wilson (95).

[122].

• Becky Bornstein (96).
• Walter Heinmas (97).
• Mr. Jacobs (98).

[123].

• Walter Heinmas (97).

[124].

• Mr. Jacobs (98).

[125].

• James McDevitt (99).

[126].

• Jacob Methuen (100).

[127].

• John Baxter (101).

[128].

• Theodosia Jewett (102).

[129].

• A. W. (103).

[130].

• John Edwards (104). Cf.
• Henri Lepère (105),
• Frederick Stone (106),
• Arthur Bright (121),
• Agnes O’Neil (19),
• Paolo Marini (28).

[131].

• Henri Lepère (105). Cf.
• Julius Kantor (54).

[132].

• Frederick Stone (106).

[133].

• Greta Meyer (107). Cf.
• John Jackson (14).

[134].

• Victor Friedburg (108).

[135].

• Annie Rivers (109).

[136].

• Mr. McKenzie (110). Cf.
• Ivan Rokicki (111).

[137].

• Ivan Rokicki (111).

[138].

• Albert Forest (112). Cf.
• Gussie Silverman (113),
• Walter Henry (114),
• William Rosetti (116),
• Annie Martin (117),
• Levi Morovitz (122),
• Peter Burkhardt (58).

[139].

• Gussie Silverman (113).

[140].

• Walter Henry (114).

[141].

• Henry Ryan (115).

[142].

• William Rosetti (116).

[143].

• Annie Martin (117). Cf.
• William Roberts (118).

[144].

• William Roberts (118).
• John Silver (119).

[145].

• John Silver (119).

[146].

• James McGinnis (120).

[147].

• Arthur Bright (121). Cf.
• Levi Morovitz (122),
• John Bennett (34).

[148].

• Levi Morovitz (122).

[149].

• Robert Matthews (23). Cf.
• Isaac Goldstein (37).

[150]. For cases in which, without autopsy we have risked the diagnosis neurosyphilis in the absence of W. R. in serum or fluid, see William Twist (13), Frederick Wescott (18), Martha Bartlett (21), Thomas Donovan (23), Paolo Marini (28), Margaret Neal (32), Bridget Curley (59), Victor Friedburg (108), Ivan Rokicki (111).

[151]. From Mallory and Wright: Manual of Laboratory Technique.

[152]. Bruck. Münch. med. Wochen. Jan. 22, 1917.

[153]. Smith and Solomon. Boston Medical and Surgical Jour.

[154]. Bruck: Journal of American Medical Association, Vol. lviii, No. 12, March 24, 1917, p. 944.

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TRANSCRIBER’S NOTES

1. Pg. [456], added footnote anchor for footnote A.
2. Silently corrected typographical errors and variations in spelling.
3. Archaic, non-standard, and uncertain spellings retained as printed.
4. Footnotes were re-indexed using numbers and collected together at the end of the last chapter.