FOOTNOTES:

[134] See Karell Cure, p. [342].

[135] “Food for the Sick,” p. 150, by Strouse and Perry.

[136] See Salt-poor Diets, p. [341].


CHAPTER XX
DIABETES MELLITUS

Definition.—Diabetes is a disease which is characterized by an inability on the part of the body to utilize the carbohydrates, in consequence of which there is abnormal excretion of glucose in the urine.

Sugar in the Urine.—The appearance of sugar in the urine may not necessarily signify diabetes, it may be merely a temporary glycosuria due to certain pathological conditions, such as infectious diseases, diseases or trauma which affect the pancreas, and which disappear upon the recovery from the disease. But any appearance of sugar in the urine should be looked upon with suspicion, since the future welfare of the patient depends largely upon an early diagnosis in any form of diabetes.

True Diabetes.—Allen claims that true diabetes may always be distinguished from nervous glycosuria by the application of the laws governing these conditions (Allen’s Paradoxical Law[137]), which is “whereas in normal individuals the more sugar given the more is utilized, the reverse is true in diabetes.”

Manufacture of Sugar from Other Foods.—If the carbohydrate foods alone caused all the trouble in diabetes, the disease might be more easily controlled. This, we found, however, not to be true, since in certain conditions the body utilizes the protein foods for the manufacture of glucose also. Consequently in diabetes if the absolute sugar output of the body is to be controlled, the intake of nitrogenous foods must be likewise adjusted.

Functions of Carbohydrates.—In the chapter describing the functions of the carbohydrates in the human body it was demonstrated that their energy-producing properties did not cover the extent of their usefulness. It has been proved that this food constituent normally acts as neutralizing agent for the toxic acids produced within the organism as a result of the breaking down of the fats. Hence, when this function of the carbohydrates becomes impaired, these acids, Oxybutyric acid, Diacetic acid and Acetone, fail to be neutralized and are consequently absorbed into the blood stream, giving rise to a form of intoxication known as acidosis. When acidosis becomes extreme, the diabetic patient is apt at any time to succumb to the dreaded diabetic coma.

Keeping Urine Sugar Free.—Thus it is seen that the treatment of diabetes mellitus consists not alone of freeing the urine from sugar and keeping it free, but of controlling the acidosis which may at any time develop.

Diabetic Cures.—Numberless so-called diabetic cures have been brought forward and more or less tested for years, but whether they have really accomplished cures has not been satisfactorily proved. Not until Dr. Allen instituted what is known as the Allen’s Starvation Treatment has the disease been so universally treated, at least by one method or modification of one method. Dr. Joslin, who has used this treatment most successfully, does not claim to have accomplished a cure, but states that he is watching the results of the treatment in his patients with interest.

Starvation Treatment.—The Allen Starvation Treatment consists of first a period of about forty-eight hours in which the patient is given an ordinary diet, during which time the daily weight is taken and the urine examined and recorded.

Acidosis.—It has been found in some cases, such as with elderly patients or those in whom there is an evident acidosis, advisable to precede the period of starvation by a preliminary treatment.

Method of Treatment.—Joslin[138] suggests the following method of procedure:

“Without otherwise changing the diet omit fat. After two days, omit protein, then halve the carbohydrates daily until the patient is taking only ten grams, then fast.”

In the Michael Reese Hospital, the following series of test diets are given to determine the severity of the diabetes:

Diabetic Test Diets[139]

BREAKFAST
Grapefruit ½
Eggs 2
Bacon 20 grams
Bread 25 grams
Butter 10 grams
Cream 15 c.c.
Coffee 1 cup
DINNER
Cream soup 3 oz.
Roast beef 75 grams
Spinach100 grams
Kohl-rabi100 grams
Lettuce salad 50 grams
Ripe olives 15 grams
Bread 25 grams
Butter 20 grams
Wine gelatin 4 oz.
Coffee
Cream 15 c.c.
SUPPER
Lamb chop 1
Asparagus tips 50 grams
Eggplant 50 grams
Tomato salad 50 grams
Custard (diabetic)
Coffee
Cream 15 c.c.
Butter 20 grams
Bread 25 grams

Diet in Mild Cases.—This diet contains approximately 70 grams of protein, 100 grams of fat, and 70 grams of carbohydrates, and the patient is kept on it for at least two days; then the carbohydrates are cut down by taking away 25 grams of bread every day.

Diabetic Diets[140]

Key:
ACarbohydrate
BProtein
CFat
DCalories
E5% Vegetable
FOrange
GOatmeal
HShredded Wheat
IUneeda
JPotato
KBread
LEgg
MCream 20% fat
NBacon
OButter
PMeat
QFish
RSkimmed Milk
Diets with which to become Sugar freeDiet in GramsTest DietsName of Diet
ABCDEFGHIJKLMNOPQR
T. D.118989151247300300...1...24090............901204801
T. D.2102580640300300...1...120..................1803002
T. D.364330388300300.........60..................902403
T. D.436270252300200..............................901204
T. D.515508030050....................................5
Maintenance Diets Carbohydrate (C)Protein and Fat (PF)
C1+PF110116138300..................1..................1
C2+PF2221318302300100...............160...............2
C3+PF3322424440600100...............260...............3
C4+PF4422939635600200...............26030............4
C5+PF552325381360020015............2603015.........5
C6+PF6634365100960020030............290301530......6
C7+PF7735170112660030030............290301560......7
C8+PF8835987135160030030...2......290303090......8
C9+PF9966293146960030030½2......2120303090......9
C10+PF10107639315176003003012......2120303090......10
C11+PF11131759817066003003012120...21203030120......11
C12+PF12155799818186003003012240...21203030120......12
FoodWeight in gramsApproximate equivalent
Orange300One and one-half (large size)
5 per cent vegetables300Three moderate portions
Skimmed milk480One pint (16 ounces)
Fish120Two small portions
Potato240Two medium sized potatoes
Meat90One moderate portion
Bread90Three small slices
Oatmeal (dry wgt.)30One large saucerful
Cream60Four tablespoonfuls
Bacon30Four crisp strips
Butter30Three medium portions

The Test Diets are designed for the period during which the patient becomes gradually sugar free. On successive days advances can be made from Test Diet 1 to Test Diet 5, and if on the fifth day the patient is not sugar free, fasting can be employed for one or more days.

The Maintenance Diets are for use so soon as the urine of the patient is free from sugar. If this occurs as a result of Test Diet 5 the patient begins with Maintenance Diet C1PF1. The actual articles of food representing the carbohydrate in the diet for the first day are given under the heading of carbohydrate, for convenience described C1, 2, 3, etc. The articles referred to under protein and fat are under that heading, which for the same reason is described as PF1, 2, 3, etc. Certain cases of diabetes can proceed steadily day by day from C1PF1 to C12PF12, without showing sugar. If sugar does appear in the urine, drop back two days in the carbohydrate group, wait till sugar free, then advance in the protein and fat group until sufficient calories are obtained. Thus, if sugar shows on C7PF7 the diet prescribed would be that included in C5PF7 and thereafter progression could be made in the PF group until twenty-five to thirty calories per kilogram body weight were furnished the patient.

Occasionally the patient becomes sugar free on Test Diet 2, 3, or 4. It is then unnecessary to begin with Maintenance Diet C1PF1, but instead with a maintenance diet which contains a value for carbohydrate similar to that of the test diet upon which the patient became sugar free.

If the protein and fat are too high for the individual on a given day it is easy to advance the carbohydrate and decrease to an earlier day on protein and fat.

The plan is arbitrary and the majority of cases will demand some modification. It is arranged to enable patient or nurse to see in advance the general plan of treatment.

(Courtesy of Dr. Joslin and Thomas Groom & Co., Boston.)

If the case is a mild one, this may be sufficient to free the urine from sugar, but the diet is given primarily to enable the physician to find out by means of urinalysis just how great is the functional impairment.

In some cases, which are mild in character, the urine is made free of both sugar and acetone without further dietetic measures. However, when a severe diabetes is manifested and a high percentage of glucose and in some cases acetone bodies are found in the urine a more rigid treatment will be found necessary.

Preliminary Diet.—Many physicians find it advisable, as has already been stated, to cut down the food allowance before stopping it entirely. In the Michael Reese Hospital this is done by first giving a practically fat-free diet, followed by one or two days in which three or four eggs, 250 to 300 grams (8 or 10 ounces) of 5% vegetables are given, after which it is found safe to institute the starvation treatment.

Sample Menus.—The following menus are given to illustrate the dietetic treatment which it is deemed advisable to institute in cases where the starvation treatment cannot be given at once:

After the test diet of forty-eight hours, the following régime is instituted:

Third Day

Key:
AProtein Gm.
BFat Gm.
CCarbohydrate Gm.
DCalories
ABCD
Breakfast:
½ grapefruit 5.0020
1 egg5.34.10 59
1 slice bread30 gm.2.6.3015.0073
Tea or coffee
Total for meal 7.94.4020.00152
Dinner:
Broth180 c.c.3.7.17.3418
Chicken (breast)90 gm.18.22.10 92
Spinach100 gm.2.0 3.0020
Potato (1 medium)90 gm.1.8.0915.6070
Lemon jelly90 gm.4.2 2.7027
Total for meal29.92.3021.60227
Supper:
Lamb chop50 gm.9.314.10 126
Asparagus100 gm.1.5 3.0018
Bread20 gm.1.6.2010.0048
Tea or coffee
Total for meal12.414.3013.00192
Total for day40.221.0054.60571

Fourth Day

Key:
AProtein Gm.
BFat Gm.
CCarbohydrate Gm.
DCalories
ABCD
Breakfast:
½ grapefruit 5.020
1 egg5.34.10 59
1 slice bread20 gm.1.6.2010.048
Coffee or tea
Total for meal6.94.3015.0107
Dinner:
Tomato bouillon180 gm.2.2.232.515
Whitefish90 gm.2.0 5.028
Boiled onions100 gm.1.5.307.540
Bran muffin (1)5.07.004.5101
Tea or coffee
Total for meal25.716.2020.5322
Supper:
1 egg5.24.10 59
Tomato (baked)100 gm..6 2.010
Bran muffin (1)1.05.007.0101
Tea or coffee
Total for meal6.89.109.0170
Total for day38.429.6044.0513

Fifth Day

Key:
AProtein Gm.
BFat Gm.
CCarbohydrate Gm.
DCalories
ABCD
Breakfast:
½ grapefruit 5.020
Broiled tomato100 gm.1.50 3.018
Tea or coffee
Total for meal1.50 8.038
Dinner:
Broth120 c.c.3.00 12
Lettuce50 gm..50 1.58
Cauliflower90 gm.1.50.403.925
Tea or coffee
Total for meal5.00.405.445
Supper:
1 egg5.354.16 59
String beans100 gm.2.00 5.028
Celery50 gm..50 1.58
Tea or coffee
Total for meal7.854.166.585
Total for day14.3012.5019.9168

Sixth Day

Key:
AProtein Gm.
BFat Gm.
CCarbohydrate Gm.
DCalories
ABCD
Breakfast:
Asparagus tips60 gm.1.50 3.018
Spinach60 gm.1.101.801.832
Tea or coffee
Total for meal2.681.805.850
Dinner:
Stewed celery100 gm.1.00.102.115
String beans50 gm.1.50 2.516
Tea or coffee
Total for meal2.50.105.631
Supper:
Beet tops75 gm.1.50 2.516
Onions (boiled)75 gm.1.50.307.544
Tea or coffee
Total for meal3.00.3010.060
Total for day11.202.2021.4141