SPIRITUS AETHERIS NITROSI—SPIRIT OF NITROUS ETHER—SWEET SPIRITS OF NITER
An alcoholic solution of ethyl nitrate, yielding when freshly prepared not less than four per cent of ethyl nitrate.
Derivative.—Mix sulphuric acid (40 c. c.) with water (120 c. c.), cool and add alcohol and water each, (85 c. c.) and place in (1000 c. c.) flask surrounded by ice and water. Dissolve sodium nitrate (100 gm.) in water (285 c. c.), filter and allow filtrate to drop slowly into the flask above. Wash ethyl nitrate formed with sodium carbonate solution, to remove acid, and agitate with potassium carbonate, to remove water. Add ethyl-nitrate to 22 times its weight of alcohol.
Properties.—A clear, mobile, volatile, inflammable liquid, of a pale-yellowish or faintly greenish-yellow tint, having a fragrant ethereal and pungent odor, free from acidity, and a sharp burning taste. Mixes freely with water and alcohol.
Doses as a Stimulant and Antispasmodic.—Horses, 1 to 3 oz.; cattle, 1 to 4 ozs.; sheep, 2 to 4 dr.; pigs, 1 to 2 dr.; dogs, 15 m. to 1 dr. As a febrifuge and diuretic horses take from 4 dr. to 1 oz.; 4 dr. is sufficient as a rule every two, three or four hours, usually combined with other medicines for all of its purposes, in fever and colic cases.
Actions.—Spirit of nitrous ether conjoins the action of the alcohol and ethyl nitrite of which it consists. It is hence a general stimulant and a relaxer and paralyzer of non-striped muscle. It relieves acute fever and the difficult breathing of bronchitis and asthma. It is antispasmodic, diaphoretic and diuretic. Large doses are narcotic.
Uses.—Consisting of strong spirit and a saline ether, when swallowed it stimulates the stomach and intestines; is hence stomachic, carminative and antispasmodic, and is prescribed to animals in indigestion, tympanites, colic and convalescence from debilitating disorders. But its properties as a diffusible nitrite, relaxing spasm of involuntary muscles, also come into operation. It dilates arterioles, thus decreases arterial tension, and hence is of special value in the acute stages of fever, whether depending upon specific conditions or local inflammation. It relaxes the muscular fibers of the bronchial tubes, and thus relieves the spasmodic contraction and difficulty of breathing, which characterise catarrh, bronchitis and some forms of asthma. It is specially indicated when the heart action is weak and there is difficulty of breathing—conditions frequently concurring in influenza of horses. During excretion, notably by the skin and kidneys, its twofold constitution is further useful as the alcohol stimulates secretion, while the ethyl nitrate dilates the lumen of contracted vessels, and thus diaphoresis and diuresis are promoted in fevers, local inflammations, rheumatism and other disorders. As it is readily decomposed, even by water, it should be diluted or mixed with other medicines or water only immediately before it is administered. It is usually given in cold water, beer or linseed tea.