CHAPTER III.
THE REASONABLENESS OF THE APPLICATION OF THE FACTS TO THE INFERENCE.
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SECTION I.
THE CHEMICAL THEORY OF EPIDEMICS UNTENABLE.
It has been inferred that the germs of disease possess the property of vitality, and a number of facts have been adduced to support the proposition that vitality is the indwelling force by which the matter generating epidemic and endemic disease exercises its influence over man and animals. The reasonableness of the application of these facts to the end in view has now to be considered. Chemistry cannot account for epidemics.
Our first subject of reflection points to the chemical discoveries of the last few years, and particularly to those of the great German chemist Liebig. We find in the first paragraph of his Organic Chemistry applied to Physiology and Pathology, the following words: "In the animal ovum, as well as in the seed of the plant, we recognize a certain remarkable force, the source of growth or increase in the mass, and of reproduction or of supply of the matter consumed; a force in a state of rest. By the action of external influences, by impregnation, by the presence of air and moisture, the condition
of static equilibrium is disturbed. This force is called the vital force, vis vitæ, or vitality."
The doctrine of Liebig, that the vital force manifests itself in two conditions, or rather, that it is known to be in two different states, that of static equilibrium as in the seed, and in a dynamic state, as in that of growth and reproduction, is perfectly applicable to the germs of disease; the static equilibrium is referrible to the matter of vaccine lymph when dried and preserved for use, and the dynamic forces of the matter are known to be in operation during its reproduction and growth in the system of the vaccinated child.
Then as to reproduction of matter by any chemical process, our author can furnish us with no examples, for even in his explanation of the causes of disease he is quite silent on this point, merely acknowledging that diseased products must be either rendered "harmless, destroyed, or expelled from the body." He further says, that "in all diseases where the formation of contagious matter and of exanthemata is accompanied by fever, two diseased conditions simultaneously exist, and two processes are simultaneously completed," and that it is by means of the blood as a carrier of oxygen that neutralization or equilibrium is established. Liebig thus admits that an agent exists in the blood, capable of deteriorating it at the expense of the oxygen, which he maintains is contained in the red globules; he further acknowledges that two processes of diseased
action are going on at the same time, and though he does not explain them, I imagine him to mean that new contagious matter is generated and eliminated from the blood, and that at the same time, there is that condition of body which he would call simply a diseased state, and characterizes it thus: "Disease occurs when the sum of vital force which tends to neutralize all causes of disturbance, (in other words, when the resistance offered by the vital force) is weaker than the acting cause of the disturbance."
If I rightly apprehend his notions, they perfectly harmonize with my ideas, to a certain extent, on the subject. They accord, at any rate, most completely with the theory attempted to be established, and fully confirm the reasonableness of the application of the facts recorded to the inference drawn from other sources. The difference only rests on the question whether vitalized or non-vitalized matter is the fons et origo mali.
How is the production of new matter, resembling that originally causing the disease, to be explained by any known hypothesis, except on the assumption of living organized matter? Though Liebig and Mulder both deny the fact, that the Torula cerevisiæ is the sole agent in the process of fermentation: they both equally fail in shewing upon what it does depend, and their difficulty rests entirely on their incapacity to explain the uniform reproductive properties of the matter engaged in this, as well as in all other allied operations. Liebig's statement
however on this matter requires notice—he says, "that putrifying blood, white of egg, flesh and cheese, produce the same effects in a solution of sugar, as yeast or ferment. The explanation is simply this; that ferment or yeast is nothing but vegetable fibrine, albumen or caseine, in a state of decomposition."
This state of decomposition, however, involves a much more complex proceeding, than simply a reduction of matter into its elementary forms of gases, earths, and minerals; for we nowhere find decomposition of this kind going on without the development of some organized bodies, either animal or vegetable: and since we have seen that the spores of the cryptogami are always in existence in the atmosphere, and making their appearance under favouring conditions, and especially when we find that fermentation is invariably accompanied, and I may safely say, preceded by the deposition in the fluid of the sporules of the Torula, we can hardly believe that they are any other than the sole agents of the process. I have now a considerable quantity of the Torula obtained from the urine of a diabetic patient, in which they appeared, as it were, spontaneously. After the urine had been allowed access to the air for a certain time, and the whole of the saccharine matter was converted into new compounds, reproduction of the Torula ceased;—and those which remained when the process was completed, still continue as organic cells, deposited
in the bottle in an inert state, but ready, on the addition of fresh sugar, as has been proved, to resume an active existence. These germs, it is now well known, may be dried into powder, so as to be blown away like dust without any, or but little, detriment to their vital energies; and there is now no doubt that they exist in this condition in the air, as do the spores of mucor, aspergillus, oidium, agaricus, and all other fungi.
Mulder, however, does allow some properties to the yeast vesicle; he says, "a variety of strange ideas have been entertained respecting the nature of yeast; recent experiments have convinced me that it undoubtedly is a cellular plant consisting of isolated cells. They resemble the composition of cellulose in some respects, but differ from it in many." "These vesicles, consisting of a substance resembling that of cells, do not contribute in the least to the fermentation, but are exosmotically penetrated during fermentation by the protein compound." These chemists seem to have an instinctive horror of allowing any active properties to the yeast vesicle, that is as far as the conversion of sugar into carbonic acid and alcohol is concerned in the act of fermentation. Dr. Carpenter, as if desiring to conciliate the chemical and physiological disputants, considers that the truth is to be found in the mean of the two extremes,—that is, that the process of fermentation is neither entirely dependent on chemical laws, nor on those laws which preside
over the growth of reproductive matter, but is a process in which both perform certain offices, each depending on the other to produce the combined result; he thus approaches more nearly to the theory of Mulder, than that of Liebig.
But to revert to Mulder, he speaks of the Torula cells being "exosmotically penetrated during the process of fermentation by the protein compound." Now the Torula is acknowledged to be one of the Fungals, and the chemical constituents of the Fungi approach very nearly that of animal tissues. They contain a peculiar principle, residing in and obtainable from them, termed Fungin, which is as highly azotised as animal fibre. The protein compound alluded to, Mulder says, is not gluten, because insoluble in boiling alcohol, and not albumen, because it is very readily dissolved in acetic acid, and he regards it as a superoxide of protein. This superoxide of protein can only have been produced by a vital action in the cells of the Torula, and as the fungi consume oxygen, and give out carbonic acid, we clearly have all the elementary conditions for their growth in almost all decomposing animal and vegetable matters. It is the nature of the fungi to live on organized matter, but always when it has a tendency to decay; it is for this reason they have been called "Scavengers." Again, we can understand why some animalized or nitrogenous matter should be necessary for fermentation, otherwise fungi could not grow, nitrogen being an essential constituent of
their structure, and further fermentation does not commence without the presence of oxygen, and like as in animals, this gas supports their existence. The conversion of sugar into alcohol is represented by the following formula:—
| Result. | |||
| Sugar. | Alcohol. | Carbonic Acid. | |
| Hydrogen | 3 | 3 | |
| Oxygen | 3 | 1 | 2 |
| Carbon | 3 | 2 | 1 |
If therefore the process were merely of a chemical nature, where is the necessity for atmospheric oxygen to accomplish the end? it is quite certain that fermentation cannot go on without its presence. Let us compare the action of ferment or yeast in a dried state to the action of albumen, which Liebig says is sufficient when decomposing to set up fermentation. "The white of eggs when added to saccharine liquors requires a period of three weeks, with a temperature of 96° F. before it will excite fermentation."[[42]] But any saccharine liquor on exposure to the air, though entirely destitute of albumen or gluten, will ferment, and the Torula may be found in it. I have found the Torula in a great variety of syrups which have spontaneously undergone fermentation. I have also discovered that the development of the cells is delayed or accelerated by the nature of the ingredient used in flavouring
the syrups, with other peculiarities which need not here be mentioned.
But the conversion of starch into sugar by means of gluten requires some notice, as by some persons it is associated in their minds with the organic process of fermentation.[[43]] Mulder ascribes the latter in the first instance to the action of heat, evidently believing that the pseudo-catalytic operation of gluten upon starch is the type of all such actions, and regarding them all as simply chemical, but we here distinguish a wide difference; in the latter instance the gluten is decomposed, and rendered unfit for a repetition of the chemical phenomenon, and if it is desired to renew the action fresh gluten must be obtained, and a certain temperature kept up, otherwise the experiment fails. How different is fermentation: in the ordinary temperature of the atmosphere the yeast vesicle will multiply, no incremental or unnatural addition of heat is requisite, and it is one of the commonest and most natural instances of vegeto-chemistry: the grape cannot shed its juice, nor the sugar cane its sap without admitting these germs, which, under certain
conditions multiply themselves and convert the saccharine elements into new compounds. The method by which the conversion of starch into sugar is accomplished is thus described by Dr. Ure. He says that if starch one part be boiled with twelve parts of water and left to itself, water merely being stirred in it as it evaporates, at the end of a month or two in summer weather it is changed into sugar and gum, bearing certain proportions to the amount of starch used. But "if we boil two parts of potato starch into a paste, with twenty parts of water, mix this paste with one part of the gluten of wheat flour, and set the mixture for eight hours in a temperature of from 122° to 167° F. the mixture soon loses its pasty character, and becomes by degrees limpid, transparent, and sweet, passing at the same time first into gum and then into sugar."—"The residue has lost the faculty of acting upon fresh portions of starch."
Four points of contrast present themselves for notice as elements of comparison with true fermentation. 1st. The starch solution has to be boiled, so that heat, by which it is to be supposed that the starch globule is ruptured, seems to be an essential portion of the chemical change, and even this may in fact alone be sufficient in such a case to produce some elementary change in the starch, and may prepare it for the subsequent catalytic action of some related organic, though not vital material.[[44]]
2nd. Not only a summer heat is necessary, but a period of one or two months time must elapse before the starch with the water simply becomes converted into sugar, and if artificial heat is to be used to hasten the operation, a temperature from 122° to 167° F. must be resorted to in order to obtain the desired result. 3rd. When even this is accomplished there is no reproduction of the fermenting matter, and artificial and chemical means must again be applied to repeat the experiment. 4th. The conversion of starch into sugar can be accomplished without the presence of gluten at all, by the aid only of temperature and time. It seems to me, therefore, to be entirely unnecessary to occupy more space in the elaboration of a proof of the doctrine that the germs of the Torula are the sole agents in the conversion of saccharine fluids into alcohol and carbonic acid. By another chemical process starch can be converted into sugar, but I am not aware that hitherto any method has been discovered by which sugar can be converted into alcohol except by the process of fermentation proper.
I have been thus particular in commenting on this subject, as it bears, in an especial manner, on the question under consideration.
The physiologist cannot afford to lose this process from the category of chemico-vital, or biochemical manifestations.[[45]] The philosophy of the age has a tendency to make every thing chemical; it is true that the Divinity is as much seen in the laws which govern the elementary particles of matter, as in those laws which preside over the transmutation and sustentation of those elementary and inorganic particles, when compounded in the tissues which are engaged in the formation of living beings. The laws by which acids and alkalies neutralize each other, and the affinities single, double and elective, which the particles of matter exhibit, together with the influences of light, heat, and electricity upon almost every condition of matter, are as truly wonderful as the creative power. Man may, in many instances, imitate the processes of nature, he can render iron magnetic, and form alkaloids, but the
laws which govern the particles of matter are still the secret of the whole proceedings. We do but interpret the language of nature in discovery, the book is ever open before us, and every atom of the world is a word and a theme, capable of occupying the short span of sublunary existence allotted to man. We have read of "sermons in stones," but a book has been written on a "pebble."[[46]]
To return, as we every where in nature find a gradual transition in the forms, arrangements and properties of matter, so we may expect to find a link between the inorganic and vital chemistry of nature. The fungi, by which we contend this transition appears to be accomplished, are also a link in chemical composition, between the animal and vegetable kingdom, and not only in that, but in their subsisting upon matter which has been organized, they are deoxidizers and reducers, as the vegetable kingdom in its highest function is a compounder. To their functions and offices in the great scheme of creation, we may fairly apply ourselves with a sure and certain result of the most interesting discovery. Is it no hint that wherever decaying organic matter is found, there do we find fungi? is it no hint that they are found in all parts of the world? that even in snow the germs of fungi will grow and multiply to such an extent, according to Capt. Ross, that the protococcus was seen
by him, clothing the sides of the mountains at Baffin's Bay, rising, according to his report, to the height of several hundred feet, and extending to the distance of eight miles?
Even stones contain in their interior, or interspaces of their structure, the germs of fungi. A species of Tufa is found in the vicinity of Naples of a porous texture, which, when moistened and shaded, produces vast mushrooms, four or five inches high, and eight or ten inches broad.[[47]] This author further says: "In the Maremma, where the volcanic tufa is the basis of the soil the surface is intermixed with the animal remains of departed empires, and the ordure of cattle, is covered with grasses of old pasturages, and is wet with heavy dews. Everything, therefore, conspires there to a fungiferous end."
They are found growing in and upon both vegetables and animals. Nees von Esenbeck imagined, that minute forms multiplied themselves in the atmosphere; and really, when we consider the amount of effluvia composed of the atoms cast off from the bodies of living or decaying organic matters, which are incessantly passing into the atmosphere, the conjecture is not an unreasonable one. The minuteness of those, which we know are always found growing on decomposing bodies, does not preclude the possibility, nay, further favours
the probability, that others infinitely more minute,[[48]] may be destined to remove the more subtle and vaporous particles which escape into the air.
We can, therefore, I think, conclude, that the lower tribes of vegetation, may consistently be regarded as capable of existing in almost any condition, and almost under any circumstances, they may be made to grow in plants by inoculation, as shewn by De Candolle, and Dr. Hassall. If the stem of wheat also is inoculated with vibriones, they will make their appearance in the grain.[[49]] If the seed contain them and have not lost its germinating properties, these worms will be found again in the grain. If the grain containing them be dried for years, and moistened again with water, these animalcules, according to Bauer and Steinbach, will present all the phenomena of life. This experiment I have witnessed, and can confirm the statement. These animalcules in the diseased grain, have under the microscope the appearance of an immense
number of eels crowded together in a small space, and presenting a movement more, perhaps, vermicular than any other, and it is continued for a considerable time. Now if these animalcules, or their ova, can be proved to pass with the sap to the seed, there can be no difficulty in comprehending how germs, considerably more minute and of a vegetable nature, should be found subject to the same peculiar mode of obtaining an entrance into animals and vegetables for sustenance. "It is usually imagined," says Dr. Carpenter, "that the germs liberated by one plant are taken up by the roots of others, and being carried along the current of the sap, are deposited and developed, where vegetation is most active."
The chemical theory of disease would be better sustained by a comparison of "the artificial formation of alkaloids," and the phenomena of transformation of blood into the tissues of animals, and their degeneration into effete matters, and of sap into the tissues of plants and their degenerations.
Professor Kopp of Strasburg, says, "In a chemical point of view, the alkaloids are remarkable for their composition, for their special properties, both physical and chemical, and for the interesting reactions to which many of them give rise, when exposed to the influence of different reagents. Considered medically, the organic bases are distinguished by their energetic properties. They
constitute at the same time, the most violent and sudden poisons, and the most valuable and heroic remedies."
Upon this very intricate and interesting part of chemical philosophy, it is rather dangerous to enter without a thorough and practical knowledge of the subject. This, however, falls to the lot of few men. We, who are engaged in the study of disease, and of the best methods of cure, are obliged to take the investigations of the analytical chemist, and examine them for ourselves in the intervals of leisure allowed us during the active exercise of our calling. Though with less advantages for the study of these transcendental relations of organic and inorganic matter, we are not, nevertheless, precluded from forming our opinions on their practical bearings to the phenomena and treatment of disease.
That there is a matter of a poisonous nature concerned in the production of endemic and epidemic affections, cannot be doubted by any one; I believe indeed, that the chemical theorists admit this, at all events Liebig does, for he says, "The morbid poison changes in the blood are fermentative, just such as occur in beer making." If we start, then, with the consideration that poisons, in a chemical point of view, are the objects of our research; the obvious course to take is to enquire what is the source of poisons generally, and what their effects on the animal economy? The mineral poisons are entirely excluded from the enquiry by their
inaptitude for diffusion, and their uniform effects upon all persons, differing only in degree in their operation. The same objections apply to gaseous poisons, except that to them the property of diffusion would be admitted.[[50]] We come then to the alkaloids, which constitute, as Kopp says, the most violent and sudden poisons. For the production of alkaloids by artificial means, organic products of some kind are required. Artificial heat, powerful chemical agents or length of time, are, as far as information at present extends, the indispensable requirements to induce these peculiar changes in matter. The only instance I can find, in which elementary matters can by artificial means be combined, so as to resemble the products of nature, is that of the conversion of carbon and nitrogen into cyanogen. But the process by which this is accomplished, leads rather to doubt whether it be really and simply by a combination of elementary carbon and nitrogen. I extract the following from the Annual Report of the Progress of Chemistry, for 1848. "H. Delbruck has performed some experiments on the important subject of the formation of cyanogen. He confirms the statements of Desfosses and Fownes, inasmuch as a weak but distinct formation of cyanogen was observed on igniting
sugar-charcoal[[51]] with carbonate of potassa in an atmosphere of nitrogen." The use of sugar-charcoal, may be perhaps an explanation of the weak formation of cyanogen, for in these numerous and successive chemical changes of matter, it is impossible to say how many sources of error may arise. The constant contradictions of each other, and the opposite statements made by chemists, of equal eminence, leave us in a wilderness of doubt, from which we are not likely to be freed, until definite laws shall be discovered to act as a guide in the comprehension of the higher branches of Chemical Philosophy.
But supposing that the generation of alkaloids could take place in the body, or some analogous poisonous matter, we have yet to imagine a whole host of peculiar and essential conditions to effect this change, besides an atmospheric agent or agents to set in motion those compositions and decompositions, capable of bringing out these new products from the elements of blood. We are aware that in the blood, carbon and nitrogen are sufficiently abundant as well as saline compounds, to generate cyanides, and, with hydrogen also there in plenty, hydrocyanates, and thus from them many other poisonous products, but how is all this to be effected? And even if effected, it is yet a question if such compounds can in any way simulate the attacks of epidemic disease. We have
already shewn that the amount of most poisons necessary to destroy an individual, can be pretty clearly estimated, and their modus operandi is tolerably well understood. Again, the most essential part, in which all chemical theory fails, is an explanation of the reproduction of contagious matter.
The catalytic process, by which decompositions are said to be effected, and in which Liebig includes the various fermentations, is one of those chemical relations of matter to matter, considered by some as the probable cause of infection. Mr. Simon, in a late lecture, has said, "I consider the phenomena of infective diseases, to be essentially chemical, and I look to chemistry to enlighten the darkness of their pathology. Qualitative modifications, affecting the molecules of matter as to their modes of action and reaction, are such as form the subject of chemical science; and those humoral changes which arise as the result of infection clearly fall within the terms of its definitions." Further on he adds: "The phenomena of infected diseases appears then, in many respects, to be sui generis. Certainly they are chemical. Probably they belong to that class of chemical actions called catalytic."[[52]]
It is not improbable that something resembling a catalytic action may take place in the blood in those diseases of endemic and epidemic origin, but that it can be by a chemical process alone is contrary to all experience of catalytic operations, for except in the instance of fermentation proper, there is no multiplication of the fermentative matter. The action of the matter of contagion seems to stand on the confines between electro-chemical and bio-chemical manifestations, and so long as no chemical explanation can be given for the multiplication of the matter of infection, the most rational course to adopt is to assume that life under some unknown form is, as we every where find it, the sole reproductive agent.
SECTION II.
THE ANIMALCULAR THEORY OF EPIDEMICS UNTENABLE.
The animalcular theory of disease, after remaining almost unnoticed for nearly two centuries, has been again revived under the auspices of Dr. Holland in this country, and Henle of Berlin. And though not entirely buried in obscurity, this theory had completely failed to modify the practice of physicians in the treatment of those diseases which were supposed to owe their existence to these invisible atoms of created being. The resuscitated notions and all their amplifications, to which the advance of science has contributed so much, are threatened with a like fate, an absence of all practical results.
Though I would not attempt to deny the possibility, nay, even the probability, that insect life may yet be discovered as the cause of some diseases,[[53]] still
there are many and cogent reasons against both, and which are at variance with facts and observations. Where insect life has been found associated with disease, it more especially appears as a consequence than as a cause.
Disease, in its most enlarged sense, is a conversion of one form of matter into another; it is a transformation of healthy blood and tissue into new and abnormal products. Where insects in all their variety of forms are discovered, their voracious propensities are their chief characteristics, they are the consumers of matter after its partial disintegration, if animal matter be their food, unless they be carnivorous and predacious, or if herbivorous they usually feed upon the tender shoots of plants. Thus far we are certain of the manner in which insects destroy living matter; it is a process the unassisted eye may every where witness, and which experience has amply attested. To take, however, the animalcular world as it presents itself to us under the microscope, and as the intermediate step between the manifest and the hidden for a fairer and more direct method of reaching the truth, what do we observe to be the ruling law of infusory instinct? They live to feed; the term polygastrica sufficiently implies their natural tendency to consume. The simplest form of animalcular life, seen in the genera of monads, still preserves the animal character by possessing a stomach or stomachs in which the food is received, to be digested for the nourishment of the
system; and even some of these minute objects which vary in size from one two-thousandth, to one three-thousandth of a line in diameter, are said to be carnivorous and predacious. Upon this fact alone, I would place the improbability of insects being the cause of epidemic disease. Each insect doubtless has its own peculiar food, and whether it be a vegetable or animal feeder, it consumes the matter already organized for conversion into its own tissue, and the only change which could be affected by them in the blood, would necessarily be that of appropriation of some one of the constituents as an element of food; when that food is digested, (taking digestion generally as an identical process,) the excrementitious matter is composed of secretions and disorganized matter, mixed together as an effete product, and destined then for reorganization by the vegetable kingdom. Now all animals, whether they be large or small, live on organized matter,—they convert that matter into an inorganic form, and I cannot help imagining that if epidemic diseases and fevers depended upon animalcular growth and development in the blood or tissues of the body, the excretions or secretions from them would have yielded some information to the searching enquiries of the chemist, supposing that these excretions and secretions were capable of reaching to a sufficient amount in quantity, to bring about those fatal effects of poisoning, we witness in Cholera and other epidemic affections. Insects, I
believe are poisonous only by their secretions, and though they are known to multiply with exceeding rapidity, I can hardly imagine that by their development, however rapid, they could produce such a change in the human body, as to bring about the speedy dissolution, and generally gangrenous appearance, that has invariably been observed in those suddenly dying under the influence of epidemic poisons. The vibriones, whose destructive effects on wheat are so well known, are a genus of animalcules, which at first would seem to favour the animalcular theory in a remarkable manner; for on examining them, they do not appear to possess any other structure than a gelatinous absorbing mass, in this respect resembling a vegetable.
But Ehrenberg's scrutiny corrected the error of De Blanville, and shewed, that they were far from being agastria, or stomachless animals. The Rev. William Kirby says, "Ehrenberg has studied the vibriones in almost every climate, and has discovered, by keeping them in coloured waters, that they are not the simple animals that Lamarck and others supposed, and that almost all have a mouth and digestive organs, and that numbers of them have many stomachs." All the discoveries indeed which have been made on the minuter forms of animal life, have tended to confirm the doctrine that the stomach is the exponent organ of an animal; that is, in all animals there exists, in a variety of modified conditions, a receptacle for food. Some of the
animalcules, however, are still supposed to exist by absorption, as the vinegar eel, vibrio anguilla,[[54]] but when we find that the law is, generally speaking, that the receptacles of food become multiplied in number in these minute beings, and the vibriones which were supposed to be stomachless, have been proved to emulate their associates in the number of these organs; it would be more reasonable to conclude that our imperfect vision is the barrier to their detection, rather than to suppose that they do not exist. Besides, when we are told on undoubted authority that some of the animals of this class, have as many as forty or fifty stomachs; the least we can do, is to allow that all of them possess, at least one digestive organ, though we may not be able to detect it.[[55]]
So far then for the consideration of animalcular structure: let us now more particularly enquire into their destructive habits, and their functions, inasmuch
as they may be supposed capable of engendering epidemic diseases and fever. The truly carnivorous animalcules, or those truly herbivorous in their instincts, we may presume to be beyond the limits of our enquiry. We have rather to do with those which take an intermediate position, namely, those which feed upon matter undergoing decomposition, or upon fluids containing organic matters in solution, or suspension. If we take Entozoa generally, they may be considered as most conveniently to be placed in this intermediate class; and here we find still the digestive apparatus, and more than this,—for upon the modifications of the organs appropriated to digestion is their classification founded. "Rudolphi divided the Entozoa into Sterelmintha, or those in which the nutrient tubes without anal outlet are simply excavated in the general parenchyma, and into the Cœlelmintha, in which an intestinal canal with proper parietes floats in a distinct abdominal cavity, and has a separate outlet for the excrements."[[56]]
How do these animals obtain their sustenance, and what changes can they produce upon the vital fluid of the body? Analogy is here our only guide. If the trichina spiralis is examined, it is found to be enclosed in a cyst containing fluid; and this is,
doubtless, the source of its nutriment, and contains in solution the elements for its nutrition; but in this instance there is no selection, and there can be no locomotion to an extent sufficient to imply searching for food, as the animalcule in its natural state, when taken from the human muscle, is found coiled upon itself, making about two and a half turns. The fluid of the cyst is thus in all likelihood prepared by endosmosis, for the immediate and appropriate nutrition of the parasite. The cyst is thus the part which performs the diseased process, the containing animalcule is merely the consumer of what is prepared for it by the cyst. And this would seem to be the rule with all parasites, of the encysted kind.
We have alluded to the vibriones which are found in the fluids of living bodies, and the trichina which is found in the solid muscle; we have now to refer to those which infest the cavities. It was, I believe, Ehrenberg, who shewed that the tartar which accumulates on the teeth is composed of the debris of minute animalcules; in fact, that it consists of calcareous matter, having once formed a portion of the structure of their bodies, the ubiquity of these creatures is therefore as much and clearly established as the lower forms of vegetation. The intestinal worms, of which perhaps the Tænia is the most curious and important to be noticed, are from the locality in which they are found, chiefly injurious by the irritation they set up, and by appropriating
to themselves the nutrient juices elaborated in the process of animal digestion, thus depriving the individuals they infest of that which was destined for their own nourishment. In this, as in all associated instances, the character by which these parasitic animals are marked is their consuming propensity. There is, however, one more observation to make upon parasitic growths; but the question is yet unsettled in what kingdom of nature is the acephalocyst, or hydatid, to be placed. Mr. Owen says, "As the best observers agree in stating, that the acephalocyst is impassive under the application of stimuli of any kind, and manifests no contractile power, either partial or general, save such as results from elasticity, in short, neither feels nor moves, it cannot, as the animal kingdom is at present characterized, be referred to that division of organic nature."
We thus arrive at the simple cell, and the multiplication of living beings by cell buds; it is the point at which the confines of the animal kingdom are reached, and at which we are driven to speculation. The hydatid lives like a plant, by imbibition; and procreates, like a plant, by budding, either endogenously or exogenously, as regards the original or parent cell.[[57]]
This condition of being, suggested the notion of Protozoa, or first animals, in the same way that the purely cellular plants, that is, each individual, consisting of a single cell, gave the idea of Protophyta, or first plants. Mr. Kirby thus expresses himself on this subject: "The first plants, and the first animals, are scarcely more than animated molecules, and appear analogues of each other; and those above them in each kingdom represent jointed fibrils."
Admitting, then, that animals as well as plants exist in the form of simple cells, and that their multiplication proceeds apparently upon the same principle in each, it is nevertheless abundantly manifest, that the cellular form of perfect individuals is infinitely more numerous in the vegetable than in the animal kingdom.
From the mosses downwards to the fungi, the whole structure of the plants consists of an aggregation of cells, more or less in number and complicate arrangement, until, through a variety of gradations, we reach the single cell as a perfect individual.
It is rather remarkable, that the lower forms of vegetables and animals seem to derive their nutriment from matter of a similar kind; and though the office of plants is as a rule, to convert inorganic into organized matter, it appears that some of the fungi may live as animals do on organic matter when in a state of solution. This, however, is uncertain; for we do not know what are the first signs of decomposition in organized bodies, and for aught we can tell, it may be perpetually going on; so far as the disengagement of carbon from the system is concerned, this is certain; but whether the nitrogenous compounds also are subject to a resolution into their elements in the living body, is another question, and not so easy of solution. The partially decomposed elements of animal structures are, however, particularly adapted for the nutrition of the lower forms of vegetation; it is, indeed, from the decaying organic matters that the fungi derive, it may be said, their entire food.
SECTION III.
SKETCH OF THE PHYSIOLOGY AND PATHOLOGY OF PLANTS AND ANIMALS.
Animals and plants depend for their existence upon a nutritive fluid, which permeates their structure; it is the element from which all their secretions are formed, and their organs are nourished.
The food of animals is composed of previously organized matters, and is conveyed into a reservoir called a stomach, where it undergoes a process of solution, previously to entering the circulation. At this period, the animal and the plant again present points of resemblance, the lymphatics or absorbent vessels take up the products of digestion, and convey them to the blood-vessels, where mingling with the current of the blood, they are conveyed to the lungs, there to undergo a process of oxygenation before they become fitted for the renovation of the tissues of the body. Such is the nature of the food of man, that it contains all the elements necessary and adapted for transformation into bone, muscle, brain, and parenchyma, as well as the other tissues of the body; besides other elementary matters, which, though they form a very insignificant portion of
animal textures, from their constant presence in the vital fluid, evidently perform some important offices in the general economy of life; they are partly, perhaps, occupied in forming constituents of secretions.
Plants do not require a stomach,—the humus or soil to which they are fixed is the laboratory, where the nutritive matter is prepared in a state fit for absorption by the spongioles of their roots, and these correspond to the lymphatics of animals; after being taken up by the spongioles, this new fluid mingles with the sap, and passes to the leaves or breathing apparatus of plants, where carbonic acid gas combines with the crude vital liquid, and converts it into a condition fit for all the offices to be performed by the plant: viz. the growth of tissues, and the elaboration of secretions.
The tissues, however, of plants, though more simple in their nature, present a much more varied character than those of animals, when the different species are compared.
The bones of animals which give them their form, are invariably constituted of phosphate and carbonate of lime, deposited in a matrix of gluten; muscle, nerve, brain, tendons, and ligaments, have nearly, if not completely, an identical composition throughout the whole range of the animal kingdom: their secretions, however, vary much more considerably, as also do the secretions of vegetables. But vegetable tissue may contain, as in the stems of
grasses, a considerable amount of silex, and some notable quantity of sulphur, and so essential to their existence is the former element, that they cannot live without its presence in the soil, and also with it an alkali, to render it soluble. A large amount of soda, is an invariable attendant upon the structure of marine plants, as potash is of those growing on the land.
Thus, whether we regard the health of animals, or vegetables, we discover, that besides the matters which are absolutely indispensable for the nutriment of the tissues which undergo rapid transformation, those of a more permanent and durable nature require in an almost insensible degree, a restitution of elements; and though not apparently absolutely necessary to preserve vitality in the being, yet have so marked an influence over it, as to indicate an extensive bearing of each individual part, on the whole associated entity.
The elementary tissues of both kingdoms have been traced, in whatever form they may be found, to a cellular origin. The minutest vegetable germ, is a cell containing a granular matter within it, and even man himself, in his embryonic state, may be represented as an insignificant point in the realms of space; and might be placed side by side with the smallest particle of living matter, without suffering by the comparison.
The laws by which the development of these elementary cells is regulated, so that each advances
to its limit, and fulfils its destination, is one of those inscrutable and overwhelming mysteries of nature, which leads the admirer of creation on and on into the abyss of the future, and fills his soul with aspirations for that time, when the veil of ignorance shall be withdrawn. But this is not my subject.
The organization of the two animated kingdoms, is then regulated by definite laws, and all matter, whether acting upon them as agents of nutrition or destruction, are equally under their dominion; to investigate and to endeavour to fathom some of these laws, is the aim I have in view.
The sap is to the plant, what the blood is to the animal,—the elements of nutrition and secretion are contained in it, and whatever interferes with its normal constitution by subtracting from, or adding to it, deteriorates its qualities, and retards or accelerates the functions of the individual. Excess or deficiency of the natural elements may also be a source of disturbance; if carbonic acid be too abundantly liberated in the soil, as Dr. Lindley expresses it, "plants become gorged;" and if, on the other hand, the elimination be too slow, they become starved. It has been also shewn, that plants though they give out oxygen from their leaves, do not throw it off as animals do carbonic acid from their lungs; but that this arises as a result of digestion, and the fixation of carbon in the system, and that they really respire oxygen as
animals do, and give off carbonic acid, both by day and night.
That light is the stimulant of the digestive functions, and that, therefore, during the day, the amount of oxygen thrown off, far exceeds the amount of carbonic acid liberated during the same period.
The great and important distinction between animals and plants is, that the former possess a nervous system, by which they are subject to a very extended series of psychological relations; it is in these chiefly, if not entirely, that we are to look for the distinctive and well-marked differences of diseased action. In animals there are special media of communication between the sources of dynamic power, and the parts upon which the force is exercised: and again, a return communication exists, which conveys impressions to the source of power, and to use a simple comparison, a system of telegraphing is in incessant and watchful operation. This force is influenced and modified in its action, when exercised in the regulation of nutrition, growth, and reproduction of tissues, by the passions and emotions of the mind. All the secretions and functions of the body are more or less susceptible of being accelerated, retarded or modified by the psychical relations of mind and matter. Though we are apt to imagine that in man alone, these phenomena obtain much importance—there can be but little doubt, that wherever a
nervous system exists, whether in the form of aggregated or diffused ganglia, the interdependence of force and organization, each upon the other, bears a certain and definite physiological comparison; the more aggregated the ganglia, the more close, intimate, and extensive the psychical connexions, and the gradations pass downwards, until they appear to be lost on the confines of the vegetable kingdom.
The diseases of plants and animals deserve a more careful comparison than, I think, has hitherto been bestowed upon them.[[58]] If the study of physiology, or an enquiry into the laws which regulate the functions of living beings in a state of health, has been materially aided by the intimate knowledge of vegetable physiology, which, from the simple structure of plants, so favours the experiments of the student, there is every reason to suppose that vegetable pathology may also lead us to an equally important and useful result.
It is quite certain, that if a healthy seed, or leaf-bud, be placed in such a situation, that, according to the laws known, it will in all likelihood germinate, if all the elements for its sustenance exist in the soil, and the temperature and hygrometric
condition of the atmosphere are adapted to it, a healthy plant will be the result. Light, heat, moisture, and soil are therefore to be considered as the agents required to exist in a certain balance, or proportion, in reference to the health or power of vitality of the plant. Within a certain amount of variation, health may persist in virtue of the power of selection, which appertains to the spongioles of the root in absorbing nutriment; and also as regards light, from the tendency which most plants have to accommodate themselves to any deficiency of this element, by presenting their leafy expansion in that direction where the most of its influence may be obtained. But beyond a certain limit an unhealthy condition sets in. If the soil contain not the inorganic elements, which are absolutely indispensable for the tissues of the plant, or even if they be there and not in a state to be absorbed, a dwindling and degeneration ensue; if light be deficient in quantity, pallor, feebleness, and elongation of tissue follow, with more fluidity and general softness of texture. These conditions of plants have their analogues in the ill-fed and ill-nourished children in some of our manufacturing districts; they are stunted and diseased. Transport a healthy country lad, with the bloom of health on his cheek, from his native hills and valleys, or woods and fields, to the stool behind a desk for eight hours a day, in a narrow street in any city, where the rays of the sun rarely penetrate, it will not be long before
the skin of the animal and the cuticle of the plant may be submitted for comparison, when both will testify to the importance of the solar rays, as an indispensable agent in supporting the normal processes of organic life. So far common observation is competent to a solution of the facts; but beyond this we come to the enquiry, what resemblances are there in the early conditions of plants and animals. Each originates from nucleated cells, endowed by the All-seeing Power with a blind impulse of progressive development; the most simple cell of a vegetable multiplies itself by a generation of new cells within it, when the parent dies, and liberates the offspring. Here progression is simply multiplication; it is, as it were, progression in length only. The original cell, however, of animals, which is styled the germinal vesicle, extends or becomes developed into dissimilar parts; and whatever may be the variety, all alike proceed from the original germ cell, and the tout ensemble of parts constitutes the one and indivisible whole; in this instance there is addition besides multiplication, tissues and organs are added in all variety, until the maximum of organic development is attained in the wonderful being, man.
Yet how many points of resemblance are there between the vegetable cell and the fully developed human being, in a physiological and pathological point of view. There must be nourishment to sustain both; both require a certain amount of light
and heat for their growth and increase, and are dependent upon various unknown causes for active and healthy existence; and when a certain time has expired, all alike return to a condition, in which the particles composing them are subject only to the dominion of the laws which preside over inorganic matter.
But during the existence of plants and animals, we discover other features of comparison; plants, as well as animals, are liable to disease; they are subject to functional and organic affections. The former, among plants, are usually traceable to atmospheric vicissitudes or irregularities, changes of situation, &c.; and in man to irregularities of diet, and mental and bodily excesses, as well as to atmospheric vicissitudes.[[59]]
The organic diseases of plants and animals depend upon a repetition, or continuance, of functional derangement. As a consequence of this, the nutrition and reproduction of tissues lose their normal and definite character, wherefrom an indefinite and abnormal result is obtained. There is a limit to abnormal productions, and they are apparently
subject to laws, though not yet understood. In animals, they may be either excessive development of natural tissue in natural localities, as obesity and fatty tumours; they may be natural products in unnatural situations, as fatty degenerations of muscular tissue; or altogether new and unnatural products, as tubercle and cancer.
In plants, from their greater simplicity of structure, organic affections are perhaps entirely limited to the two first forms of animal organic disease; viz. to undue development of tissue in natural situations, and to the formation of natural tissue in parts of a plant where they are not usually found in a state of nature. The variety of excrescences seen on the stems, branches, and twigs of plants, may be given as instances of the former; and the conversion of stamina into petals, as in double flowers, as an instance of the latter.
We derive our sustenance from vegetables, and they from us; they produce for us the soothing opiate and the deadly strychnia; we for them the animating ammonia, and the distortions and sterility of excessive culture; we engender in them, by the latter, debility, disease, and death; and in our turn we become their prey. All this indeed is but a cycle of events, that requires no learned mind to fathom, and to comprehend; it is a matter of every day occurrence, and, though perhaps not entirely unheeded, is not dwelt upon in the fulness of its bearings and importance.
Let us now consider the diseases of plants, as a study progressive to those of man; and as their physiology has so extensively served us, we may possibly also find in their pathology much material for instruction; not that it will be attempted to shew that the same diseases affect both kingdoms, but that diseases, though dissimilar in effects, may have similar sources.
Unfortunately, there are not many men in this country, who need go further than their own gardens to find abundance of disease among their fruit trees and vegetables. The vine, the apple and the potato, common to most gardens, will furnish specimens.
It is an error of a serious kind to suppose, that the parasites which infest plants are not essentially the cause, or, perhaps, more properly speaking, the elements of disease. I confine myself here to disease of parasitic origin, as that is the subject of which I am chiefly treating.
That parasitic growths are the elements of disease in some instances, is now beyond dispute. The experiments of Mr. Hassall, detailed in Part II. of the Transactions of the Microscopical Society of London, are most conclusive; and they are of that simple nature, that any one may convince himself of their accuracy, by a repetition of them from the directions there laid down.
He says, the decay is communicable at will "to any fruits of the apple and peach kind, no matter
how strong their vital energies may be, by the simple act of inoculation of the sound fruit with a portion of decayed matter, containing filaments of the fungi. We may use with success the sporules of such fungi; but in this case the decomposition does not set in so quickly; in the one case, the smaller filaments of the fungi have advanced several stages in their growth; while in the other, the sporules have yet to pass through the several stages of their development."
Mr. Hassan, however, seems to speak doubtfully as to the mode in which the disease becomes naturally introduced;[[60]] how the spores enter the fruit, "is not very clear—though probably, it is by insinuating themselves between the cells of which the cuticle is composed, or perhaps by means of the stomata, where they are present. I may here state that the experiments were made on fruit, while living, and attached to the tree."
But why should there be a doubt as to the parts by which the sporules of minute fungi enter the plant, when it is clear, that not only can they enter
by the spongioles, but by the stomata of the leaves, and mingle with the sap. It is true, that they make their appearance and grow upon the leaves and the fruit; but these are the situations most adapted for their fructification. I have seen the spores of the fungi which attack the cucumber and vegetable-marrow, in the cells of the hairs, and even their filamentous prolongations; these appropriate the fluids conveyed to the cells of the hair, rupture them, and at length fructify.
On referring to Dr. Lindley's Medical and Economic Botany, I find that many fungi are the active elements of disease, and in a manner which renders it highly improbable that they are so in any other way, than by obtaining an entrance to the sap of the plants. Of the microscopic fungus which destroys wheat, the Uredo caries of De Candolle, we find the habitat to be within the ovary of the corn, and that 4,000,000 may be contained in a grain of wheat,—now this and another fungus, the Lanosa nivalis, are said to destroy whole crops of corn: we cannot imagine that such an extensive affection, can have any other source than by means of the spores through the sap, seeing that bruising of the surface, or rupture of the cuticle of the apple, a comparatively soft fruit is necessary to produce the disease artificially in them; besides, a grain of corn containing vibriones, when grown and having fruited, the new fruit also contains them—now here, as this is I believe almost invariably the
case, either they or their ova must be carried with the sap to the new germs.
It is rather a remarkable fact, that these entophytes appropriate the nutriment destined for the plant in which they grow, they are consequently the means in many instances of its entire destruction, though only partially so in others.
There are many Fungi which have this tendency. The Puccinia gramienis, "preys upon the juices of plants, and prevents the grain from swelling." The Æcidium urticæ, common on nettles, deprives the plant on which it grows, of the organizable matter, intended for its own nutrition. The Erysiphe communis, overruns and destroys peas. The Botrytis infestans, "attacks the leaves and stems of potatoes." The Oidium abortifaciens, attacks the ovaries of grasses—and the Oidium Tuckeri, "a formidable parasite, destroys the functions of the skin, of the parts it attacks." The latter has been most injurious to the vines, during the last two years. I have known instances in which the vines have been cut down, and every means taken to rid the houses of the disease; but this year, it has made its appearance, with all its former virulence, in the new shoots.
This, however, is sufficient to shew that plants are liable to disease, depending upon parasitic growths, which affect their vital powers, and deprive them of their natural nutritive fluids.
But somewhat similar diseases belong also to
warm climates; in a letter from Cuba, dated Dec. 1843,—Mr. Bastian writes, "a plague has appeared among the orange trees—a mildew attacking the leaves and the blossoms, which finally dry up. It most frequently kills the trees. None of the orange family are exempt; lemons, limes, and their varieties, with the shaddock and forbidden fruit, have all suffered." This disease has continued without intermission, till the present year,—when the same gentleman writes, Feb. 20th, 1850: "The evil exists, although in a diminished degree, so much so, as to have allowed the trees to produce me 30,000 oranges again. In old times, the same plantations produced me 100,000."
The West India sugar-canes are also liable to a disease, which the Rev. Mr. Griffiths, in his Natural History of the Island of Barbadoes, speaks of, in the following manner: "This, among diseases peculiar to canes, as among those which happen to men, too justly claims the horrible precedence." This disease is called the Yellow Blast. It is difficult to distinguish the Blast in its infancy, from the effect of dry weather.
There are often seen on such sickly canes, many small protuberant knobs, of a soft downy substance. It is likewise observable, that such blades will be full of brownish decaying spots. The disease is very destructive to the canes. It is observed, that the Blast usually appears successively in the same fields, and often in the very same spot of land.
This Blast is often found far from "infected places," and the infection always spreads faster to the leeward, or with the wind.
"It is remarkable if canes have been once infected with the Blast, although they afterwards to all appearance, seem to recover; yet the juice of such canes will neither afford so much sugar, nor so good of its kind, as if obtained from canes which were never infected."
I may here allude to the circumstance, that in the island of Cuba, the destructive mildew is commonly called, la pesta.
It were needless to multiply instances of other endemic and epidemic diseases of vegetables; they are well known by practical observers to be very numerous, and I believe, in most instances, depending upon fungoid growths. The destruction of vegetables by insects, is of a very different nature to that produced by the fungi; it would be as unreasonable to consider the consumption of corn and herbage by locusts, as a disease of vegetation, as the massacre and devouring of human beings by cannibals, a disease of the human body.
It is true that insects are exceedingly destructive to plants, but as far as I am able to obtain information, they appear to be so chiefly by their voracious propensities; they consume the structure of the plant in its entity, and do not primarily interfere with its vitality. The instance of the vibriones, before-mentioned, seems at first to be an exception
to the rule, but this is rather apparent, than real; and it may be made to apply more as a confirmation, than an obstacle to the vegetable theory: for if we may fairly compare the diseases of animals with those of plants, the existence of entozoa in the latter, would be considered an essential point to be substantiated.
Having now considered the question as to the infeasibility of supposing that chemical fermentation is the basis upon which a theory of diseases can be sustained, and having shewn that life is inseparable from infection, and miasmatic generation;—having explained the phenomena of the dispersion of diseases by comparison with the dispersion of plants, and finally, having demonstrated that the physiology and pathology of plants bear so close a relation to each other, and that their epidemic affections depend upon minute organic germs, I submit to the judgment of my readers, whether there is not much reasonableness in the application of the facts to the inference—that living germs are the cause of epidemic disease in man and animals.