HOW RADIUM IS CONVERTED TO LEAD
Lead is produced from uranium by a successive series of losses of Alpha particles—or helium atoms. Omitting the less essential outcomes, or transition stages, we find that each atom of uranium spontaneously ejects three atoms of another element, helium, and thereby is converted into still another element, radium. By losing one atom of helium, radium, in turn, is converted into the so-called emanation, or niton. The latter quickly loses four more atoms of helium and is converted into lead, “uranium lead,” having an atomic weight of 206.08. Ordinary (common) lead, constituting the vast bulk of the lead of the world, has a much higher atomic weight, namely, 207 (Prof. Theodore Richards). Lead from thorium has an atomic weight of 208; from actinium, 206. So we have, in fact, four kinds of lead.
Omitting the less stable transition products, we may say, then, that an atom of uranium is converted into lead by the loss of eight atoms of helium—losing three to become radium, then one to become the emanation, and finally four to become lead. No known human agency can either retard or hasten this breaking down of the uranium atom into radium, or of the radium into emanation, with the final production of lead.
This statement has been universally accepted as true. Nevertheless, Dr. A. Glaschler stated (Nature [London], September 12, 1925) that he had succeeded in accelerating the change of uranium to uranium X (the first product of uranium 1) by submitting uranium oxide to “strong rushes of momentary high-tension currents.” As early as 1923, A. Nodon (Comp. rend., 176, 1705 [1923]) brought forward strong evidence of an increase of the activity of radioactive substances when outdoors and enclosed by envelopes of small absorbing power for Gamma rays as contrasted to the smaller radioactivity of the same substances in cellars and when heavily enveloped by lead. For a tentative explanation of this phenomenon, see Science, January 8, 1926 (Vol. LXIII, No. 1619), pp. 44–45.
Both uranium and thorium, as we have just stated, break down and become radium, then change to helium and lead.
Says Rutherford: “Although thorium is nearly always present in old uranium minerals and uranium in thorium minerals, there does not appear to be any radioactive connection between these two elements. Uranium and thorium are to be regarded as two distinct radioactive elements.
“With regard to actinium, there is still no definite information of its place in the scheme of transformations. Boltwood has shown that the amount of actinium in uranium minerals is proportional to the amount of uranium. This indicates that actinium, like radium, is in genetic connection with uranium....”
The recently discovered product, protoactinium,—isolated by Hahn and Soddy,—is the hitherto missing link between uranium Y and actinium. “This substance emits Alpha rays and has an estimated period of 10,000 years. The actinium series is believed to have its origin in a dual transformation of uranium X. The first branch product, representing about 4% of the total, is believed to be uranium Y, a Beta-ray product of period one day. This is directly transformed into protoactinium.” This element has not yet been obtained in a pure state.
Many of the radioactive elements are isotropic with known chemical elements—i.e., alike in their chemical properties, but dissimilar in radioactive properties. Since they cannot be distinguished—or separated—from the ordinary elements with which they are isotropic, by any chemical methods, they must occupy the same place in the periodic classification of the elements. Radium and mesothorium, for example (as Soddy was first to show) do not have the same atomic weight, but they cannot be distinguished from each other by any chemical methods. Therefore they both have the atomic number 88, though the atomic weight of radium is 226 and of mesothorium 228. (See Shipley, “Origin and Development of the Atomic Theory,” p. 64, Little Blue Book, No. 608.) Radium D and lead, and thorium and ionium, are examples of radioactive isotropes.
The nature of the end-product was first suggested by Boltwood, who pointed out the invariable presence of lead in old radium minerals, and in amount to be expected from their uranium content and geologic age. “Thus,” says Prof. T. W. Richards, of Harvard University, “we must adopt a kind of limited transmutation of the elements,” although not of the immediately profitable type [gold] sought by the ancient alchemists.”
Sir Ernest Rutherford, who succeeded Sir J. J. Thomson as Cavendish Professor of Physics at Cambridge University, was first to recognize that the rays from uranium and radium were not all alike, but consisted of three distinct kinds. In order to distinguish them clearly, without committing himself in advance as to their exact nature, he christened them Alpha, Beta, and Gamma rays—the first three letters of the Greek alphabet. We know now that the Alpha rays are positively charged helium atoms, with two negative electrons missing; that the Beta rays are negatively charged electrons (disembodied “particles” of electricity, exactly like cathode rays); and that the Gamma rays are a type of X-rays, not material particles but merely extremely short magnetic waves or oscillations, akin to ordinary light waves or rays.
Dr. R. A. Millikan calls them “the wireless waves of the denizens of the sub-atomic world. They are ether waves, just like light or just like wireless waves, except that the vibration frequency ... amounts to 30 billion billions per second. These are the Gamma rays.” This means that this number of light waves would pass a given point in space each second. Since these rays do not consist of charged particles they are not deflected by electromagnetic or electrostatic fields, as are the Alpha and Beta rays. It has been found that one gram of radium ejects 136,000,000,000 particles a second!
The Gamma rays of radium have such penetrating power that a half-inch sheet of lead will reduce their original intensity by only one-half, and they are not absolutely stopped by 20 inches. These invisible light waves, thousands of times shorter than those of visible light, are produced whenever a cathode ray (negative electron) hits matter. Of the atoms forming the substance penetrated, perhaps only one in a billion is struck. It has been said that the Gamma rays (and X-rays) are the result of the back-kick of ejected electrons. Prof. Comstock says that the connection between the Beta rays and the Gamma rays “is probably similar to that between the bullet and the sound in the case of a gun.” However this may be, we know that the Gamma rays are, after all, in essence only excessively minute light waves. While the longest visible light waves are 0.00008 centimeter, the longest Gamma rays are 0.000000013 centimeter; and whereas the shortest visible light waves are 0.00004 centimeter, the shortest Gamma rays are but 0.0000000007 centimeter.
The Beta particles are ejected with a velocity of from 90,000 to 160,000 miles a second.
Prof. Gustave Le Bon calculated that it would require 340,000 barrels of powder to discharge one bullet at this inconceivable speed! These negatively charged electrons normally revolve around the positively charged nucleus. Under certain conditions, an electron will make 2200 billion revolutions within an atom in one second.
Radium is not only continually losing matter and energy as electricity, but it is also losing energy as heat. Professor and Mme. Curie discovered that any substance placed near radium becomes itself a false radium. This applies to all substances. The acquired radioactivity persists for many hours, or even days, after the removal of the radium. In the case of zinc, these secondary radiations were found to be four times as intense as ordinary uranium. It vanishes sooner or later upon the removal from the neighborhood of the potent radium.
The radioactive something which passes out of radium was not the already known group of Alpha, Beta and Gamma rays, but an emanation akin to gas. Rutherford, its original discoverer, was not sure that it was a gas, so he cautiously gave it the name emanation. When the radium was heated, or dissolved in water, the quantity of emanation was greatly increased, which seemed to show that it was a gas of some kind occluded (bound up) in the radium. The quantity obtained was insufficient to bring the emanation within the testing power of spectroscope or balance.
Nevertheless, the emanation has been detected, and investigated by the electroscope, which measures the radium rays by the power to discharge its electrified gold leaves. “The electroscope is about a million times more sensitive than the most sensitive spectroscope and yet the spectroscope is capable of detecting easily the millionth part of a milligram of matter” (Duncan).
Calculations made by Rutherford show that if a thimbleful of this active gas could be collected, the bombardment of its powerful rays would heat to a red heat, or even might melt down, the walls of the glass containing it. The emanation emits only Alpha rays (or particles) forming helium.
The radium from which the emanation has been abstracted, after the lapse of an hour or so, loses 75% of its activity. During the course of a single month, radium will be found to have restored all its lost emanation. In thirty days it will have regained all its original activity. It was soon discovered that the emanation abstracted from the radium loses its radioactivity at the same rate and according to the same laws as the de-emanated radium regains it. The radium is therefore said to be “in equilibrium with its products.”
Since these processes are wholly outside the sphere of known controllable forces, and cannot be created, altered or destroyed—“since the process is independent of the chemical form of the radium, whether bromide, chloride, sulphate, etc., we are absolutely shut up to the conviction that it is a function of the atom. We are in the presence of an actual decay of the atom. The atom of radium breaks down into atoms of emanation and the atoms of emanation in their turn break down into something else. The activity of emanation decays and falls to half value in about 3.7 days.”
Although the amount of emanation produced from a gram of radium does not amount to more than a needle-point of the gas (= 1.3 cubic millimeter), this is sufficient to raise the temperature of 75 grams of water 1° per hour, which is enough heat to melt more than its own weight of ice in an hour, and to raise it to the boiling-point in the next hour, which is equivalent to 60,000 horse-power days! In other words, the heat evolved by the radium emanation is more than 3,500,000 times greater than that produced in any known chemical reaction: such as, for example, the union of oxygen and hydrogen to form water.
It was soon discovered that if the spectrum of this mysterious gas—or radium emanation—be examined again after an interval of about four weeks, it has changed into a familiar spectrum easily recognized as that of the gaseous element known as helium. Here the chemist comes face to face with the astounding fact that the element radium is decomposed and produces another element, helium—a discovery made by Ramsay and Soddy in the summer of 1903.
In the successive radioactive changes, one Alpha particle (sometimes called “ray”) is ejected from each atom disintegrated by the change—in some cases, at least, accompanied by Beta particles (negative electrons). The Alpha particle, as already stated, is really an atom of helium carrying two atomic charges of positive electricity—twice that of an atom of hydrogen. Strictly speaking, the Alpha particle is only the nucleus of a helium atom, since it has lost two of its negatively charged electrons, which are combined in the ordinary helium atom. The exact velocity of the expelled Alpha particle “varies in the different radioactive elements” (Joly)—say from 10,000 to 18,000 miles each second—a velocity sufficient to carry the particle around the earth in less than two seconds, if unchecked.
But these relatively heavy particles (of atomic size) are actually soon checked, even by seven centimeters (about a third of a foot) of air. The Beta particle (1,845 the mass of a hydrogen atom) “shoots a hundred times as far [as the Alpha particle] and the Gamma rays are a hundred times more penetrating still” (Millikan). But the Alpha particle is sometimes ejected with a velocity nearly 40,000 times that of a rifle bullet,—the velocity of the latter being about half a mile a second. Even the super-guns which bombarded Paris could not eject a projectile with a speed of more than about a mile a second. Rutherford observes that if it were possible to give an equal velocity to an iron cannon ball, the heat generated on a target would be many thousand times more than sufficient to melt the cannon ball and dissipate it into vapor.
The flashes of light seen when the Alpha rays bombard a screen of zinc sulphide, as in Crookes’ spinthariscope, are due to cleavages produced in the zinc sulphide crystals by the impact of the Alpha rays (positive ions). Each impact on a crystal produces a splash of light big enough to be seen by a microscope.
In the phosphorescence caused by the approach of an emanation of radium to zinc sulphate, the atoms throw off the Alpha (helium) particles to the number of five billion each second, with velocities of 10,000 miles or more a second. If the helium projectile should chance to “crash” into an atom of nitrogen or of oxygen, an atom of hydrogen can be knocked out of it, as was discovered by Sir Ernest Rutherford, perhaps the most distinguished of Mme. Curie’s pupils. (Strictly speaking, the disintegration particles are isotropes of helium, of atomic weight 3, the atomic weight of helium being 4.) Despite its large size as compared with an electron (or Beta particle), the Alpha particle passes through a glass wall without leaving a hole behind, and without in any way interfering with the molecules of the glass. It shoots through hundreds of thousands of atoms without ever going near enough to them to be deflected from its course.
CHAPTER V
RADIUM IN THE TREATMENT OF CANCER
The action of radium on human tissues was unknown until 1896, when Prof. Henri Becquerel of Paris, having incautiously carried a lump of pitchblende in his pocket, discovered on his skin, within two weeks, a severe inflammation, or ulcer, which was known as the famous “Becquerel burn.” As physicians of the nineteenth century were accustomed to burn out cancers with caustics, the idea occurred to them that the application of radium might prove to be an improvement on the older method.
It has proved to be so, affording in many cases not only relief, but in some instances, even a cure, not only for cancer, but for many other ailments—as we shall see presently. Since that time active investigation into the action of radium on diseased tissues has been carried on, resulting in the establishment in Paris of the “Laboratoire biologique du Radium,” and also of the Radium Institute of Vienna, followed by the establishment of somewhat similar institutions in various other countries, notably in England and the United States.
One of the most famous institutions for radiotherapy is the recently established Radium Institute of Paris, under the management of Mme. Curie and Professor Debierne. This is composed of two distinct compartments. In one the scientific properties of radium are studied, while the other is devoted to its therapeutic applications. Dr. Regaud, who is in charge of the latter department (a branch of the widely known Pasteur Institute), endeavors to cure cancer and tumors by application of radium and X-rays.
New York City boasts a magnificently equipped Radium Institute, under the directorship of Dr. C. Everett Field. And an even more famous institution is that founded by the Mayo brothers, in Rochester, Minnesota, where these eminent surgeons had accumulated an entire gram of radium as early, at least, as 1920—the largest amount owned by private individuals. This great institution—now known as the Mayo Foundation—is no longer privately owned, but it is still under the direction of the Mayos.
Radiotherapy (or, in France, curietherapy, in honor of the discoverer of radium) or the treatment of various diseases by radioactive substances, has not been applied so extensively as has treatment by X-rays (Roentgen rays), produced in vacuum tubes. On the other hand, the X-rays are not so effective (as usually applied) in the treatment of certain morbid conditions as are the more penetrating Gamma rays from radioactive substances; though the latter are essentially identical with X-rays—swift Beta particles, or negative electrons—of very short wave-length. To produce X-rays as penetrating as the Gamma rays, about two million volts would have to be “cut” on the discharge tube.
The Alpha rays are not often used in medical practice, and have little penetrating power. They are stopped by 3½ cm. of air, or by a thin sheet of paper. They are employed only in the way of radium “emanation” (a gas) dissolved in saline solution, or by the use of needles upon which active deposit from radium emanation has been collected. “In either case the emanation water or the active deposit needles must be introduced into the system—whether intravenously or into the solid tissues,—otherwise the Alpha rays would have no power to act. In either case, too, they act along with the Beta and Gamma rays produced by the active deposit” (Lozarus-Barlow).
Beta radiation is used only for superficial conditions and always in conjunction with Gamma radiation. “Instead of a radium salt, one of its products, viz., radium emanation, is often employed chemically. No essential difference is introduced by the use of this emanation excepting that its intensity undergoes a progressive diminution with time, since it falls to half value in 3.85 days. Early rodent cancer, certain conditions of the eyelids, some cutaneous non-malignant tumors and birth-marks, are treated successfully in this way.”
Physicians of the Memorial Hospital, New York City, announced in October, 1925, that by filtering out 90% of the caustic Beta rays emanating from radium and the high voltage X-ray tube, and using principally the healing and stimulating Gamma rays, radiation treatment of cancer of the tongue, lips, nose, ears or other part of the head has been greatly improved.
In the first six months after the new method was begun, more than 100 cases had been treated with what were considered very satisfactory results. Owing to the elimination of the caustic rays, much stronger applications of the beneficial rays can be used, and painful effects are largely obviated.
If experience and special research lead eventually to successful treatment of cancer, it will be a great boon to the human race. The United States leads the world in deaths from this dread disease, with its average of 90 per 100,000 of the population. The mean average of cancer deaths in Europe is 76, in Asia 54, in Africa 33, in Oceania 73. Several races, including the American Indians, are stated to be entirely free from cancer, and others are partially immune. The Japanese, for example, are subject to all forms except cancer of the breast. Eighty-five percent of Americans afflicted with this malady are persons over 40 years of age.
Science Service states that a careful analysis of cancer statistics gathered by the United States Census Bureau over a period of about 20 years in ten Eastern states reveals definitely that cancer mortality is from 25 to 30% higher than it was about 20 years ago. This is the claim of Dr. J. W. Schereschewsky, of the United States Public Health Service, who made the statistical analysis and reported it to the American Medical Association. “There has been a pronounced increase in the observed death rate from cancer in persons 40 years old and over in the ten states comprising the original death registration area,” Dr. Schereschewsky said. “Part of this increase is due to greater precision and accuracy in the filling out of death returns, but the remainder is an actual increase in the mortality of the disease.”
The only way to stop the ravages of cancer, says the Paris Academy of Medicine, is to diagnose it early—in time for operation. For this to be practicable, physicians must be specially instructed. Family doctors are often ignorant of all but a few forms of cancer and do not recognize it in its first manifestations. Women of 40 to 50 are apt to consider little irregularities of bleeding to be associated with the menopause and therefore harmless. Often this is right, but unfortunately the bleeding from an early cancer may not differ in the slightest degree from such harmless irregularities and by the time other symptoms have developed, the cancer has perhaps grown through the wall of the uterus and has spread to regions where no treatment can hope to reach it. The only safe rule to go by is to seek expert investigation for any unusual or irregular bleeding or discharge, however slight, especially if these occur at or near the “change of life.”
One phase of this subject of special interest is that of the use of radium in the treatment of cancer, especially of the neck or lower end of the uterus. There is already sufficient evidence to warrant the statement that some cancers of this region have been permanently cured by radium alone. And as a relief measure in the late and hopeless stages of the disease, radium prolongs life, relieves pain and adds much to the comfort of the victim.
It has been amply demonstrated that radium treatment increases the permanency of the results obtained by surgery, and often converts inoperable into operable cases.
CHAPTER VI
EFFICIENCY OF RADIUM IN TREATMENT OF VARIOUS DISEASES
In 1923, Dr. R. E. Loucks, president of the American Radium Society, announced that toxic goiter had been cured by radium. Exophthalmic goiter has been, in most cases, successfully treated by irradiation. Just how the cure is effected is still unknown; for the thyroid body from animals exposed for many hours to the Gamma irradiations of radium bromide shows no perceptible histological changes. Yet far less radiation produces marked changes in the tadpoles derived from normal ova fertilized by spermatazoa which have been radiated in the frog, though no testicular changes can be detected with certainty (Encyclopaedia Britannica, Vol. 32, p. 224, 12th Ed.).
Among other diseases which have been more or less successfully treated by radium may be mentioned lupus vulgarus, epithelial tumors, syphilitic ulcers, chronic itching of the skin, papillomata (an epithelial tumor formed by hypertrophy of the papillae of the skin or mucuous membrane, as a corn or a wart), angiomata (tumor composed chiefly of dilated blood or lymph vessels), pigmentary naevi (blemish of the skin due to pigment, as a birth-mark), and pruritus (itching). Radium has been particularly effective in treating serious affections of the eyes, as was first fully demonstrated by Dr. Walter S. Franklin and Frederick C. Cordes, of San Francisco.
The most brilliant successes of radium have been in those cases “where some serious complicating ailment, such as heart disease, tuberculosis, Bright’s disease, or an extreme anemia, contra-indicates anesthesia or any procedure which will tax the patient’s vital resources; radium steps in and does its work quietly, imperceptibly and, indeed, without the slightest risk to life.”
Dr. Howard A. Kelly, of Johns Hopkins University, has been very successful in curing swollen masses of glands on the sides of the neck, cancer of the thyroid and of the cervix, and sarcoma of the chest. Dr. E. S. Molyneaux of London, has cured obdurate cases of tubercular glands in the neck, a disease rather frequent among children. Thanks to the patient researches of Dr. John A. Marshall, associate professor of biochemistry and dental pathology at the University of California, it is now known that a radioactive liquid may be used for sterilizing infected tissue. Experiments employing the radioactive liquid in the treatment of root canals have been conducted at the George Williams Hooper Foundation for Medical Research and at the College of Dentistry of the University of California.
Within the time that the new antiseptic has been in use at these colleges, 85% of all the cases treated have been successful; and, with one exception, no soreness or pain has followed its use. This radioactive preparation is a solution of radium salts, “Radium D plus E,” which results from the decomposition of radium emanation, which, readily soluble in water, possesses definite radioactive properties. In making the solution the tiny capillary tubes containing the decomposed radium are crushed under water in a mortar and the liquid is then ready for use in the treatment of an ulcerated root of a tooth.
Dr. Marshall had been working with radium for months before admitting the success of his investigations, which were conducted in a long series of experiments on the lower animals. “Microscopic examinations of abscessed tissue,” he said, “which have been treated with radioactive solutions, indicate that the bacteria producing the affection were killed. And in no cases observed has the treatment produced radium burns; the amounts used have been too small and the effects of too transitory a nature. That sterilization of tissue can be produced, however, seems apparent.
“The discovery is purely of academic interest because of the fact that radium is too expensive, and it is possible to obtain it only in limited quantities; so that the chief value of the discovery will rest in the fact that it will stimulate further work for the identification of more accessible material.”
In external treatment by radium itself, emanations from a certain quantity of radium are allowed to focus on parts of the body over the diseased organs. Thus the curative functions of the diseased portion are stimulated to activity. The atrophying of diseased tonsils has been the most successful use of this form of treatment.
In the destruction of disease germs the radium emanation has been found more useful than the direct rays. The emanations kill or check the growth of anthrax, typhoid, and diphtheric germs. The direct rays are efficient in the relief of severe cases of enurites and facial neuralgia, cancer, tumors, affections of the skin and abnormal growths. Dr. Guyenot has proved that radium effects a complete cure for rheumatism, which he accounts for in these words: “Uric acid circulates in the blood in the form of urate of soda, of which there are two isomeric forms differing from each other by their respective solubility in the blood plasms. The soluble salt is converted into an insoluble form.” Radium breaks up this compound. The “rheumatism” disappears.
CHAPTER VII
WHERE WE GET RADIUM
The extraction process consists in eliminating the various substances in the ore until only the radium salts are left. But, in the case of carnotite, more than 900 different operations, requiring six months of labor, are required between the digging of the ore and the production of a gram of pure radium salt. A solution containing barium and radium salts in the ratio of ten parts of radium to a billion is treated with sulphate to precipitate an insoluble “raw sulphate of barium.”
Radium ores are generally found in connection with granitic masses—i.e., in places where granite forms at least part of the rock of the country. The carnotite ore usually consists of a thin layer of sandstone which crops out on the side of a canyon wall and is recognized by the characteristic sulphur-yellow color. The narrow seams are usually in the form of pockets, so that the value of a claim is dubious until it has been thoroughly explored and worked.
Most of the original radium minerals, such as uraninite, samarskite, and brannerite, are black and have a shiny fracture and a high specific gravity. These minerals are, however, rarely found in commercially valuable quantities.
Pitchblende, the richest source of radium, has the same composition as uraninite and the same general appearance, except that it shows no crystal form. It occurs in veins. There are extensive deposits of pitchblende or uraninite at Joachimstahl, Bohemia (Czecho-Slovakia), containing from 30 to 70 per cent uranium oxide, from which the radium is extracted. But here the uranium ore occurs in small pockets in widely separated localities, so that it is merely a by-product of other mining operations. However, after separation of the uranium from the ore, the residues are three to five times as radioactive, weight for weight, as the uranium. The amount of radium in old unaltered mineral is always proportional to its content of uranium in the ratio of 3.3 parts of radium by weight to ten million parts of uranium.
New radium ore fields were discovered in Czecho-Slovakia in 1922. The production of radium in that country increased from .7746 gram in 1911, to 1.7118 grams in 1915, and 2.2310 grams in 1920. In 1922, steps were taken to modernize the plants in the Jachcymov district (Bohemia), where the known supply will last 20 years at the present rate of production—a little more than two grams a year.
The famous Joachimstahl pitchblende deposits were a monopoly of the Austrian Government before the World War, but they are now being worked by the Imperial and Foreign Corporation of London, under an agreement with the Czecho-Slovak Government. In 1922 a loan of two grams of radium (valued at more than $300,000) was made to Oxford University, for a period of fifteen years. This material is being used for experimental purposes by Prof. Frederick Soddy, of Oxford, and his associates. It has been stated that one of the chief objectives is the discovery of a method for the release and control of intra-atomic energy.
Pitchblende has been found in only a few places—in Bohemia (Czecho-Slovakia), southern Saxony, Cornwall, and Gilpin County, Colorado. So far, this ore has not been the source of any radium produced in this country.
When the original radium minerals (uraninite, samarskite, brannerite, etc.) break down through weathering, other radium minerals are formed from them, such as autunite, trobernite, carnotite, and tyuyamunite. The two latter ores are the most widespread and abundant. Autunite, a phosphate of calcium and uranium, is as active as uranium. Carnotite and tyuyamunite cannot be distinguished visually from each other. Both are a bright canary-yellow in color, and are powdery, finely crystalline, or, rarely, clay-like in texture. Both these minerals are found in the same section of Utah and of Colorado, usually associated with fossil wood and other vegetation, in friable, porous, fine-grained sandstone.
The only other deposits that yield tyuyamunite in marked quantity are those of Tyua-Muyun, in the Andiyan district, Ferghana Government, central Asiatic Russia (Russian Turkestan), where it occurs with rich copper ores in a pipe in limestone.
The radium salts—hydrous sulphate, chloride, or bromide—are all white or nearly white substances, no more remarkable in appearance than common salt. Neither radium nor the radium minerals are in themselves luminescent. Tubes containing radium salts glow because they include impurities which the invisible radiations from the radium cause to give light. The pure radium metal has been isolated only two or three times, and few persons have seen it.