Constantinople (Ottoman Invasion of Europe).
On June 10, 1422, Amurath II, with 200,000 Turks, laid siege to the city, which was defended by the Greek garrison under the Emperor Manuel. After a siege of two months, in which the Turks lost heavily in their numerous assaults, and in the defenders' sallies, Amurath[, Amurath] was called away to Boursa by a domestic revolt, and raised the siege.
On April 6, 1453, the Turks again laid siege to Constantinople with 258,000 men under Mohammed II. The garrison, consisting of 5,000 Greeks and 2,000 foreigners, though short of ammunition, made a gallant defence, but were overpowered by numbers in a general assault on May 25, and the city was captured. Constantine Palæologus, the last Emperor of the East, was killed by an unknown hand, in the tumult which followed the storming of the ramparts.