FOOTNOTES:
[11] This was first at Bush Hill, and subsequently at the Sugar House, near the Alms House.
[12] The largest proportion of these deaths was in the six months from the 1st of November, 1823, to 1st of May, 1824, being in that period about four hundred.
[13] Kept by Reuben Haines, at Germantown, seven miles from the city. The thermometrical mean is that from daily observations made by this gentleman at sunrise and at 2 P. M.
[14] Of these 165 were by yellow fever.
[15] The deaths from inflammation of the different viscera, were as reported in this year, 290, and from infantile flux and cholera morbus, 177.
[16] Same proportion of inflammations as last year, viz. 339.
[17] Should it be hereafter necessary, we can illustrate other varieties of the disease by drawings which were taken at the same time with those, of which coloured engravings are now furnished.
Article IV.—Remarks on the Pathology and Treatment of Yellow Fever. Arranged from the Notes of Dr. J. A. Monges, of Philadelphia.
I arrived at St. Domingo in the year 1785, and from that period to the time of my departure from thence, I had very ample opportunities of observing and treating the diseases of that island, both in the country and at the Cape. During the whole time of my residence there, the ordinary febrile diseases of hot climates were of very frequent occurrence, especially among the new comers, and those not acclimated; but the real yellow fever, or vomito negro, never prevailed. So that when I reached this city in 1793, I never had had an opportunity of observing this disease.
As introductory to the subject more particularly before us, I shall offer a few remarks on the nature and treatment of the fever, which prevailed in that island. It was usually of the remittent type, of a bilious nature, and rather violent in its character; presenting very often symptoms of a typhoid, or malignant condition of the system. In almost every case, it was attended with great gastric irritability and pain; and, in very many instances, accompanied with vomiting of dark green, and even of black bilious matter,—determination to the brain producing delirium, coma, &c. &c. In general, this fever differed but little from the bilious fevers of this country; except, perhaps, in its greater severity, and in a larger quantity of bile commonly evacuated. The treatment of this disease, at the time of my arrival, was generally attended with some difficulty, owing to the great prejudice prevailing against the use of the lancet; not only among the mass of the population, but even among the old physicians of the island. Experience, however, having taught me, that venesection was essentially necessary in fevers of the same sort, which I had noticed in other places, I resorted to it, notwithstanding the existing opinion; and am now convinced, that by its means I saved many patients. Nor was I the only one to adopt this mode of practice; as it was commonly resorted to by all new physicians, who were soon found to be more successful than the older practitioners. To arrest the violent vomiting, already alluded to, it was of the highest utility, and, in many instances, the only remedy that could be depended upon. Emetics were very commonly used, and sometimes with great benefit; but, in many instances, they were contraindicated by the pain and irritation of the stomach.
Cooling and saline purgatives were advantageously employed, as well as the saline mixture, and nitre and camphor in small and repeated doses, a very favourite practice in the place. In a more advanced period, and when the fever assumed a typhoid type, blisters, bark, and serpentaria were resorted to.
I arrived in Philadelphia on the 20th of August, 1793, and on the 22nd of the same month, began to see patients. The epidemic was then at its height, and such was the demand for physicians, and the prevalence of the idea, that, as I came from the West Indies, I must be familiar with the yellow fever, that I soon became very extensively employed. Such, indeed, was soon the extent of my engagements, that I was compelled for a time to refuse my attendance on many patients, and to limit my visits from Race to Dock streets, and from the water to Third street.
From the first time I had an opportunity of seeing the yellow fever, I perceived that there existed but a very distant, if any, analogy between it and the fevers I had been in the habit of treating in the West Indies. And this opinion I have ever since entertained, in opposition to the statement of many respectable authorities; but in conjunction with some highly respectable physicians and friends, who, like myself, had had an opportunity of treating both diseases. The points of difference between these fevers will be noticed in a subsequent part of these observations. But although entertaining this sentiment, I very early came to the conclusion, that the yellow fever was the effect of a gastro-duodenic inflammation, somewhat modified by some unknown cause,—requiring the usual remedies for such a complaint, proportioned only to the strength of the patient, and the force of reaction in the system; and all my subsequent experience has only served to confirm me in this belief. Differing from many physicians respecting its bilious character, I have been led to believe, that the liver is very seldom implicated in the disease;—the secretion of bile, in the majority of cases, being very little, if at all altered. This may very readily be discovered by an attentive examination of the symptoms of the disease, as well as by the appearances noticed on dissection; the lining membrane of the stomach and duodenum presenting in almost every case, marks of inflammation, and giving passage to a large quantity of black matter, which I have always been led to regard as altered blood, mixed with mucus. The liver, on the contrary, so rarely showed marks of disease, that when it did, it was natural to regard its alteration as secondary.
Such being my opinion respecting the pathology of yellow fever, I cannot view otherwise than as secondary to the gastric affection, all the morbid conditions of other organs, indicated during life by their peculiar symptoms, and revealed on dissection by the ordinary marks of inflammation; such as affections of the lungs, kidneys, &c. This view of the subject will cease to be regarded as merely hypothetical, when it is recollected, that these symptoms and morbid appearances are occasionally not found; whilst the symptoms referrible to the gastric and duodenic irritation, being the true characteristics of the disease, are always present. Indeed, what would authorize us to regard any subject as affected with yellow fever, who would not present the pain in the stomach, the redness of the tip of the tongue, the thirst, irritability of the stomach, and vomiting either of simple mucus, or black matter? And, on the other hand, how many have died with these symptoms, who were not affected with all the others we have noticed, and, on dissection, have shown no mark of disease, except in the digestive apparatus? Finally, can pain in the head, affections of the kidneys, vomiting of bile, &c. constitute yellow fever, without the concurrence of some of the gastric symptoms we have enumerated?
With respect to the characteristic features of yellow fever, and the different signs, by which it may be distinguished from bilious fever, I must be very brief; as a great deal having been written on the subject, any long details in this place would occasion undue repetition of what is already known to the profession. A few words, however, may not be improper. Every one who has had frequent opportunities of seeing the yellow fever, must have noticed, among its most habitual signs, a peculiar inflamed glassy appearance of the eye, easily recognised, but difficult to describe. It is one, however, on which I should be willing to place considerable reliance, in establishing my diagnosis of this disease; as I do not recollect to have noticed it in any other form of febrile affection. Together with this, there is, in the majority of cases, an intense supra-orbitar pain, apparently unconnected with great disordered action of the brain, as the intellectual functions are generally unimpaired. These two signs, together with pain in the loins, and, in more advanced periods, the peculiar appearance of the skin, the vomiting of the coffee grounds matter, the intermission on the 4th day, the retention of muscular strength, and suppression of urine, are the only signs by which the yellow fever, so far as I am prepared to say, may be recognised. In regard to the supposed identity of this fever with the bilious, a great deal has been written; but I must confess, that I feel inclined to doubt the correctness of this opinion, for the following reasons:
1st. Bilious fever is almost always a remittent fever, presenting regular exacerbations, and, unless arrested by medical aid or some effort of nature, running its course, in a progressive manner, either to a happy or fatal termination; whereas the yellow fever is almost invariably a continued fever, presenting obscure and irregular, or even no remissions. On the fourth day, it generally presents so perfect a remission, as to cause the patient, in many cases, to imagine himself perfectly free from disease, and induce him to get up, and even sometimes to walk out. This remission, which sometimes amounts to an intermission, so far as an experience of upwards of forty years can authorize me to decide, is never found to attend in bilious fever, in which, if there be any remission, and recurrence of the unpleasant symptoms, the former is always a real convalescence, and the latter an accidental relapse.
2nd. The red colour of the eye, to which I have alluded above as occurring in the early stage of the yellow fever, and its peculiar yellow tinge in the after part of the disease, are different from the redness and yellowness of the same organ in bilious fever; in the first stage of which the eye presents a more fiery redness, and in the subsequent period, a more saffron yellowness.
3d. The colour of the skin in the two diseases presents also some difference, being more constantly noticed in yellow fever, and disappearing much more rapidly than in bilious fever. In yellow fever, moreover, it assumes, most commonly, a yellowish-brown or even mahogany tinge; whereas in bilious fever, when it occurs, it does not differ from the ordinary jaundice colour, of a lighter or deeper shade.
4th. These fevers may likewise be distinguished by an attention to the state of the intellectual faculties, and of the muscular strength; these remaining often unimpaired to the last in yellow fever, whereas, in a very large majority of cases of bilious fever, the mind becomes soon involved in the disorder of the system, and the greatest muscular debility prevails, even from the very onset of the attack.
5th. The matter vomited might of itself serve to distinguish the two diseases. Independently of the difference we shall notice when speaking of the black vomit, we may mention that patients complain, even sometimes from the commencement of the attack, of the acidity of the vomited matter; whereas in bilious fever, the mouth is bitter, and the matter ejected of the same taste.
6th. As a further mark of difference, we may state, that, in yellow fever, the tongue, except at the tip, the skin, and the pulse are sometimes little altered; whereas in bilious fever they are usually pretty much so.
7th. In respect to the duration of the two diseases, we may state as a general rule, that yellow fever runs its course to death or convalescence, in a much shorter time than bilious fever. Nor is the promptness of recovery from yellow fever less different from the slowness of convalescence, noticed in most cases of bilious fever.
8th. The suppression of urine is a frequent attendant on the last stage of yellow fever, and is seldom noticed in bilious fever.
9th. I have never witnessed a second attack of yellow fever in the same individual; whilst on the contrary, so far as I have seen, there is no limitation to the number of times a person may be affected with the other form of fever.
Prognosis.—As regards the prognosis in yellow fever, I shall merely state, that I generally found, an early evacuation from the alimentary canal, and a disposition to diaphoresis during the first twenty-four or thirty-six hours, and its continuance during the course of the disease, to be favourable omens. When the disease continued beyond the 7th, 9th, or 11th day, greater hopes might be entertained. It was likewise found, that the mortality was much smaller among patients, who remained free from apprehensions as to the nature and termination of the disease. To this cause, more than any other, do I refer my greater success among Quakers; who, being generally surrounded and comforted by their friends, retained more than any other class of people, the necessary tranquillity of mind.
Among the unfavourable signs may be mentioned, a discoloration of the skin before the fourth day. This symptom was, indeed, almost always a fatal one. Obstinate vomiting and costiveness, hæmorrhages from different parts of the body, unattended with an abatement of the symptoms, and vomiting of black matter, were very unfavourable; whilst a suppression of urine, agreeably to my experience, was always a fatal sign.
Black Vomit.—In a preceding part of these observations, in alluding to the black vomit, I took occasion to express my views respecting its nature,—stating that I regard it as consisting of mucous flakes, mixed with a large proportion of altered blood. That such is the true nature of this substance, on which so much has been said and written, I have had sufficient reason to be convinced. The opinion that it consists of altered bile, I deem totally untenable, for the following reasons: The matter is occasionally voided in large quantities, in cases in which the liver is not at all affected, and in which, after death, the gall bladder is discovered to be more or less filled with natural bile. Independently, of this, it may be stated, that the appearance of the two substances is very dissimilar;—the black bile vomited in bilious fever being of a homogeneous nature, and of a black or deep green colour; whilst the matter of the black vomit is, in a large majority of cases, a compound of a mucous, flaky substance, and a sanguineous matter, bearing some resemblance to the grounds of coffee, and, for the most part, of a brown tinge. When mixed with water, the two substances produce very different effects,—the bile mixing with and imparting a greenish tinge to it without difficulty, whilst the grounds of the other, float on the surface of the water, without mixing with and colouring it, in the same manner as bran, deprived of all its mucilage, or rather like mahogany saw-dust. This I consider as one of the best modes of distinguishing these two substances,—serving at the same time to establish a difference between the fevers, I was in the habit of observing in the West Indies, and the yellow fever of this country. Nor are these the only reasons for rejecting the supposition of the black vomit of yellow fever being of a bilious nature; for I have known this substance (and I suppose other practitioners have observed the same fact) occasionally to exude from surfaces, from which, in all probability, bile is excluded. I allude particularly to the skin and verous membranes. Thus it has often happened, that the application of a blister, especially in the advanced stage of the disease, has been followed by a copious exudation of a fluid, resembling, in all respects, the matter ejected from the stomach; an occurrence which was strikingly exemplified in a case, which fell under my immediate observation during the last visitation of the disease in this city, in 1820. During the same epidemic, I had occasion to attend a Mrs. H. about 70 years of age, who presented a curious example of the exudation of a similar substance from the peritoneum. She had not been exposed to the causes of the yellow fever, and indeed presented none of its ordinary pathognomonic signs. She was attacked very early in the morning with violent colic, attended with fever, great tenderness of the abdomen, and high colour of the face. She was bled at 10 o'clock; at 11 vomited a large quantity of coffee ground matter, and died in about 12 or 15 hours from the commencement of the attack. The next morning her body was examined in the presence of several highly respectable and experienced physicians, who all coincided in the opinion, that the matter vomited and which continued to be discharged from the nose, was identical with that discharged in yellow fever. The stomach as well as the intestines were found to contain a large quantity of a similar substance. The cavity of the peritoneum being likewise found filled with a large portion of it, we at first suspected the existence of an opening in the intestines, by which an effusion had taken place. After a careful and minute examination, however, no such opening was discovered. Our attention was now directed to the condition of the peritoneum itself, which was highly inflamed. It was, moreover, found, that the substance in question exuded from its surface,—the membrane, in many places, especially the portion of it which covers the liver, being coated so thickly with the grounds, that they could readily be scraped off with the back of a scalpel.
These cases show conclusively, that the matter of the black vomit, occurring in yellow fever, should not be regarded as altered bile; and that the supposition of its consisting of a secretion of the mucous membrane of the stomach, does not rest on a much more solid foundation. For bile can hardly be admitted to exude from the skin and serous membranes, and we cannot suppose, that fluids, similar in every respect, can be secreted from two surfaces, so very distinct in their organization, and in the nature of their ordinary products, as those of the mucous and serous membranes.
From these facts I am led to regard the black vomit as a true hæmorrhage, resulting from a state of previous irritation of the surface which furnishes it. That inflammation may be cause of it, we have a sufficient proof in the fact, that a similar fluid is occasionally vomited in cases of puerperal fever, when the irritation progresses from the serous to the mucous membrane of the intestines; as well as in cases of inflammation from blows on the stomach, and the action of poisons. A case of this kind, arising from a kick of a horse, was attended by myself and two respectable physicians in consultation, a few years ago; and another case arising from a large dose of carbonate of potassa, swallowed by mistake, occurred in my practice not long since. But as it would occupy too much time to give them here in detail, I pass them by without further notice.
That the matter of the black vomit is the product of a hæmorrhage, I have thought may also be inferred from the fact, often noticed by myself and others, of large portions of coagulated blood being found in the intestines; the surface having the appearance of the common black matter, whilst on cutting into them, the centre is found to consist of a red solid coagulum. I have also sometimes noticed, that the duodenum contained the coffee ground matter, and the intestines, coagulated blood. In such cases, in order to adopt the opinion of secretion, we must believe, that the same vessels, occupied in the secretory process, afforded, at the same time, passage to a portion of common blood; for we can hardly admit, that the mucous follicles are the organs secreting the black matter. Besides, is this not a mere dispute about words; and is it proved that what are called sanguineous secretions are not the result of the same action, which gives rise to hæmorrhagic exudations? and is there any other difference between the hæmorrhage of yellow fever, and of ordinary cases of hematemesis, than that arising from a difference in the quality of the blood?
Nor do I find much difficulty in believing, that the colour of the skin, which is more frequently brown than yellow, as well as the petechiæ, &c. are the effects of the stagnation of blood, altered by the capillaries of the surface, in the same manner as that exuding from the mucous surfaces. I believe that this opinion, suggested by some European writers, is supported by the fact, that this fluid exudes from the orifices made by the bites of leeches and the incisions of scarified cups; as well as from the raw surface occasioned by blisters; and that the vibices contain a serous fluid mixed with blood.
Analogy to Plague.—On comparing the symptoms of the yellow fever of this country with those of plague, as detailed so minutely and, I believe, accurately by authors, and especially by the physicians who accompanied Bonaparte to Egypt, I have been led to regard these diseases as bearing a closer analogy to each other than has hitherto been admitted. I do not pretend to assert that they are the same disease, but only that they are so nearly allied, as on some occasion, to lead even an experienced observer into an error of diagnosis. The great difference between them consists in the frequency of the affection of the lymphatic glands in the plague, and its comparative rareness in yellow fever; and in the greater predominance of gastric symptoms in the latter. Nevertheless, I have had, on many occasions, during our different epidemics, opportunities of noticing buboes, situated in the same parts as those mentioned by writers on the plague, running the same course, and curable by the same means. Carbuncles are frequently seen in both diseases, though not so frequently in yellow fever as in the plague. Both diseases present what are called the walking cases. Patients in both, though more frequently in yellow fever, retain their muscular strength as well as their intellectual faculties. So far as we are informed, the mortality in both is pretty nearly the same, and the treatment similar.
Contagion of Yellow Fever.—The question of the contagion or non-contagion of yellow fever has so long occupied the attention of the profession and been discussed so extensively, that I deem it unnecessary to devote much space to it here. Nevertheless, as I have had frequent opportunities of noticing the disease under all circumstances; in all parts of the city, and in the country; among the wealthy and the poor, I may without much impropriety offer, in a few words, the result of my observations and reflections on this head. I must unhesitatingly declare, that, establishing my opinion on what I have seen, I am led to the conviction, that the yellow fever is not a contagious disease; that it never has been carried hither in the way mentioned by contagionists; and that it has invariably proved an infectious disease, using this word to express a malady arising from a local source of contamination, other than a living body. It is plain, that this view of the subject does not exclude the possibility of a vessel carrying the disease to this or any other port; but, in that case, the vessel itself or its cargo, must be the source of infection, and not the individuals on board. And this may take place, when the port from whence the vessel sailed is free from the disease. That such has been the case, there cannot be any doubt; and that the idea, predicated on it, of the contagiousness of the fever is erroneous, I have not the least hesitation in believing.
How else than on the principle of infection, and not of contagion, can we explain the attack of individuals frequenting those parts of the city, where the disease had originated, and which (all the inhabitants having been removed to some distant situation) had been barricaded? How could we, in any other way, account for the exemption from the fever of individuals, who, out of the infected district, nursed, touched, and even slept with their diseased relatives and friends; and not always in clean and well ventilated apartments and parts of the city; but, in very many instances, in the filthiest hovels, and alleys, and among the lowest classes of society. Striking and unanswerable facts of the sort have frequently presented themselves to my observation, during our various epidemics. Children have sucked their parents, affected with the fever, and, in one case which fell under my notice, the child continued attached to the breast after its mother's death; and in all such instances with impunity. I have constantly reprobated the practice of burning the clothes and bedding of the dead, and have never found any bad results to occur to those who followed my advice. From a consideration of all these facts, I must once more express it as my decided opinion, that the yellow fever, so far as I have had an opportunity of observing it, is not a contagious disease.
Treatment.—Whatever opinion we may entertain respecting the specific nature of yellow fever, I was early convinced that this disease was not to be treated by specific remedies, and that our curative indications should be formed on an attentive consideration of the condition of the system in general, and of particular organs, as pointed out by the symptoms during life and the morbid lesions after death.
In a former part of these remarks, I suggested the opinion, that the yellow fever is a gastro-duodenic inflammation, (perhaps of a specific kind,) and that it required a mode of treatment appropriate to this morbid state; but proportioned to the strength of the patient, to the violence of the attack, and to the power of re-action. In general, however, I have not found active depletion by the lancet, as easily borne in this, as in bilious and other fevers;—the disease assuming more rapidly, under this plan, a state of prostration or adynamia. Nor can this appear surprising, since the same circumstance of a disease being of an inflammatory nature, but, under a peculiar condition of the system, contraindicating ample depletion, is a subject of frequent notice during certain epidemics; for example, of scarlatina, pneumonia, &c. With the exception of those cases, therefore, occurring in very robust and plethoric constitutions, and accompanied with much pain in the head, high febrile excitement, and hard pulse, either large or small, I have seldom resorted freely to the lancet. When, however, these symptoms presented themselves, especially the hardness of the pulse, I have not been sparing of blood-letting, and have sometimes repeated it several times with the most decided success. But even under these circumstances, I have seldom found that large bleedings were as beneficial as small and repeated ones;—the system not reacting always as energetically as could have been desired, and symptoms of prostration occurring with much more rapidity. I do not recollect to have bled with advantage, patients presenting a large, full, but compressible pulse, owing to the want of reaction; although the other symptoms might seem to indicate the propriety of the practice. The effect of bleeding on the vomiting was very different in this, from what I mentioned it to have been in the bilious fevers of the West Indies; owing probably to the circumstance, that, when, in yellow fever, the irritation of the stomach became sufficiently violent to give rise to this symptom, the state of the system was very often such as to contraindicate the use of the lancet.
The application of scarified and dry cups to the epigastrium and head, when there existed pain in these regions, was often resorted to, and afforded much relief. And I very much regret, that, during our epidemics, it was out of my power to make use of leeches to the former part, as so warmly recommended, at the present day, by the French and Spanish physicians; as I am inclined to the opinion, from the view I have adopted respecting the pathology of the disease, that, used early and in large numbers, they would prove very serviceable.
In conjunction with general and local bleeding, fomentations were had recourse to in almost every case, and applied to the epigastrium in the form of poultices, or flannels wrung out of warm emollient decoctions. In order to excite perspiration and to determine action to the surface, a tepid bath was occasionally prescribed, and in some cases afforded considerable relief; but as it was an inconvenient remedy, pediluvia, and hot bricks on which water, or water mixed with vinegar was poured, were substituted. In cases, however, in which much arterial action existed, these last means were not prescribed, until the pulse had been brought down by the lancet, and other remedies presently to be mentioned.
On the subject of emetics, I shall not enlarge; as I can safely assert, that I very seldom saw a patient recover from yellow fever, to whom tartarized antimony, or any other active remedy of the same class, had been administered. Of the impropriety and danger of this practice in the present disease, I was early convinced from a careful analysis of the symptoms, indicating an acute irritation of the stomach and upper portion of the small intestines, and from the circumstance, that, of the first family in which I was called to prescribe, five members, to whom emetics had been administered, had already fallen victims to the fever, under the care of a very respectable physician, and that three succeeding ones, who were treated agreeably to my view of the pathology of the disease, recovered. From these facts and reflections, I was induced to watch the effects of these remedies in subsequent cases, in my own practice, and in the practice of other physicians, and was soon led, from this extended experience, to abandon totally the use of tartar emetic in the treatment of this malady. Ipecacuanha in emetic doses was also tried by me; but although, thus administered, it did not occasion the bad effects resulting from the exhibition of the preceding article, yet it was often productive of harm, and never of benefit. These remarks, however, apply more particularly to the use of tartar emetic during the state of excitement of the fever, and not to that of collapse which sometimes precede it, and in which it is recommended by some physicians of the southern states. In this condition of the system, I have never resorted to it, and, I must confess, could not easily be persuaded to do so; suspecting that even in such cases, the digestive organs are already too far implicated, to justify the use of so powerful and acrid a remedy.
It would seem that the bad effects of emetics, and more particularly of tartarized antimony, resulted, not only from their irritating qualities, but also from the efforts of vomiting, during which the stomach is compressed by the abdominal muscles, and made to contract very forcibly. To this opinion I am naturally led from the circumstance, that purgatives, whose action is certainly primarily irritating, are very advantageously employed in yellow fever. It is not my intention to attempt here an explanation of this seeming contradiction. Leaving to others the accomplishment of this difficult task, I shall content myself with stating, that during the whole course of my long practice, I have seldom seen a patient die of this disease, whose bowels had been well evacuated, and in whom perspiration had been excited within the first twenty-four hours after the attack. I exhibited purgatives in almost every instance every day, until copious evacuations had been procured, and I generally found, that the mild purges were of greater service than those of a severe and irritating nature. Senna, acidulated with lemon juice or tamarinds, answered sometimes remarkably well, when the stomach could retain it. Castor oil, manna, salts, magnesia, were frequently employed by me with advantage; and although I did not make an extensive use of calomel in this disease, yet I prescribed it to children, and to adults, who, owing to great irritability of the stomach, could not retain other purgative medicines. When I resorted to it, I generally did so in doses sufficient to ensure a purgative effect, and never with a view of exciting ptyalism. In doing this, I was not guided, however, by any fear of the effects of a salivation, since I was well aware that a ptyalism occurring in malignant diseases is often a favourable crisis; but by a knowledge of the great difficulty experienced in producing it, and from the observation, that in cases in which it was obtained, much valuable time had been lost, and the patient might have recovered without.
To promote the operation of the above remedies, purgative enemata were resorted to, in the early stage of the fever; and were followed by the frequent use of injections, composed of emollient decoctions, from which the patient derived considerable relief and comfort.
As counter-irritants, blisters and sinapisms were used, and often with great advantage. They were found of much value when applied to the epigastric region, for the purpose of arresting the vomiting. Sinapisms were in general preferred to blisters, as being more prompt in their effects and more easily renewed. Blisters were sometimes applied to the extremities in the different stages of the disease; but so far as I can judge, from my experience, not with much real benefit.
I seldom derived much advantage from the use of tonics and stimuli in yellow fever; except when the powers of life seemed to fail, and petechiæ, vibices, hæmorrhages, and other signs of malignancy had occurred. In general, under such circumstances, the Peruvian bark, either alone or combined with serpentaria, was administered in preference to any other remedy of the same class. In cases, however, unattended with reaction, tonics and diffusible stimuli internally, and revulsives of all sorts externally, were had recourse to from the commencement of the attack, and sometimes with the desired effect of arousing the powers of the system. Opium was never found beneficial, on account of its tendency to aggravate or produce coma, as well as from its effect in suppressing intestinal evacuations.
Whilst making use of the above remedies, the plentiful exhibition of diluent drinks was not neglected,—care being taken, however, not to load unduly the stomach, and to select such drinks as would suit the taste of the patient. In almost every case, acids did not answer so well as the bland mucilaginous infusions. The drinks were almost universally allowed cold, except when there existed a tendency to perspiration; under which circumstances they were administered slightly warm and a little aromatic.
During the course of the yellow fever, some of the symptoms demanded particular attention. Influenced by the idea of prostration and dissolution, many practitioners, and myself for some time among the rest, resorted to the bark and other tonics for the purpose of arresting the black vomit, and of correcting that condition of the organs, which gave rise to this effusion; but after many unsuccessful trials, I was led to abandon this practice and to resort to other means. Of all the remedies employed to attain this effect, calcined magnesia mixed in a thick solution of gum arabic seemed to me to answer best; for whilst it succeeded, in many cases, in arresting the vomiting, it tended to keep the bowels open. Together with this, revulsive remedies were applied to the skin, and sometimes succeeded very well,—a sufficient proof, I think, that this hæmorrhage is the effect of an increased action of the mucous membrane of the digestive tube, and not of a passive condition of the capillaries of the parts. For the purpose of controlling the great irritability of the stomach, and arresting the vomiting occurring in the early stage of the disease, besides the usual remedies used in such cases, I found advantage in the use of small and frequently repeated injections with a solution of salts, an infusion of senna, or the like substances. Such a practice, however, did not seem to succeed so well in the latter stage of the disease.
With the intention of promoting the secretion of urine, in cases in which it was suppressed, all the diuretics, as well as every external stimuli, were in vain employed;—this symptom, as I have already mentioned, being, in all instances which fell under my immediate observation, the forerunner of death.
Article V.—Remarks on the Prophylactic Treatment of Cholera Infantum. By Joseph Parrish, M. D., one of the Surgeons to the Pennsylvania Hospital.
The great mortality of cholera infantum renders it one of the most interesting diseases, which come under the notice of the physician. Its ravages among the infant population of our large cities, are too well known, and too strongly felt, to require any comment. No disease contributes so largely to swell our bills of mortality during its prevalence; and were it not restricted to the summer season, it would prove a greater scourge to the community than consumption itself.
This mortality is owing less to our ignorance of the nature of the complaint, and the proper mode of treatment, than to the continued operation of the causes by which it is produced. I have often compared our endeavours to cure cholera infantum, while these causes remain, to an attempt to relieve inflammation in a part, while a thorn is sticking in the flesh. We may resort to bleeding and leeching; we may restrict our patient to the lowest diet, and the most perfect rest; we may employ all those remedies, which are ordinarily best calculated to reduce inflammation: but so long as the thorn continues in the wound, our efforts will be fruitless. Thus it is with cholera. We may obviate the more violent symptoms; we may procure temporary relief; we may even flatter ourselves that a cure has been effected: but the original causes have not lost their power; an increased susceptibility to their operation remains; relapse upon relapse is experienced; and at last the little sufferer, worn out by the successive attacks, sinks beyond the reach of medicine, and expires. Unhappily, the nature of the causes is such, that, in very many instances, their removal is exceedingly difficult, if not altogether impossible; and, under such circumstances, the patient who has once been severely affected, seldom recovers in the end. Hence it becomes of the greatest importance to prevent the occurrence of the disease; and attention to the prophylactic treatment is no less essential than the adoption of curative measures. It is with the view of calling the attention of the profession to this subject, that I have been induced to offer the following observations.
It is obvious, that, in the preventive treatment, two objects demand attention; first, to remove, as far as possible, the causes of the disease; and secondly, where their entire removal is not attainable, to fortify the system against their influence. On each of these, I shall offer a few observations.
I. Excessive and continued heat is, perhaps, the most fruitful source of cholera. Thus we find, that the disease makes its first appearance in the commencement of the hot weather, increases and becomes more fatal with the rise of the thermometer, and declines with the return of cool weather in autumn. During its continuance, it may be observed to vary with every permanent change of temperature. A few very hot days in succession, in the 6th month, are sufficient to call it into action; and during the height of its prevalence, a spell of cold weather will diminish, if not suppress it. In the summer of 1806, which was remarkably cool and pleasant, there was very little of the disease; and generally in moderate summers, it is much less prevalent than in those of a contrary character.
I believe that it is by a direct operation on the system, and not by the generation of miasmata, that heat proves so deleterious to the infant. In the country, where miasmata are most abundant, there is comparatively little cholera; for the heat of the sun is there moderated by the free circulation of the air; and the debilitating operation of the high temperature of the day is counteracted by the refreshing coolness of the morning and evening. It is in the close air of cities, that the complaint flourishes with greatest vigour; and the most confined situations are the most favourable to its production. Let any one take a walk, in a summer's morning, through the thickly built lanes and alleys of Philadelphia. He will be struck with the appearance of the children, reclining their heads, as if exhausted, upon the breast of their mothers, with a pale and languid countenance, a cool and clammy skin, a shrunk neck, and other signs of debility, arising from their confinement, during the night, to close and hot apartments. It will readily be believed, that such places are the very hot beds of cholera.
Heat, therefore, connected with confined air, being among the most frequent causes of the complaint, it is necessary, as far as possible, to counteract them. Should a strong predisposition to cholera be suspected, the best plan will be to send the child into the country during the summer. Both as a preventive and a remedy, country air is decidedly the most effectual, to which we can resort. But in most instances, it would be exceedingly inconvenient, sometimes impossible for mothers to leave their homes and occupations in the city; and, under such circumstances, it becomes necessary to substitute measures, which may produce, as nearly as possible, the same effects. To keep the child cool, and expose him to the fresh air, are the ends to be obtained. For this purpose, he should be carried frequently into the open squares, or beyond the suburbs of the city. I am in the habit of recommending to parents, whose circumstances will not allow of a removal from the city during the summer season, to make frequent excursions across the Delaware, and into the neighbouring woods of New Jersey. The refreshing effects of the air on the river are truly surprising. The brightened eye and animated countenance of the infant, give speedy proof of their favourable influence; and when labouring under the disease, even in its lowest stage, the little patient will often exhibit immediate signs of amendment.
In the prevention of cholera, much may also be expected from a proper attention to the lodging of children. Many parents have a great dread of the night air; and exclude it from their chambers, as sedulously as if it were infected with poison. But, in guarding their children from taking cold, they expose them to a much greater danger. Observe their mode of treatment. The doors and windows are carefully closed; the child is placed in a feather bed, with his parents on each side, and almost smothered with the bed-clothes. Perhaps other children are lodged in the same apartment; and thus the delicate system of the infant is exposed to the debilitating influence of great heat and stagnant air, combined with the effluvia, which, in such a situation, must be abundantly generated. Simply to enter such a room in the morning, is almost sufficient to sicken a healthy individual; how much more injurious must be its effects upon the lodgers themselves. Examine in the morning a child, who has passed the night thus confined. You will find him limber as a rag, exhausted by perspiration, wholly destitute of animation, without appetite, and on the very verge of cholera. I should recommend an entirely different plan of management. Instead of a feather bed, the child should be placed on a hard mattress, or on blankets folded and laid upon the floor. The covering should be light, but comfortable. The doors and windows should be open; so that fresh air, that pabulum vitæ, without which health cannot be sustained, may be freely admitted. Thus treated, instead of the feeble and sickly appearance before mentioned, he will present a lively countenance, with all that activity of motion, and enjoyment of existence, which are natural to his age, and afford the surest criterion of vigorous health. Experience has fully convinced me of the great importance of attention to the lodging of children, as a prophylactic measure; and this renders me desirous of impressing upon the profession generally, the truth of my own convictions on the subject.
With the same design of obviating the injurious effects of a high temperature upon the infantile system, I advise frequent ablutions with cool water, and its free employment as a beverage. Infants, unable to make their wants known, often suffer exceedingly from the inability of their attendants to understand them. During the heat of summer, the increased evaporation from their surface is necessarily productive of increased thirst, which, if unsatisfied, renders them uneasy and restless. To quiet them, the breast or bottle is offered. Aliment is thus given, where drink only was required; and the stomach, overloaded and oppressed, is apt to become irritable, and is thus brought into a condition most favourable to the occurrence of cholera. By attention to the peculiar language of infants, expressed not by words, but by signs, I have often been able to detect their wants; and, in many instances, have afforded the most decided relief, by simply giving them a little cool water for drink. From the dread which some individuals have for cool air and cold water, it would seem that they were considered rather as destructive poisons than as absolute necessaries. I have no fear of either, when judiciously employed; and as prophylactics in cholera, I do not think their place can be supplied.
But heat is not the only cause of this complaint. Dentition is well known both to predispose the system to its attack, and, after it has occurred, to increase its violence, and diminish the chances of recovery. In the employment, therefore, of preventive measures, it is highly necessary to attend to the state of the gums, and to remove or counteract this source of irritation. If at all swelled or painful, they should be lanced freely, and the operation should be repeated as often as their inflammatory condition may demand. In severe cases, much good may be expected from the application of blisters behind the ears. The irritation thus receives an external direction, and the stomach and bowels are in less danger of an attack. I was led to this practice, by observing that the eruption, which, during dentition, is apt to make its appearance behind the ears, often proves a most salutary effort of nature; and that, while it continues, the infant generally enjoys an exemption from those dangerous disorders, incident to this critical period of life. To imitate nature as closely as possible, the discharge from the blistered surface should be maintained for some time by stimulating dressings. I have witnessed the most beneficial effects from the practice, and can strongly recommend it to the attention of the profession.
II. At the same time that we endeavour to remove or diminish the causes of cholera, we should not neglect to put the system of the child in such a condition, as may enable it most effectually to resist their operation. As cholera is a disease of irritation, originating generally in a debilitated state of the alimentary canal, I believe this end may be most easily attained, by preserving the natural tone of the digestive organs. For this purpose, all flatulent and indigestible food should be carefully avoided. During the first year, the mother's milk is, in general, the most appropriate nutriment. When the stomach of the infant is very delicate, the diet of the mother should be strictly regulated; and, in all cases, it would be adviseable for her to avoid articles of a flatulent nature. While the child is still at the breast, if a predisposition to cholera be suspected, I would recommend the occasional use of nutritious animal juices. The sucking of small pieces of salt meat, as ham or dried beef for example, will sometimes be found productive of advantage. After weaning, animal food should always enter into the diet of the child. Many parents, fearing to render their children gross and unhealthy, restrict them altogether to vegetable aliments; and thus, by weakening the powers of digestion, prepare the way for that very result which they are most anxious to avoid.
With the same view of giving tone to the stomach, aromatics should be used habitually during the summer, in those cases, in which there is strong reason to apprehend the occurrence of cholera. While they produce a cordial impression on the stomach, and invigorate generally the digestive powers, they are liable to none of those objections which may be urged against the employment of the narcotic stimulants. Indeed, nature herself seems to have pointed them out as prophylactics against the diseases of hot weather. Our most powerful and valuable spices are the products of warm countries. Cinnamon, ginger, pepper, the clove, the nutmeg, are to be found only in tropical climates. In this arrangement, we see the hand of a beneficent Creator, who has provided, that, by the same high temperature, which renders the equatorial regions so fruitful of cholera, and other disorders of the bowels, the growth of those plants should be promoted, which are best calculated to invigorate the alimentary canal, and to fortify it against the inroads of disease. Facts are not wanting to prove the efficacy of spices in preventing intestinal complaints. We are informed by Dewar, in his treatise on the Diarrhœa and Dysentery, by which the British army in Egypt was attacked, that among the Mamalukes of that country, it was a universal practice, when they apprehended the approach of these disorders, to make use of cinnamon or ginger, with the almost uniform effect of averting them; and where the same practice was followed by the British soldiers, equal advantages were experienced. In the French army, so highly was the prophylactic power of the aromatics estimated, that every soldier was provided with a box of spices, which he was directed to use freely with his diet of fruit and melons.
When attending surgeon of the Alms-house hospital in this city, I had occasion frequently to prescribe in a syphilitic ward, which being situated directly under the roof, in a large garret, was liable, in the summer season, to become very much heated. As the patients were numerous, and the windows insufficient to admit of proper ventilation, the air became much contaminated; and the consequence was, that bowel complaints were very frequent and troublesome. I have often entered the ward on a summer's morning, and found almost every patient affected more or less with diarrhœa or cholera. It occurred to me, that the free use of some of the aromatics might be found serviceable in preventing the occurrence of these complaints. I accordingly directed, that every individual in the ward should drink a portion of strong ginger tea daily. I also ordered, that salt meat should be used twice in the week. By the steady pursuit of this plan, a very considerable change for the better was effected.
The employment of aromatics as prophylactics is not less beneficial in children than in adults. I would not, however, advise, that they should be given indiscriminately to all children, during the summer. It is only to those cases, in which a predisposition to cholera infantum exists, that I consider them peculiarly applicable; and here I believe they are capable of producing much good.
Before dismissing the subject of the paper, I will simply remark, in addition to what has been already said, that the occasional use of the cold bath, by the vigour it imparts to the system generally, and through it to the digestive organs, will often be found an excellent preservative against the summer complaint of children.
In this short account of the preventive treatment of cholera infantum, I have been less anxious to give a dissertation, embracing all that might be said on the subject, than to communicate those particular measures, which, according to my own experience, I have found most effectual. I will conclude the paper by the relation of a case, in which a strong predisposition to the disease was successfully counteracted. It will be proper, however, to premise, that the treatment of this case is by no means held out as an example to be generally followed with every infant, which may possibly become the subject of cholera. It is applicable in all its details only to those, in which, as in the present instance, there is every reason to apprehend, that the only alternative is between almost certain death, and the most careful prophylactic treatment.
Case.—A gentleman of this city, whose wife had arrived at a period of life, when she could not expect to be the mother of many more children, consulted me respecting an infant daughter, their only surviving child. I was informed, that they had already lost eight children, all of whom, with one exception, had died of cholera. It may readily be imagined, that every feeling of parental anxiety was awakened for their babe; and that no degree of attention on their part was considered too great, which might contribute to its preservation. It was placed under my care, not to be cured, but that I might, if possible, devise some plan of management which would avert the disease they had so much reason to apprehend. I felt the responsibility of the trust, and endeavoured to find it to the best of my ability. Every opportunity which I could desire was afforded me; for the infant, from its birth was submitted to my direction; and both the disposition and ability existed, on the part of the parents, to carry implicitly into effect every measure which I might recommend.
As the mother was unable to furnish sufficient nourishment, the first step was to provide a healthy wet-nurse, who might be willing to submit to the necessary regulations in respect to diet.
I believed the children of these parents to possess a constitutional weakness in the alimentary canal; and, on inquiry, I was told, that they had been kept upon a vapid diet, under the impression that it would contribute to their health. In the present case, therefore, the principal object was to communicate strength to the stomach and bowels. With this view, the child was accustomed, from an early period of infancy, to a generous diet. When very young, portions of ginger tea were given to it daily; and as soon as it was old enough to suck the juice of meat, it was encouraged to do so. The nurse, during the warm season, was kept upon a nutritious diet, consisting principally of animal food, with the occasional use of ginger tea; and every description of recent fruit and fresh vegetable food was forbidden. Under this management, the first summer was passed without any symptom of the disease; but I looked forward to the second with no little anxiety, when the child would have to struggle with the irritation arising from dentition.
The same plan was continued during the second summer, and still more rigidly enforced. The child was now old enough to take animal food freely in addition to the breast. It was allowed as much salt fish, ham, beef-steak, essence of beef, &c. as it desired; ginger tea was given daily; a little sound old port wine was occasionally directed; and both the child and the nurse were restricted from every species of flatulent and indigestible aliment. So anxious, indeed, were the parents, and so careful to carry my directions into full effect, that they allowed no forbidden article of food to enter the house, and denied themselves their wonted comforts, lest possibly their child might be injured.
The gums were carefully attended to, and lanced whenever the operation appeared to be requisite. All those measures, which I have before mentioned as serviceable in obviating the effects of great heat, so far as they were applicable to the case, were adopted. The second summer was spent wholly in the country.
Very little medicine was required, and none was administered, except of the mildest description. Frequently, when summoned to visit the babe, I have found the mother trembling with fear, and anxious that something might be done; and often, under such circumstances, have I begged it off from a dose of physic, having determined to avoid a resort to every thing of the kind, unless real necessity should demand it.
By a strict adherence to the plan above detailed, the period of dentition was passed in safety; and it is with heartfelt pleasure I can say, that no symptom of cholera afterwards made its appearance.
Article VI.—Case of Neuralgia cured by Acupuncturation. Communicated by J. Hunter Ewing, M. D.
The attention of the medical public having been of late much excited on the subject of acupuncturation, I am induced to communicate the following case.
For eighteen months, Miss —— had been afflicted, at intervals, with a severely painful affection of the nerves of the right cheek, immediately below the orbit of the eye, and extending to the angle of the lower jaw. On the 14th of January 1826, she was attacked more violently than usual, and the remedies, which had previously afforded some relief, now failed. Stimulating cataplasms, warm embrocations, laudanum, internally and externally, heat applied externally to the cheek by means of very hot flannels, produced not the slightest mitigation of the pain; and she continued to suffer excessively until the afternoon of the 15th; when acupuncturation being proposed, she consented to the operation with this remark,—"any thing to relieve me from this agony."
The needles were immediately procured, and three inserted about an inch from each other. Two in a line parallel with the inferior edge of the orbit of the eye, and half an inch below it; and a third below, and equidistant from the others. The first two were introduced to the depth of three-fourths of an inch; the last, a full inch. They were inserted very gradually and with a rotary motion.
The second needle was scarcely introduced, before the patient exclaimed, "the pain has entirely left me." When the third was introduced, she experienced a stiffness in the muscles of the cheek, and a creeping sensation, as if a spider's web had been drawn across the face; but no painful sensation whatever.
Such was the exhausted state of her system from the excessive pain she had suffered, that when thus relieved, she requested a pillow to rest her head on, and fell into a gentle slumber.
About two hours after the insertion of the needles, I again visited my patient, and found her still perfectly free from pain, and seated at a table reading. She thanked me for the relief I had been the means of affording her, and requested me not to withdraw the needles, lest the pain might return. Upon being apprised of the risk that might attend their being allowed to remain, she observed, that she would rather have a servant to watch her whilst she slept. The propriety of their removal being further urged, she at last consented. There was no return of pain.
The next morning, the patient remarked, that the stiffness of the cheek, and a numbness of the whole right side, continued through the night; and though she did not sleep very soundly, she was free from pain and rested well.
By the third day, the stiffness and numbness had passed away, and there was no return of pain. Several weeks have now passed, and she has had no relapse; although often since exposed to causes, which, heretofore, had always excited violent attacks. Previous to the operation, she seldom passed as many days without severe suffering.
Although I have performed this operation many times, and been present when others have performed it, I have never seen a case, in which its efficacy was so decided, or in which the relief afforded was more unquestionably attributable to the action of the needles.