Hunger Not Due To Emptiness of the Stomach

Among the suggestions which have been offered to account for a peripheral origin of the sensation is that of attributing it to emptiness of the stomach. By use of the stomach tube Nicolai[19] found that when his subjects had their first intimation of hunger the stomach was quite empty. But, in other instances, after lavage of the stomach, the sensation did not appear for intervals varying between one and a half and three and a half hours. During these intervals the stomach must have been empty, and yet no sensation was experienced. The same testimony was given long before by Beaumont,[20] who, from his observations on Alexis St. Martin, declared that hunger arises some time after the stomach is normally evacuated. Mere emptiness of the organ, therefore, does not explain the phenomenon.