Incubation Period.
An accurate determination of the period of incubation in influenza presents great difficulties. The large number of cases with the consequent multiple opportunities for infection in the case of every individual add to the difficulty. Under any circumstances the period is very short. Parkes, many years before the 1889 epidemic, believed that an incubative period sometimes exists; that it was sometimes very short and sometimes of many days duration.
“In the Transactions of the College of Physicians it is stated that in the epidemic of 1782, seventeen persons came to London to an hotel, and on the following day three were attacked with influenza. Haygarth says that a gentleman came to Chester from London, on the 24th of May, 1782, ill of influenza; a lady, into whose family he came, was seized on the 26th, and was the first case in the town. Haygarth states, evidently with the view to point out the possibility of a direct contagion, that the gentleman was engaged to be, and was afterwards, married to this lady. In this case the longest possible incubative period was two days. In 1782 a family landed at Harwich, from Portugal, and came to London directly; the day after their arrival the lady, two servants and two children were all seized. Two men-of-war arrived at Gravesend from the West Indies; three Custom-house officers went on board; a few hours afterwards the crews of both vessels were attacked. Some other cases are on record where the incubative period, if it existed, could not have been more than a single day. On the other hand, some cases are on record in which the incubative period must have been two or three weeks.”
Leichtenstern believed that the usual incubation period is from one to three days although some cases have been reported in which it is without doubt no longer than twelve hours. Parsons in reporting for England also gives the incubation period as from one to three days as a rule.
It is reported in France in 1918 that in one institution thirty-one cases out of thirty-three individuals occurred within three days, all of them infected by one nurse.
MacDonald and Lyth report in the British Medical Journal for November, 1918, an interesting observation concerning the incubation period in influenza. These two individuals were traveling from London to York in the same compartment with an individual who was just convalescing from influenza. Exactly forty-one hours after being on the train with this individual, they both came down with the disease. One suffered lightly while the other was severely ill. The wife and two children of the latter contracted the disease in turn, and with them also the first symptoms appeared suddenly after a delay of about forty-eight hours.
Stanley, in studying the epidemics of influenza in San Quentin Prison, found that as a rule there was an increase in incidence following the Sunday picture shows. This usually occurred on Tuesdays and Wednesdays, giving an apparent incubation period of from thirty-six to sixty hours. He tabulated the records of twenty-nine individuals who had presumably become exposed at the show and found that the incubation period averaged about forty-eight hours.
The majority of observers give the incubation period as from twenty-four hours to four or five days, most often two or three days.