Synthesis of 2-methyl-4-selenoquinazolone, 2-phenylbenzoselenazole, and its derivatives / Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Faculty of Pure Science of Columbia University

by Yü-Gwan Chen

Monacetyl Derivative

Five grams of the monoamino selenazole were heated on a water-bath with 10 cc. of acetic anhydride until the solution was clear, which took about two hours. 100 cc. of water were poured into the mixture, which was then neutralized with dilute ammonium hydroxide. The precipitate was filtered, decolorized by animal charcoal, and recrystallized from dilute alcohol.

The acetyl compound, 6-acetamino-2-phenylbenzoselenazole, forms colorless crystals, melting at 188.1°-.7°C. (corr.). It is insoluble in ether, benzene, carbon disulphide; slightly soluble in toluene; soluble in alcohol, ethyl acetate, amyl acetate, acetone, and acetic acid. A pure sample was analyzed and gave the following result,

	Calculated for C15H12N2SeO	Found
Nitrogen	8.88%	8.92%	8.68%