At 9.30 a.m. on October 26th, 1848, the mission left Coomassie on its return journey to the coast, and arrived at Cape Coast Castle on November 4th. This was the first occasion on which a British Governor, or a body of regular troops, had ever visited Coomassie.

In March, 1849, a further change took place in the distribution of the regiment in the West Indies, No. 7 Company, under Captain R. Hughes, proceeding to Nassau from Jamaica. There were thus the head-quarters and 3 companies in Jamaica, 3 in Nassau, 2 in Honduras, and 2 in West Africa.

In June, 1849; the Acting Governor of Sierra Leone found that the state of affairs in Sherbro, a low-lying tract of country some seventy-five miles to the southward of Sierra Leone, imperatively called upon the British to take steps for putting an end to the war which for a long time had been carried on between the rival chiefs of the Caulker family, and had utterly paralysed trade. H.M.S. Alert and Adelaide were to be employed, but as a military force was required to proceed with the naval one, the under-mentioned force embarked in the Colonial steamer Pluto on the 18th of June: Captain Grange, Lieutenant Jones, and 45 men of the 1st West India Regiment, and 44 men of the 3rd West India Regiment. The expedition arrived at Yawrey Bay, at the mouth of the Cockboro River, on the 19th of June, when a stockaded fort was shelled and destroyed by the Adelaide. The expedition then proceeded to Bendoo, and after some delay, owing to the difficulty in inducing the chiefs to come in, returned to Yawrey Bay on the 29th, where negotiations were held and a treaty of peace between the Government and rival chiefs signed. The detachments rejoined at Freetown, Sierra Leone, on July 7th.

On the 29th of November, 1849, Lieutenant Tunstall and 34 men of No. 2 Company of the 1st West India Regiment, left Cape Coast Castle and proceeded to Appollonia in canoes, in aid of the civil power. After an absence of three weeks, during which they endured great hardships from exposure and fatigue, they rejoined their detachment at Cape Coast.

In the beginning of the year 1850, the Rio Nunez was in such a disturbed state as to necessitate the Governor of Sierra Leone taking steps for the protection of British subjects there. Some influential chiefs of the river having also besought the intervention of the Government to restore peace, commissioners were appointed, and as war was actually being carried on at the time, a military force was detailed to accompany them. This force consisted of Lieutenant Searle and 33 men of the 1st West India Regiment and Captain Prendergast and 34 men of the 3rd West India Regiment, and it embarked in H.M.S. Teazer on the 22nd of February, 1850. The Teazer arrived at the Rio Nunez on the 24th, and proceeded up the river to Ropass, a town some distance up the stream, where the commissioners landed with the escort. A "palaver" was held at this place on March 1st, the rival chieftains being attended by large bodies of armed men, but no satisfactory arrangement was arrived at, and next day the commissioners and troops proceeded to Walkariah, a town higher up the river. Here matters were finally amicably settled, and the party returned to Sierra Leone on March 9th.

In the West Indies there had been little change since 1849, except that on the 13th of February, 1851, the head-quarters and two companies were removed from Up Park Camp to Spanish Town; and a detachment consisting of half a company, under Ensign Cave, was sent to Turk's Island in December, 1851. This latter rejoined head-quarters in Jamaica in January, 1852; and in February, No. 1 and No. 4 Companies, under Captain Robeson, rejoined from Honduras. In the same year, however, they again went on detachment: No. 1, under Captain Grange, to St. Christopher's, and No. 4, under Lieutenant Imes, to Barbados. The distribution of the regiment in September, 1852, was thus: the Grenadier, No. 3 and No. 6 Companies, at Jamaica; the Light, No. 7 and No. 8 Companies, at Nassau, No. 4 at St. Christopher's, No. 1 at Barbados, No. 5 at Sierra Leone, and No. 2 at Cape Coast Castle.

In February, 1852, Major L. Smyth O'Connor, 1st West India Regiment, had arrived at Sierra Leone and assumed command of the troops in West Africa, and finding in May that the company on the Gold Coast was reduced by deaths to only 50 rank and file, he recommended that it should be recalled to Sierra Leone, the Gold Coast Corps, then almost completed, being quite sufficient for the garrison of the Gold Coast.

In September, 1852, Major O'Connor was appointed Governor of the Gambia, and as by Horse Guards letter of September 20th, 1852, "it was considered expedient that he should continue invested with the command of the troops on the West Coast of Africa, and move the head-quarters to the Gambia," this was done in October, 1852.

The War Office having approved of Major O'Connor's recommendation, No. 2 Company, 50 strong, arrived at Sierra Leone from Cape Coast Castle on March 20th, 1853.