Ὄπιον,
Opium, is treated of under [poppy].
Commentary. Although we treated of the deleterious effects of opium on the animal economy in the [Fifth Book], and have given a general description of the medicinal properties of the poppy in the proper place, we shall avail ourselves of the present opportunity to supply some important information regarding the ancient use of opium in the practice of medicine. Though mention is made of “the juice of the poppy,” and of “meconium” as soporifics in the works of the Hippocratists (De Mulieribus, ii), it does not appear that these articles were much in use until a later age. “The juice of the poppy” is noticed likewise by Theophrastus (Fr. 20, 35), and the process of gathering this juice is briefly alluded to by him (H. P. ix, 8, 2); but the nature of his work did not lead him to say anything of its medicinal uses. There can be no question, we presume, that the “papaveris lacryma” of Celsus was opium, i. e. the concrete juice of the poppy. He prescribes it on many occasions, both externally and internally. For example, as an ingredient along with hyoscyamus, burnt lead, and other ingredients for an emollient plaster to be applied in arthritic pains (v, 18, 29, 35), and as an injection with alum, acacia, and henbane in earache (vi, 7); as an ingredient in various collyria for complaints of the eyes (vi, 6); as an injection in complaints about the anus (vi, 18), and in many other cases. The famous Methodist, Cælius Aurelianus, is very guarded in his use of opiates, and he appears to approve of the opinion of those who held that poppy does not induce sleep, but oppression of the senses; “papavera autem pressuram non somnum faciunt.” (i, 1.) See also Pass. Tard. (i, 5.) Dioscorides, then, is the first authority that gives a detailed account of opium and its uses in medicine. Treating of the cultivated poppy, he says, that its juice is very congealing, incrassative, and desiccative, when taken in small quantity, to the size of a vetch, is anodyne, soporific, concoctive, and is useful in coughs and cæliac affections. Taken in greater quantity, it proves injurious, inducing lethargy and death; it is beneficial in headache when rubbed in with rose oil; and in earache when injected with almond oil, saffron, and myrrh; in inflammations of the eyes with the roasted yelk of an egg and saffron; and for erysipelas and wounds with vinegar; for gout with a woman’s milk and saffron; and when applied as a suppository per anum it induces sleep. The best kind is that which is dense, has a heavy stupefying smell, is bitter to the taste, readily incorporating with water, smooth, white, not rough, nor grumous, nor moulding like wax in the process of straining; when laid in the sun softening, and when applied to a lamp not burning with a smoky flame, and after being extinguished preserving its powers in its smell. He then mentions several modes of adulterating it which were practised in his time, and then adds, it is roasted for ophthalmic medicines upon a recent shell until it becomes soft and of a tawny colour. Erasistratus says that Diagoras condemned the use of it in diseases of the ears and eyes, as inducing dimness of sight and coma. And Andreas says, that if it had not been adulterated those that rubbed it in would have been deprived of sight by it. But Mnesidemus says, that the only proper use of it is by the smell, as thus disposing to sleep, for that otherwise it proved injurious; but these statements are false, as is proved by experience; for the operation of the medicine is attested by its effects. He concludes by describing the modes by which opium and meconium were prepared, but it will be sufficient for our purpose to state that his description of the former of these is exactly the same as the method now commonly practised. See Kæmpfer (Amæn. Exost. 643), and Pereira (M. M. 1274.) The meconium was the expressed juice of the leaves and head, and is not now in use. Dioscorides states that it is much weaker than the other. (iv, 65.) Pliny’s description of the opium and meconium is obviously taken from Dioscorides, or both these authors must have copied from some preceding authority. He thus describes the meconium: “cum capita ipsa et folia decoquuntur, succus meconium vocatur, multum opio ignavior.” (H. N. xx, 76.) Opium it is certain was freely used by the Empirics, and accordingly it will be found that it is a very common ingredient in the prescriptions of Scribonius Largus, and Marcellus the Empiric. The latter gives several formulæ for collyria, in which opium occurs, and he is at pains to state that it is the concrete and not the expressed juice which must be used. (De Medicamentis, viii.) He also prescribes it internally for pains of the kidneys (xxvi), as an enema in colic (xxix), and in many other cases. Galen would appear to have had very sound opinions respecting the use of opium in the treatment of diseases. He professes, indeed, never to have had recourse to it when he could help it. (De Comp. med. sec. loc. iii); but yet he prescribes it in cæliac and certain stomach affections (ibid, viii), and even in intense pains of the eyes (Meth. Med. ii), although in general he condemns the application of it in collyria. (Meth. Med. iii; and De Comp. m. s. l. ii.) He often mentions that castor counteracts the prejudicial effects of opium. (De med. sec. loc. iii, and viii.) Of all kinds of opium he pronounces the Theban to be the best. (De Antid. i.) Avicenna, besides treating of opium as a poison, and giving the general properties of poppy, under that head, has a very interesting chapter on opium in his Mat. Med. He defines opium to be the juice of the black Egyptian poppy dried in the sun. He says it proves fatal if given in a larger dose than two drachms; but the proper dose he states to be the size of a tare. He states in parenthesis that opium is also formed from the juice of the wild lettuce (lactucarium?). He calls it narcotic and sedative of all pains, whether taken internally or rubbed in. It is useful, he says, in apostemes, especially in those of an inflammatory nature. He says of it, that it dries up ulcers; with the yelk of an egg forms a liniment for gout; it proves soporific if a cloth smeared with it be placed below the head; allays pain if injected into the ear affected, along with myrrh and saffron; allays chronic pains of the head, and sometimes cures them; soothes the pains of ophthalmy, and the apostemes of the eyes, with the milk of a woman; but yet he adds, that many of the ancient authorities had condemned the use of it in such cases as proving injurious to the sight; it allays incessant coughs, and often cures that kind which is noisy; improves the stomach in peculiar cases, when debilitated by excess of heat and humidity, is braced by it; but in many constitutions, opium, so administered, impairs digestion; it stops diarrhœa; is useful in dysentery, and in ulcerations of the intestines. It proves fatal, he says, by congealing the vital powers and extinguishing the innate heat; and its antidote is castor. He concludes by saying, that three times the amount of the seed of hyoscyamus, or double of the seed of mandragora, may be given as a substitute for it. (ii, 2, 519.) Haly Abbas treats of opium more briefly, stating in general terms that it is a soporific and sedative medicine. He seems to say that from half a drachm to a drachm will prove fatal. (Pract. ii, 40, 318.) Serapion’s account of opium is mostly made up of extracts from Dioscorides and Galen, with a few brief notices of the opinions held by Arabian authorities, which do not contain anything of much interest. (c. 374.) Rhases’s chapter upon the poppy contains many extracts from the Greek authorities on opium, with a few from Arabian writers, which, however, contain nothing of much interest after what we have given from Dioscorides and Avicenna. Like Serapion, he says, from half a scruple to a scruple is a dose, and that two drachms will prove fatal. His authority, Mesue, says it forms semen. Another of them, Joannitius, seems to say that it binds the bowels in general, but yet has some laxative power. (Cont. l. ult. i, 533.) In the ‘Book of Experience,’ as quoted by Ebn Baithar, poppy-juice is recommended in complaints of the eyes, and in pains of the head when applied to the forehead. One of his Arabian authorities mentions its good effects in diarrhœa; and it is also spoken favorably of as an application to burns. Ebn Baithar’s account of this article is otherwise mostly made up from Dioscorides.
Ὀπὸς,
Succus Cyrenaicus, Medicus, and Syriacus, are so named per excellentiam, being considerably hot and flatulent. The Cyrenaic is hotter and more attenuate than any of the others.
Commentary. The high interest which attaches to these articles might well dispose us to wake our classical recollections, in order to illustrate the nature of them, if the narrow limits to which we feel that we are restricted did not restrain us from such an undertaking. We beg, however, to quote the words of one of our ablest authorities in illustration of this subject. Dr. Lindley, treating of the plants which yield assafœtida, says, “assafœtida is the milky juice of various species of Ferula inhabiting Persia and neighbouring countries. Of these, F. assafœtida is the plant described by Kæmpfer. (Amæn. Exot. 535); but F. Perscia and others, are no doubt also the origin of this drug. The Asa dulcis or Laser Cyrenaicum was yielded by a Thapsia, and probably Thapsia Garganica. This drug was in high reputation among the ancients for its medicinal uses; it had miraculous powers assigned to it—power to neutralize the effect of poison, to cure envenomed wounds, to restore sight to the blind, and youth to the aged; these were only a part of its reputed properties; it was also reckoned antispasmodic, deobstruent, diuretic, &c., &c. So great was its reputation, that the princes of Cyrene caused it to be struck on the reverse of their coins; and the Cyrenean doctors were reckoned among the most eminent in the world.” (Veg. King. 776.) See further Pereira (Mat. Med. 1041), and most especially Sprengel in Dioscor. (iii, 85.) From what we have stated, our readers will readily comprehend that the Median and Syrian juices were varieties of the gum resin of Ferula assafœtida; while the Cyrenean juice was the gum resin of a congener, namely (as stated above), the Thapsia Garganica, called silphium by the ancients. That the Cyrenaic juice was the product of the silphium, is positively stated by Strabo. (Geogr. xvii, 3.) We shall reserve what we have to say on its medicinal properties till we come to that article. It is the laser and laserpitium of the Roman authors. It occurs in the Hippocratic collection. (De Morb. iv.) By the Arabian authors it is generally treated of under the name of Assa, and hence its modern appellation.
Ὀρίγανος,
Origanum, Origany, or Wild Marjoram; all the species of it are possessed of incisive, attenuant, desiccative, and calefacient powers in the third degree.
Commentary. Apuleius enumerates three species and recommends them for coughs. (c. 122.) Galen and Dioscorides also describe the same number of species, which may be referred—the 1st, to the Origanum Heracleoticum, L.; the 2d, to the O. onitis; and the 3d, to O. sylvestre album. Dioscorides describes the particular uses of these plants so fully that we cannot find room for his separate articles on each. Suffice it to say, that he sets down the first as being laxative, emmenagogue, and expectorant. (iii, 29, 30, 31.) Galen, like our author, merely states the properties of the Origana in general terms. The Arabians call the origanum diuretic and vermifuge. They copy, as usual, from the Greeks. See Serapion (c. 310), Avicenna (ii, 2, 526), and Rhases (Cont. l. ult. i, 125.) The Origanum Smyrnæum occurs in the modern Greek Pharmacopœia (121.)