Dr. Fleming's essay was undoubtedly of great utility in calling attention to the abuses pertaining to Continental physiological teaching. That which makes his essay of chief value is not so much the presentation of arguments, as the long array of unquestionable facts for which the authorities are given. There is hardly a physiological writer of distinction from whose works he did not quote to illustrate the excesses he condemns.
It is Dr. Markham's essay, however, which for us, at the present moment, has principal significance. It is the argument of a professional physiologist, defending the right of scientific research within limits which then seemed just and right to the entire medical profession of the United Kingdom. Every physiologist or physician upon that committee which examined the essays is said to have marked with approval this presentation of their views; and Professor Owen— probably then the most distinguished man of science in Great Britain— appended a note significant of his especial agreement. And yet Dr. Markham's essay is never quoted at present by any advocate of free vivisection; even Professor Bowditch in that address to which reference has been made left unmentioned the work of his professional brother, one of the earliest defenders of animal experimentation.
The reader of Dr. Markham's essay will not find it difficult to comprehend the cause of this significant silence. Although the essay was in no way sympathetic with antivivisection, it represented the Anglo-Saxon ideal, in marked distinction from the doctrines which then prevailed in the laboratories of Continental Europe, and which since have become dominant throughout the United States. Defending the practice of vivisection as a scientific method, Dr. Markham freely admitted the prevalence of abuses to which it was liable when carried on without regulation or restraint. Under proper limitations it was at present necessary that some vivisection should be allowed; but with the advance of knowledge, he believed that this necessity would decrease, and the practice of animal experimentation gradually tend to disappear. Some quotations from this essay will be of interest.
"The proper and only object of all justifiable experiments on animals is to determine unknown facts in physiology, pathology, and therapeutics, whereby medical science may be directly or indirectly advanced. When, therefore, any fact of this kind has been once determined and positively acquired to science, all repetition of experiments for its further demonstration are unnecessary, and therefore unjustifiable.
"All experiments, therefore, performed before students, in classes or otherwise, for the purpose of demonstrating known facts in physiology or therapeutics, are unjustifiable. And they are especially unjustifiable because they are performed before those who, being mere students, are incapable of fully comprehending their value and meaning. THEY ARE NEEDLESS AND CRUEL: needless, because they demonstrate what is already acquired to science; and especially cruel, because if admitted as a recognized part of students' instruction, THEIR CONSTANT AND CONTINUED REPETITION, THROUGH ALL TIME, WOULD BE REQUIRED. I need hardly say that courses of experimental physiology are nowhere given in this country, and that these remarks apply only to those schools i France and elsewhere where demonstrations of this kind are delivered."[1]
[1] "Experiments and Surgical Operations on Living Animals: One of Two Prize Essays." London: Robert Hardwick, 1866.
"ESPECIALLY CRUEL!" Little could Dr. Markham have imagined that this "especial cruelty" which he thus so emphatically denounced in 1864 would spread from the Continent of Europe and become, within the short space of a single generation, the accepted method of physiological instruction in every leading college or university in the United States!
Dr. Markham evidently fancied that with the larger acquirement of facts the vivisection method would gradually become obsolete. He says:
"A consideration of the conditions here proposed as requisite for the rightful performance of experiments on living animals shows that experiments of this kind must ever be very limited, because those persons who are fitted for the due performance of them are of necessity few in number; and that in proportion as new facts are added by them to our knowledge, THE EXPERIMENTS MUST DIMINISH IN NUMBER…."
"Thus, then, we have seen that in the case of experiments legitimately performed on living animals, … such experiments must always, from their nature, be comparatively few; that they must gradually diminish with the advance of scientific knowledge, so that A TIME MAY COME WHEN EXPERIMENTS ON LIVING ANIMALS WILL CEASE TO BE JUSTIFIABLE.