[624] H. Stillmark, Dorp. Arb., Bd. iii., 1889.
[625] Kobert’s Lehrbuch, 453-456.
It is essentially a blood poison, coagulating the blood.
The blood, if carefully freed from all fibrin, is yet again brought to coagulation by a small amount of this body.
If castor-oil seeds are eaten, a portion of the poison is destroyed by the digestive processes; a part is not thus destroyed, but is absorbed, and produces in the blood-vessels its coagulating property. Where this takes place, ulcers naturally form, because isolated small areas are deprived of their blood supply. These areas thus becoming dead, may be digested by the gastric or intestinal fluids, and thus, weeks after, death may be produced. The symptoms noted are nausea, vomiting, colic, diarrhœa, tenesmus, thirst, hot skin, frequent pulse, sweats, headache, jaundice, and death in convulsions or from exhaustion. Animals may be made immune by feeding them carefully with small doses, gradually increased.
The post-mortem appearances are ulceration in the stomach and intestines. In animals the appearances of hæmorrhagic gastro-enteritis, with diffuse nephritis, hæmorrhages in the mesentery and so forth have been found.
§ 615. Toxalbumin of Abrus.—A toxalbumin is found in the Abrus precatorius (Jequirity) which causes quite similar effects and symptoms. That it is not identical is proved by the fact that, though animals may become immune by repeated doses of Jequirity against “Abrin,” the similar substance from castor-oil seeds only confers immunity against the toxalbumin of those seeds, and not against abrin; and similarly abrin confers no immunity against the castor albumin. Either of these substances applied to the conjunctiva produces coagulation in the vessels and a secondary inflammation, to which in the case of jequirity has been given the name of “jequirity-ophthalmia.”[626]