[721] Edin. Med. Journ., April 1865; Brit. and For. Med. Chir. Journ., Oct. 1865.
§ 723. Manner of Introduction of Arsenic.—Arsenious acid exerts a poisonous action, whether it is taken by the stomach, or introduced into the system by any other channel whatever. The differences in the symptoms produced by external application (as through a wound), and by swallowing arsenious acid in substance or in solution, are not so marked as might be expected. It was probably Hunter who first distinctly recognised the fact that arsenic, even when introduced outwardly by application to an abraded surface, exerts a specific effect on the mucous membrane of the stomach. Brodie[722] states, “Mr. Home informed me that in an experiment made by Mr. Hunter himself, in which arsenic was applied to a wound in a dog, the animal died in twenty-four hours, and the stomach was found to be considerably inflamed. I repeated this experiment several times, taking the precaution of always applying a bandage to prevent the animal licking the wound. The result was that the inflammation of the stomach was commonly more violent and more immediate than when the poison was administered internally, and that it preceded in appearance the inflammation of the wound.”
[722] Phil. Trans., 1812.
§ 724. Cases of Poisoning by the External Application of Arsenic.—A mass-poisoning by the external use of arsenical violet powder to infants occurred in England some years ago. Two deaths from this cause were established by coroners’ inquests.[723] Dr. Tidy found the violet powders used in the two cases to have the following composition:—
[723] “Gleanings in Toxicology,” by C. Meymott Tidy, M.B.—Lancet, Aug. 21, 1878.