Theobromin.
Caffein.
and experiment has shown that theobromin is weaker than xanthin, and caffein still weaker than theobromin.
Loew[39] makes the following generalisations:—
[39] Ein natürliches System der Gift-Wirkungen, München, 1893.
1. Entrance of the carboxyl or sulpho groups weakens toxic action.
2. Entrance of a chlorine atom exalts the toxic character of the catalytic poisons (Loew’s catalytic poisons are alcohols, ether, chloroform, chloral, carbon tetrachloride, methylal, carbon disulphide and volatile hydrocarbons).