2. White matter—(a) from cerebrum; (b) from cerebellum.
3. Kephalin—(a) from cerebrum; (b) from cerebellum.
4. Ether extract, kephalin-free—(a) from cerebrum; (b) from cerebellum.
5. Substances soluble in cold alcohol—(a) from cerebrum; (b) from cerebellum.
6. The albuminoid residue—(a) from cerebrum; (b) from cerebellum.
The general results were as follows:—
| Cerebrum, 460·8 grms. Mgrms. of PbSO4. | Cerebellum, 156·2 grms. Mgrms. of PbSO4 | |
|---|---|---|
| White matter freed from kephalin by ether, | 0·0 | 5·0 |
| Kephalin, | 1·5 | 6·0 |
| Ether extract, kephalin-free, | 0·0 | 0·0 |
| Substances soluble in cold alcohol, | 0·0 | 0·0 |
| Albuminoid residue, | 40·0 | 6·0 |
| 41·5 | 17·0 |
The aqueous extract contained 1·5 mgrm. of lead sulphate. In neither of the cases did the pathologist ascertain the total weight of the brain, but, presuming that the weight was an average weight, and that the lead in the remainder of the brain was similarly distributed, the amount of lead calculated as sulphate would amount to 117 mgrms. From these results it appears to the author probable that lead forms a substitution compound with some of the organic brain matters. This view would explain the absence of changes apparent to the eye found in so many of the fatal cases of lead encephalopathy.
§ 785. Lead taken for a long time causes the blood to be impregnated with uric acid. In 136 cases of undoubted gout, 18 per cent. of the patients were found to follow lead occupations, and presented signs of lead impregnation.[850]