Face to face with danger, the duke had found his old strength: and he was the first to rush upon his enemies, loudly challenging Orsino in the hope of killing him should they meet; but either Orsino did not hear him or dared not fight; and after an exciting contest, Caesar, who was numerically two-thirds weaker than his enemy, saw his cavalry cut to pieces; and after performing miracles of personal strength and courage, was obliged to return to the Vatican. There he found the pope in mortal agony: the Orsini, tired of contending against the old man's word of honour pledged to the duke, had by the interposition of Pandolfo Petrucci, gained the ear of the pope's surgeon, who placed a poisoned plaster upon a wound in his leg.
The pope then was actually dying when Caesar, covered with dust and blood, entered his room, pursued by his enemies, who knew no check till they reached the palace walls, behind which the remnant of his army still held their ground.
Pius III, who knew he was about to die, sat up in his bed, gave Caesar the key of the corridor which led to the Castle of Sant' Angelo, and an order addressed to the governor to admit him and his family, to defend him to the last extremity, and to let him go wherever he thought fit; and then fell fainting on his bed.
Caesar took his two daughters by the hand, and, followed by the little dukes of Sermaneta and Nepi, took refuge in the last asylum open to him.
The same night the pope died: he had reigned only twenty-six days.
After his death, Caesar, who had cast himself fully dressed upon his bed, heard his door open at two o'clock in the morning: not knowing what anyone might want of him at such an hour, he raised himself on one elbow and felt for the handle of his sword with his other hand; but at the first glance he recognised in his nocturnal visitor Giuliano della Rovere.
Utterly exhausted by the poison, abandoned by his troops, fallen as he was from the height of his power, Caesar, who could now do nothing for himself, could yet make a pope: Giuliano della Rovere had come to buy the votes of his twelve cardinals.
Caesar imposed his conditions, which were accepted.
If elected, Giuliano della Rovere was to help Caesar to recover his territories in Romagna; Caesar was to remain general of the Church; and Francesco Maria della Rovere, prefect of Rome, was to marry one of Caesar's daughters.
On these conditions Caesar sold his twelve cardinals to Giuliano.