Complete Division of a Mixed Nerve.—Complete division is a common result of accidental wounds, especially above the wrist, where the ulnar, median, and radial nerves are frequently cut across, and in gun-shot injuries.
Changes in Structure and Function.—The mere interruption of the continuity of a nerve results in degeneration of its fibres, the myelin being broken up into droplets and absorbed, while the axis cylinders swell up, disintegrate, and finally disappear. Both the conducting and the insulating elements are thus lost. The degeneration in the central end of the divided nerve is usually limited to the immediate proximity of the lesion, and does not even involve all the nerve fibres. In the distal end, it extends throughout the entire peripheral distribution of the nerve, and appears to be due to the cutting off of the fibres from their trophic nerve cells in the spinal medulla. Immediate suturing of the ends does not affect the degeneration of the distal segment. The peripheral end undergoes complete degeneration in from six weeks to two months.
The physiological effects of complete division are that the muscles supplied by the nerve are immediately paralysed, the area to which it furnishes the sole cutaneous supply becomes insensitive, and the other structures, including tendons, bones, and joints, lose sensation, and begin to atrophy from loss of the trophic influence.
Nerves divided in Amputation.—In the case of nerves divided in an amputation, there is an active, although necessarily abortive, attempt at regeneration, which results in the formation of bulbous swellings at the cut ends of the nerves. When there has been suppuration, and especially if the nerves have been cut so as to be exposed in the wound, these bulbous swellings may attain an abnormal size, and are then known as “amputation” or “stump neuromas” ([Fig. 84]).
When the nerves in a stump have not been cut sufficiently short, they may become involved in the cicatrix, and it may be necessary, on account of pain, to free them from their adhesions, and to resect enough of the terminal portions to prevent them again becoming adherent. When this is difficult, a portion may be resected from each of the nerve-trunks at a higher level; and if this fails to give relief, a fresh amputation may be performed. When there is agonising pain dependent upon an ascending neuritis, it may be necessary to resect the corresponding posterior nerve roots within the vertebral canal.
Fig. 84.—Stump Neuromas of Sciatic Nerve, excised forty years after the original amputation by Mr. A. G. Miller.
Other Injuries of Nerves.—Contusion of a nerve-trunk is attended with extravasation of blood into the connective-tissue sheaths, and is followed by degeneration of the contused nerve fibres. Function is usually restored, the conducting paths being re-established by the formation of new nerve fibres.
When a nerve is torn across or badly crushed—as, for example, by a fractured bone—the changes are similar to those in a divided nerve, and the ultimate result depends on the amount of separation between the ends and the possibility of the young axis cylinders bridging the gap.