Manual of Surgery Volume Second: Extremities—Head—Neck. Sixth Edition.

by Alexis Thomson; Alexander Miles

With the growth of the tumour the symptoms become aggravated, the optic neuritis is followed by optic atrophy and blindness, the patient gradually becomes stuporous, and finally dies in a state of coma. The severity of the symptoms depends to a large extent on the rapidity of growth of the tumour; thus an osteoma growing slowly from the inner table of the skull and implicating the brain may reach a considerable size without producing cerebral symptoms, while a comparatively small sarcoma or syphilitic gumma of rapid growth may endanger life. A sudden and serious aggravation of symptoms may result from hæmorrhage into a soft tumour, such as glioma.

The diagnosis of the pathological nature of a cerebral tumour is generally “hardly more than a guess” (Gowers). At the same time it may be borne in mind that syphilitic gummata occur in adults, from forty to sixty years of age, who have suffered from acquired syphilis, and who may present other evidence of the disease. They tend to increase somewhat rapidly. A negative Wassermann reaction does not necessarily exclude a diagnosis of brain syphilis. Severe nocturnal pain which interferes with sleep is often a prominent symptom. Gummata are generally situated on the surface of the brain; they often originate in the dura mater, and when exposed are easily enucleated. Improvement in the symptoms may follow the administration of iodides and mercury, or organic arsenical salts of the salvarsan group, but in many cases the growth is very resistant to anti-syphilitic treatment.

Tuberculous masses occur most frequently in children and adolescents, and other signs of tuberculosis are usually present. The cerebellum is a common seat of these tumours, and they are often multiple. Their growth may be rapid at first, and then become arrested for a time. Spasmodic growth of a tumour strongly suggests its tuberculous nature, and superadded signs of basal meningitis confirm the diagnosis.

Endothelioma grows from the dura mater, and in so far as it is a well-defined and non-infiltrating growth it lends itself to removal by operation. Unfortunately, however, it is usually located at the base of the brain and is not readily accessible.

Glioma is usually met with in the young; it tends to grow slowly at first, but may take on a rapid growth at any time, and hæmorrhage is liable to occur into the substance of the tumour, causing a sudden aggravation of the symptoms.

Sarcoma occurs between puberty and middle life; it grows slowly, and compresses rather than destroys the brain tissue. It is sharply defined from the surrounding cerebral tissue, and is therefore more favourable for operation than glioma.

The prognosis is grave in all forms of brain tumour. Even in syphilitic growths, although the more urgent symptoms may be ameliorated by the use of drugs, recurrence is liable to occur, and the structural changes induced in the cerebral tissue, and the contraction of the cicatrix which results, may permanently interfere with the functions of the brain, or may induce Jacksonian epilepsy. Tuberculous tumours also may become arrested, and may cease for a time to cause symptoms, but permanent cure is extremely rare. We have known a sarcoma to recur as late as five years after removal. Death sometimes occurs suddenly from hæmorrhage, from acute œdema, or from implication of vital centres.

Treatment.—It is to be borne in mind that gummatous growths in the brain are seldom influenced to any extent by anti-syphilitic remedies, and time should not be wasted in trying this form of treatment.

The question of removal by operation arises in cases in which there is reason to believe that the tumour is situated near the surface of the brain and that it is circumscribed and of moderate size. Unfortunately it is only in a small proportion of cases that these conditions are present and can be recognised before opening the skull.

In many cases in which there is no hope of being able to remove the tumour, it is advisable to relieve symptoms due to excessive intra-cranial tension, such as blindness, severe headache, and persistent vomiting, by performing a “decompression operation” (Operative Surgery, p. 108). The relief that follows such operations is often remarkable.