The immediate cause of her attacks would generally seem to have been excitement or over-fatigue causing, in the first instance, loss of sleep, a feverish restlessness and ending in the complete overthrow of reason. "Her relapses," says Proctor, "were not dependent on the seasons; they came in hot summer and with the freezing winters. The only remedy seems to have been extreme quiet when any slight symptom of uneasiness was apparent. If any exciting talk occurred Charles had to dismiss his friend with a whisper. If any stupor or extraordinary silence was observed then he had to rouse her instantly. He has been seen to take the kettle from the fire and place it for a moment on her headdress, in order to startle her into recollection." Once the sudden announcement of the marriage of a young friend—whose welfare she had at heart—restored her, in a moment, after a protracted illness, "as if by an electrical stroke, to the entire possession of her senses." But if no precautions availed to remove the premonitory symptom, then would Mary "as gently as possible prepare her brother for the duty he must perform; and thus, unless he could stave off the terrible separation till Sunday, oblige him to ask leave of absence from the office, as if for a day's pleasure—a bitter mockery! On one occasion Mr. Charles Lloyd met them slowly pacing together a little foot-path in Hoxton fields, both weeping bitterly and found, on joining them, that they were taking their solemn way to the accustomed asylum." Holiday trips were almost always followed by a seizure; and never did Mary set out on one but with her own hands she packed a strait-waistcoat.

The attacks were commonly followed by a period of extreme depression, a sense of being shattered, and by a painful loss of self-reliance. These were but temporary states, however. Mary's habitual frame of mind was, as Talfourd says, serene and capable of placid enjoyment. In her letters to Sarah Stoddart there are some affecting and probably unique disclosures of how one who is suffering from madness feels; and what, taught by her own experience, Mary regarded as the most important points in the management of the insane. In reference to her friend's mother who was thus afflicted, she writes:—

"Do not, I conjure you, let her unhappy malady afflict you too deeply. I speak from experience and from the opportunity I have had of much observation in such cases that insane people, in the fancies they take into their heads, do not feel as one in a sane state of mind does under the real evil of poverty, the perception of having done wrong, or of any such thing that runs in their heads.

"Think as little as you can, and let your whole care be to be certain that she is treated with tenderness. I lay a stress upon this because it is a thing of which people in her state are uncommonly susceptible, and which hardly anyone is at all aware of; a hired nurse never, even though in all other respects they are good kind of people. I do not think your own presence necessary, unless she takes to you very much, except for the purpose of seeing with your own eyes that she is very kindly treated.

"I do long to see you! God bless and comfort you."

And again, a few weeks later:—

"After a very feverish night I writ a letter to you and I have been distressed about it ever since. That which gives me most concern is the way in which I talked about your mother's illness, and which I have since feared you might construe into my having a doubt of your showing her proper attention without my impertinent interference. God knows, nothing of this kind was ever in my thoughts, but I have entered very deeply into your affliction with regard to your mother; and while I was writing, the many poor souls in the kind of desponding way she is whom I have seen came fresh into my mind, and all the mismanagement with which I have seen them treated was strong in my mind, and I wrote under a forcible impulse which I could not at the time resist, but I have fretted so much about it since that I think it is the last time I will ever let my pen run away with me.

"Your kind heart will, I know, even if you have been a little displeased, forgive me when I assure you my spirits have been so much hurt by my last illness, that, at times, I hardly know what I do. I do not mean to alarm you about myself, or to plead an excuse; but I am very much otherwise than you have always known me. I do not think anyone perceives me altered, but I have lost all self-confidence in my own actions, and one cause of my low spirits is that I never feel satisfied with anything I do—a perception of not being in a sane state perpetually haunts me. I am ashamed to confess this weakness to you; which, as I am so sensible of, I ought to strive to conquer. But I tell you, that you may excuse any part of my letter that has given offence; for your not answering it, when you are such a punctual correspondent, has made me very uneasy.

"Write immediately, my dear Sarah, but do not notice this letter, nor do not mention anything I said relative to your poor mother. Your handwriting will convince me you are friends with me; and if Charles, who must see my letter, was to know I had first written foolishly and then fretted about the event of my folly, he would both ways be angry with me.

"I would desire you to direct to me at home, but your hand is so well known to Charles that that would not do. Therefore, take no notice of my megrims till we meet, which I most ardently long to do. An hour spent in your company would be a cordial to my drooping heart.