Like the hairs, the [sebaceous glands] are situated in all parts of the body except the palms of the hands and the soles of the feet. They lie in the papillary layer and empty into the hair follicles, except occasionally, when they empty directly upon the surface of the skin. They secrete an oily substance, sebum, the débris resulting from the degeneration of the epithelial cells of the gland itself, which serves to keep the hair glossy and the skin soft and flexible.

The [sweat glands], on the other hand, are more frequent on the palms and soles and though sometimes found in the derma are usually situated lower down in the subcutaneous cellular tissue. They are least numerous on the back and neck. Coiled up in the lower layers of the skin, they discharge the sweat through a spiral excretory duct upon its free surface.

The sweat is a clear, colorless, watery fluid with a salty taste, an alkaline reaction, and a characteristic odor that varies with the individual. If very scanty, it may be acid in reaction. Besides water it contains a small percentage of solids, as inorganic salts, especially sodium chloride, fatty acids, neutral fats, and at times, especially in some diseases of the kidneys, urea, that is, the end-products of the metabolism of starches and fats chiefly. There is usually also some carbon dioxide, whence the expression cutaneous respiration.

The sweat serves to keep the skin moist and in good condition, to remove outworn and poisonous or irritating matters, and to regulate the temperature. As a rule it evaporates upon reaching the surface, in which case it is known as invisible or insensible perspiration, but if conditions of the atmosphere are not favorable to prompt evaporation, as when the air is damp, the skin becomes damp and there is visible perspiration.

Though an abundant supply of blood increases the action of the sweat glands, they are regulated by definite secretory nerves rather than by the vasomotor nerves. In a cold sweat the action is probably due to some disturbance of the nerve supply without increase of the blood supply. Ordinarily perspiring is a reflex act due to the stimulation of the afferent cutaneous nerves, as by the application of heat, but sometimes, as in cases of strong emotions, involuntary impulses are sent from the brain to the spinal centers and so arouse the action of the glands. Atropin has the power of preventing the secretion of sweat by paralyzing the terminations of the secretory nerves, while pilocarpin produces an opposite effect in a similar way.

On account of these sweat glands the skin becomes next in importance after the kidneys in the excretion of waste products. The quantity of sweat excreted varies greatly and is hard to measure. It is influenced by the temperature and humidity of the surrounding air, by the nature and quantity of food and drink consumed, by the amount of exercise, the relative activity of other organs, especially the [kidneys], and by certain mental conditions. The hotter it is, the greater the amount of perspiration. In damp weather there may be less perspiration, but it does not evaporate and is therefore more in evidence.

Ordinarily man has a temperature of 98.6°. The source of this body heat or temperature is the general body metabolism, muscular activity, and activity of the glands, especially of the liver, which is constantly active, the blood in the hepatic vein being warmer than that in any other part of the body. The tissue of the brain also is said to be warmer than the surrounding blood, and the heart and respiratory muscles, which are in constant activity, are responsible for much of the body heat. The amount of heat generated in the body, therefore, varies at different times, according as a person is awake or asleep, quiet or active.

Temperature Regulation.—The temperature is regulated by variations in the production and loss of heat, less being known of its production than of its loss. It has been calculated that four-fifths of the energy of the body is converted into heat, one-fifth into work. As the minimum amount of heat produced in twenty-four hours is sufficient to raise 10 gallons of water from 0° to boiling-point, it is evident that if there were not some way for the escape of much of this heat the body would become hotter and hotter and finally destroy itself. The temperature, however, except on the surface, is uniform, heat being lost as fast as it is produced. For, although oxidation at any point raises the heat of the blood at the point, this heat is carried by the blood to other parts, to which the surplus is given up, while blood cooled in the skin goes to the hotter inward parts to cool them and be warmed itself. In fact, heat is expended by conduction and radiation, through respiration, perspiration, and heat given to the urine and fæces. It is, therefore, largely, 75 to 80 per cent., carried off through the skin and the lungs; 60 to 70 per cent. is lost by radiation to the air and other bodies with which the body comes in contact; 20 to 30 per cent. is lost by the evaporation of sweat, 4 to 8 per cent. by the warming of expired air, urine and feces, and 1 to 2 per cent. by cold food that is taken in. Radiation acts more favorably where the surroundings are cool and the air in motion, as on a breezy day. Conduction is carried on best where the surrounding air is cool, especially if it is moist, for moist air is a better conductor of heat than dry air. Evaporation is very important in hot weather or where men work in hot air.

Even in health the temperature may range from 98.6° to 99.5°, and a degree or two below or above is not dangerous. When a person first gets up in the morning his temperature is apt to be subnormal, but after food and exercise have been taken it becomes normal and stays so till the end of the day, when, if the person is tired, it may go up a little. If a person is tired out, the temperature is apt to be subnormal. There is also in the body what is called the vital tide, which is highest afternoon and evening and lowest in the morning.

The rate of production of heat varies greatly in different people. One person uses a certain amount of tissue more quickly than another, that is, he lives faster. Moreover, size makes a difference in that a small body has more surface to its weight than a large one and so has to produce the same amount of heat at a faster rate in order to maintain the right temperature. Taking food increases heat, probably because of the muscular effort needed to eat it. Muscular work is another factor. And finally the whole matter of heat production seems to be under the control of the nervous system. Not much is known on this point except that there is a heat center in the medulla which plays an important part in heat production and whose influence is seen where the temperature shoots way up in disease just before death. It is now thought that fever is due to a disturbance of this nervous mechanism, though just what the disturbance is is not known.