Is it not impossible to get it so from the stomach?—It is not impossible; it depends upon the quantity which remains there.
You do not agree that the fiftieth part of a grain might be discovered?—I think not.
Nor even half a grain?—That might be. It would depend upon the quantity of food in the stomach with which it was mixed.
Re-examined by the Attorney-General: In case of death from strychnia the heart is sometimes found empty after death. That is the case of human subjects. There are three such cases on record. I think that emptiness results from spasmodic affection of the heart. I know of no reason why that should rather occur in the case of man than in that of a small animal like a rabbit. The heart is generally more filled when the paroxysms are more frequent. When the paroxysm is short and violent, and causes death in a few moments, I should expect to find the heart empty. The rigidity after death always affects the same muscles—those of the limbs and back. In the case of the rabbit, in which the rigidity was relaxed at the time of death, it returned while the body was warm. In ordinary death it only appears when the body is cold, or nearly so. I never knew a case of tetanus in which the rigidity lasted two months after death; but such a fact would give me the impression that there were very violent spasms. It would indicate great violence of the spasms from which the person died. The time which elapses between the taking of strychnia and the commencement of the paroxysms depends on the constitution and strength of the individual. A feeling of suffocation is one of the earliest symptoms of poisoning by strychnia, and that would lead the patient to beat the bed-clothes. I have no doubt that the substances I used for the analysis were pure. I had tested them. The fact that in three distinct processes each gave the same result, was strong confirmation of each. I have no doubt that what we found was antimony. The quantity found does not enable me to say how much was taken. It might be the residue of either large or small doses. Sickness would throw off some portion of the antimony, which had been administered. We did not analyse the bones and tissues.
Why did you suggest questions to the coroner?—He did not put questions which enabled me to form an opinion. I think that arose rather from want of knowledge than from intention. There was an omission to take down the answers. I made no observation upon that subject. At the time I wrote to Mr. Gardner I had not learnt the symptoms which attended the attack and death of Cook. I had only the information that he was well seven days before he died, and had died in convulsions. I had no information which could lead me to suppose that strychnia had been the cause of death, except that Palmer had purchased strychnia. Failing to find opium, prussic acid, or strychnia, I referred to antimony, as the only substance found in the body. Before writing to the Lancet, I had been made the subject of a great many attacks. What I said as to the possibility or impossibility of discovering strychnia after death had been misrepresented. In various newspapers it had been represented that I had said that strychnia could never be detected—that it was destroyed by putrefaction. What I said was, that when absorbed into the blood it could not be separated as strychnia. I wrote the letter for my own vindication.
Dr. G. O. Rees, examined by Mr. E. James, Q.C., said: I am Lecturer on Materia Medica at Guy’s Hospital, and I assisted Dr. Taylor in making the post-mortem examination referred to by that gentleman; and he has most correctly stated the result. I was present during the whole time, and at the discovery of the antimony. I am of opinion that it may have been administered within a few days, or a few hours, of Mr. Cook’s death. All the tests we employed failed to discover the presence of strychnia. The stomach was in a most unfavourable state for examination; it was cut open, and turned inside out; its mucous surface was lying upon the intestines, and the contents of the stomach, if there had been any, must have been thrown among the intestines, and mixed with them. These circumstances were very unfavourable to the hope of discovering strychnia. I agree with Dr. Taylor as to the manner in which strychnia acts upon the human frame, and I am of opinion that it may be taken, either by accident or design, sufficient to destroy life, and no trace of it be found after death. I was present at the experiments made by Dr. Taylor upon the animals, and at the endeavour to detect it in the stomachs afterwards. We failed to do so in three cases out of four. The symptoms accompanying the death of the animals were very similar to those described in the case of Mr. Cook. I have heard the cases that have been mentioned in this Court, and the symptoms in every one of them are analogous to those in the case of Mr. Cook.
Cross-examined by Mr. Grove, Q.C.: I did not see either of the animals reject any portion of the poison; but I heard that in one case the animal did reject a portion. I have no facts to state upon which I formed the opinion that the poison acts by absorption.
Professor Brande, examined by Mr. Welsby: I am Professor of Chemistry at the Royal Institution. I was not present at the analysis of the liver, spleen, &c., of the deceased; but the report of Dr. Taylor and Dr. Rees was sent to me for my inspection afterwards. I was present at one of the analyses. We examined in the first place the action of copper upon a very weak solution of antimony, and we ascertained that there was no action until the solution was slightly acidified by muriatic acid and heated. The antimony was then deposited, and I am enabled to state positively that the deposit was antimony.
By the Attorney-General: The experiment I refer to was made for the purpose of testing the accuracy of the test that had already been applied, and it was perfectly satisfactory.
Professor Christison said: I am a Fellow of the Royal College of Physicians, and Professor of Materia Medica to the University of Edinburgh; I am also the author of a work on the subject of poisons, and I have directed a good deal of attention to strychnia. In my opinion, it acts by absorption into the blood, and through that upon the nervous system. I have seen its effects on a human subject, but not a fatal case. I have seen it tried upon pigs, rabbits, cats, and one wild boar. (A laugh.) I first directed my attention to this poison in 1820, in Paris. It had been discovered two years before in Paris. In most of my experiments upon animals I gave very small doses—a sixth of a grain; but I once administered a grain. I cannot say how small a dose would cause the death of an animal by administration into the stomach. I generally applied it by injection through an incision in the cavity of the chest. A sixth part of a grain so administered killed a dog in two minutes. I once administered to a rabbit, through the stomach, a dose of a grain. I saw Dr. Taylor administer three-quarters of a grain to a rabbit, and it was all swallowed, except a very small quantity. The symptoms are nearly the same in rabbits, cats, and dogs. The first is a slight tremor and unwillingness to move; then frequently the animal jerks its head back slightly; soon after that all the symptoms of tetanus come on, which have been so often described by the previous witnesses. When the poison is administered by the stomach, death generally takes place between a period of five minutes and five-and-twenty minutes after the symptoms first make their appearance. I have frequently opened the bodies of animals thus killed, and have never been able to trace any effect of the poison upon the stomach or intestines, or upon the spinal cord or brain, that I could attribute satisfactorily to the poison. The heart of the animal generally contained blood in all the cases in which I have been concerned. In the case of the wild boar the poison was injected into the chest. A third of a grain was all that was used, and in ten minutes the symptoms began to show themselves. If strychnia was administered in the form of a pill, it might be mixed with other ingredients that would protract the period of its operation. This would be the case if it were mixed with resinous materials, or any materials that were difficult of digestion, and such materials would be within the knowledge of any medical men, and they are frequently used for the purpose of making ordinary pills. Absorption in such a case would not commence until the pill was broken down by the process of digestion.