Immediately on the right, the steep "Salita di S. Onofrio" leads up the hillside to the Church of S. Onofrio, built in 1439 by Nicolo da Forca Palena, in honour of the Egyptian hermit, Honophrius.

"St. Onofrius was a monk of Thebes, who retired to the desert, far from the sight of men, and dwelt there in a cave for sixty years, and during all that time never beheld one human being, or uttered one word of his mother-tongue except in prayer. He was unclothed, except by some leaves twisted round his body, and his beard and hair had become like the face of a wild beast. In this state he was discovered by a holy man whose name was Paphnutius, who, seeing him crawling on the ground, knew not at first what live thing it might be."—Jameson's Sacred Art.

From the little platform in front of the convent is one of the loveliest views over the city. The church is approached by a portico, decorated with glazed frescoes by Domenichino. Those on either side of the door represent the saints of the Hieronomyte Order (the adjoining convent belongs to Hieronomytes), viz.: S. Jerome, Sta. Paula, St. Eustochium, S. Pietro Gambacorta of Pisa, St Augustine the hermit, S. Nicolo di Forca Palena, S. Onofrio and the Blessed Benedict of Sicily, Philip of St. Agatha, Paul of Venice, Bartholomew of Cesarea, Mark of Manuta, Philip of Fulgaria, and John of Catalonia. Over the door is a Madonna and Child. In the side arcade are three scenes in the life of St. Jerome. 1. Represents his baptism as a young man at Rome. 2. Refers to his vision of the Judgment (described in his letter to Eustochium), in which he heard the Judge of the World ask what he was, and he answered, "I am a Christian." But the Judge replied, "No, you lie, for you are a Ciceronian," and he was condemned to be scourged, but continued to protest that he was a Christian between every lash. 3. Is a scene alluded to in another letter to Eustochium, in which Jerome says, "O how often when alone in the desert with the wild beasts and scorpions, half dead with fasting and penance, have I fancied myself a spectator of the sins of Rome, and of the dances of its young women."

The church has a solemn and picturesque interior. It ends in a tribune richly adorned with frescoes, those of the upper part (the Coronation of the Virgin, and eight groups of saints and angels) being by Pinturicchio, those of the lower (the Virgin and Saints, Nativity, and Flight into Egypt) by Baldassare Peruzzi.

On the left of the entrance is the original monument of Tasso (with a portrait), erected after his death by Cardinal Bevilacqua. Greatly inferior in interest is a monument recently placed to his memory in the adjoining chapel, by subscription, the work of De Fabris. Near this is the grave of the poet, Alessandro Guidi, ob. 1712. In the third chapel on the left is the grave of the learned Cardinal Mezzofanti, born at Bologna, 1774, died at Rome, 1849.

The first chapel on the right, which is low and vaulted, with stumpy pillars, is covered with frescoes relating to S. Onofrio.

The second chapel on the right, which is very richly decorated, contains a Madonna crowned by Angels, by Annibale Caracci. Beyond this is the fine tomb of Archbishop Sacchi, ob. 1502. The beautiful lunette, of the Madonna teaching the Holy Child to read, is by Pinturicchio. The tomb is inscribed:

"Labor et gloria vita fuit,
Mors requies."

Ladies are never admitted to visit the convent, except on April 25th, the anniversary of the death of Tasso. It is approached by a cloister, decorated with frescoes from the life of S. Onofrio.

"S. Onofrio is represented as a meagre old man, with long hair and beard, grey and matted, a leafy branch twisted round his loins, a stick in his hand. The artist generally tries to make him look as haggard and inhuman as possible."—Mrs. Jameson.