SS. Cosmo and Damian, to whom this church is dedicated, were two Arabian physicians who exercised their art from charity. They suffered under Diocletian. "First they were thrown into the sea, but an angel saved them; and then into the fire, but the fire refused to burn them; then they were bound to crosses and stoned, but the stones either fell harmless or rebounded on their executioners and killed them, so then the pro-consul Lycias, believing them to be sorcerers, commanded that they should be beheaded, and thus they died." SS. Cosmo and Damian were the patron saints of the Medici, and their gilt statues were carried in state at the coronation of Leo X. (Giovanni de' Medici). Their fame is general in many parts of France, where their fête is celebrated by a village fair—children who ask for their fairing of a toy or gingerbread calling it their "St. Côme."

"It is related that a certain man, who was afflicted with a cancer in his leg, went to perform his devotions in the Church SS. Cosmo and Damian at Rome, and he prayed most earnestly that these beneficent saints would be pleased to aid him. When he had prayed, a deep sleep fell upon him. Then he beheld St. Cosmo and St. Damian, who stood beside him; and one carried a box of ointments, and the other a sharp knife. And one said, 'What shall we do to replace this diseased leg when we have cut it off?' And the other replied, 'There is a Moor who has been buried just now at St. Pietro in Vincoli; let us take his leg for the purpose.' So they brought the leg of the dead man, and with it they replaced the leg of the sick man; anointing it with celestial ointment, so that he remained whole. When he awoke he almost doubted whether it could be himself; but his neighbours, seeing that he was healed, looked into the tomb of the Moor, and found that there had been an exchange of legs: and thus the truth of this great miracle was proved to all beholders."—Mrs. Jameson, from the Legenda Aurea.

Just beyond the basilica of Constantine, stands the Church of Sta. Francesca Romana, which is full of interest. It was first built by St. Sylvester on the site of the temple of Venus and dedicated to the Virgin, under the title of Sta. Maria Antica. It was rebuilt in A.D. 872 by John VIII., who resided in the adjoining monastery during his pontificate. An ancient picture attributed to St. Luke, brought from Troy in 1100, was the only object in this church which was preserved when the building was totally destroyed by fire in 1216, after which the church, then called Sta. Maria Nuova, was restored by Honorius III. During the restoration, the picture was kept at S. Adriano, and its being brought back led to a contest amongst the people, which was ended by a child exclaiming—"What are you doing? the Madonna is already in her own church." She had betaken herself thither none knew how.

In the twelfth century the church was given to the Lateran Canons, in the fourteenth to the Olivetan monks; under Eugenius IV., the latter extended their boundaries so far that they included the Coliseum, but their walls were forced down in the succeeding pontificate. Gregory XI., Paul II., and Cæsar Borgia, were cardinals of Sta. Maria Novella. In 1440 the name was changed to that of Sta. Francesca Romana, when that saint, Francesca de' Ponziani, foundress of the Order of Oblates, was buried here. Her tomb was erected in 1640 by Donna Agata Pamfili, sister of Innocent X., herself an Oblate. It is from the designs of Bernini, and is rich in marbles. The figure was not added till 1868.

"After the death of Francesca, her body remained during a night and a day at the Ponziani Palace, the Oblates watching by turns over the beloved remains.... Francesca's face, which had recently borne traces of age and suffering, became as beautiful again as in the days of youth and prosperity; and the astonished bystanders gazed with wonder and awe at her unearthly loveliness. Many of them carried away particles from her clothes, and employed them for the cure of several persons who had been considered beyond the possibility of recovery. In the course of the day the crowd augmented to a degree which alarmed the inhabitants of the palace, Battista Ponziani took measures to have the body removed at once to the church, and a procession of the regular and secular clergy escorted the venerated remains to Santa Maria Nuova, where they were to be interred.

"The popular feeling burst forth on the occasion; it was no longer to be restrained. Francesca was invoked by the crowd, and her beloved name was heard in every street, in every piazza, in every corner of the Eternal City. It flew from mouth to mouth, it seemed to float in the air, to be borne aloft by the grateful enthusiasm of a whole people, who had seen her walk to that church by her mother's side in her holy childhood; who had seen her kneel at that altar in the grave beauty of womanhood, in the hour of bereavement, and now in death, carried thither in state, she the gentle, the humble saint of Rome, the poor woman of the Trastevere, as she was sometimes called at her own desire."—Lady G. Fullerton's Life of Sta. Francesca Romana.

A chapel on the right of the church contains the monument of Cardinal Vulcani, 1322, supporting his figure, with Faith, Hope, and Charity sculptured in high relief below. Near the door is that of Cardinal Adimari, 1432, who died here after an ineffectual mission to the anti-pope Pedro da' Luna. In the left transept was a fine Perugino (removed 1867); in the right transept is the tomb of Pope Gregory XI., by Pietro Paolo Olivieri, erected by the senate in gratitude for his having restored the papal court to Rome from Avignon. A bas-relief represents his triumphal entry, with St. Catherine of Siena, by whose entreaties he was induced to return, walking before his mule. A breach in the walls indicates the ruinous state into which Rome had fallen, the chair of St. Peter is represented as floating back through the air, while an angel carries the papal tiara and keys; a metaphorical figure of Rome is coming forth to welcome the pope.

"The greatest part of the praise due to Gregory's return to Rome belongs to St. Catherine of Siena, who, with infinite courage, travelled to Avignon, and persuaded the pope to return, and by his presence to dispel the evils which disgraced Italy, in consequence of the absence of the popes. Thus it is not to be wondered at, that those writers, who rightly understand the matter, should have said that Catherine, the virgin of Siena, brought back to God the abandoned apostolical chair upon her shoulders."—Ughelli, Ital. Sacra, vi. col. 45.

Near Pope Gregory's tomb some blackened marks in the wall are shown as holes made by the (gigantic) knees of St. Peter, when he knelt to pray that Simon Magus might be dropped by the demons he had invoked to support him in the air, which he is said to have done to show his power on this spot.

"When the error of Simon was spreading farther and farther, the illustrious pair of men, Peter and Paul, the rulers of the Church, arrested it by going thither, who suddenly exhibited as dead, Simon, the putative God, on his appearance. For when Simon declared that he would ascend aloft into heaven, the servants of God cast him headlong to the earth, and though this occurrence was wonderful in itself, it was not wonderful under the circumstances, for it was Peter who did it, he who bears with him the keys of heaven, ... it was Paul who did it, he who was caught up into the third heaven."—St. Cyril of Jerusalem.