Lewis, undisputed master of Milan and Genoa, assured of the Roman and the Venetian alliance, was in a better position than his predecessor to renew the claim on the throne of Naples. But now, behind Frederic of Naples, there was Ferdinand of Aragon and Sicily, who was not likely to allow the king for whom he had fought to be deposed without resistance. Therefore it was a welcome suggestion when Ferdinand proposed that they should combine to expel Frederic and to divide his kingdom. As it was Ferdinand who had just reinstated him, this was an adaptation to the affairs of Christendom of the methods which passed for justice in the treatment of unbelievers, and were applied without scruple by the foremost men of the age, Albuquerque and Cortez. Frederic turned for aid to the Sultan, and this felonious act was put forward as the justification of his aggressors. The Pope sanctioned the Treaty of Partition, and as the Crown of Naples was technically in his gift, he deprived the king on the ground stated by the allies. The exquisite significance of the plea was that the Pope himself had invited Turkish intervention in Italy, and now declared it a cause of forfeiture. In 1501 French and Spaniards occupied their allotted portions, and then quarrelled over the distribution of the spoil. For a time Gonsalvo, "the great Captain," was driven to bay at Barletta on the Adriatic; but at the end of 1503 he won a decisive victory, and the defeated French, under Bayard, withdrew from the Garigliano to the Po. Naples remained a dependency of Spain, for all purposes, in modern history.

In the midst of foreign armies, and of new combinations disturbing the established balance of Italian Powers, the lesser potentates were exposed to destruction; and there were forces about sufficient, under capable guidance, to remodel the chaotic centre of Italy, where no strong government had ever been constituted. Caesar Borgia recognised the opportunity as soon as the French were at Milan; the Pope was growing old and was clay in his terrible hands. His sister just then became Duchess of Ferrara, on the border of the defenceless region which he coveted; and the dominions of the King of France, his patron and ally, extended to the Adda and the Po. Never had such advantages been united in such a man. For Caesar's talents were of the imperial kind. He was fearless of difficulties, of dangers, and of consequences; and having no preference for right or wrong, he weighed with an equal and dispassionate mind whether it was better to spare a man or to cut his throat. As he did not attempt more than he could perform, his rapid success awakened aspirations for a possible future. He was odious to Venice, but a Venetian, who watched his meteoric course, wonders, in his secret diary, whether this unerring schemer was to be the appointed deliverer. He was a terror to Florence, yet the Florentine secretary, to whom he confided his thoughts in certain critical hours, wrote of him as men have written of Napoleon, and erected a monument to his memory that has secretly fascinated half the politicians in the world.

With his double equipment as a lieutenant of the French king and as a condottiere of the Pope, he began by reviving the dormant authority of Rome, where nominal feudatories held vicarious sway. In the place of many despots struggling not for objects of policy, but for their own existence, there appeared a single state, reaching from sea to sea, from the Campagna to the salt-marshes by the delta of the Po, under a papal prince and gonfaloniere, invested with rights and prerogatives to protect the Holy See, and with power to control it. Rome would have become a dependency of the reigning house of Borgia, as it had been of less capable vassals, and the system might have lasted as long as the brain that devised it. Lorenzo de' Medici once said that his buildings were the only works that would outlast him; and it is common in the secular characters of that epoch, unlike the priesthood, not to believe in those things that are abiding, and not to regard organisations that are humble and obscure at first and bloom by slow degrees for the use of another age.

Caesar's enterprise was not determined or limited by the claims of the Vatican. He served both Pope and king, and his French alliance carried farther than the recovery of the Romagna. Florence became tributary by taking him into pay. Bologna bought him off with a heavy ransom. Venice inscribed his name in the illustrious record of its nobility. None could tell where his ambition or his resources would end, how his inventive genius would employ the rivalry of the invaders, what uses he would devise for the Emperor and the Turk. The era of petty tyranny was closed by the apparition of one superior national tyrant, who could be no worse than twenty, for though his crimes would be as theirs, they would not be useless to the nation, but were thoughtfully designed and executed for the sake of power, the accepted object of politics in a country where the right was known by the result. Caesar was not an unpopular master, and his subjects were true to him in his falling fortunes. The death of Alexander and the decline of the French cause in the South cut short his work in the autumn of 1503. Della Rovere, Cardinal Vincula, whose title came from the Church of St. Peter in Chains, the inflexible enemy of the Borgias, was now Julius II; and after a brief interval he was strong enough to drive Caesar out of the country; while the Venetians, entering the Romagna under ill omens for the Republic, occupied the remnant of his many conquests.

Julius had resisted Alexander, as a man unfit for his function, and it soon appeared that this was not a private feud, but a total reversal of ideas and policy. The change was not felt in religious reform or in patronage of learning, but first in the notion of territorial politics. Caesar had rebuilt the duchy of Romagna in the service of the papacy; and it was the essence of the schemes of Julius that it should be secured for the Holy See, together with all else that could be claimed by right, or acquired by policy and war. The Borgias had prevailed by arms, and Julius would not consent to be their inferior and to condemn his whole career. He must draw the sword; but, unlike them, he would draw it in the direct interest of the Church. He had overthrown the conqueror, not that the conquests might be dissolved, or might go to Venice, but in order that he himself and his successors might have power in Italy, and through Italians, over the world. Upon this foundation he instituted the temporal power, as it subsisted for three centuries. The jealous municipal spirit of the Middle Ages had dissolved society into units, and nothing but force could reverse the tradition and weld the fragments into great communities. Borgia had shown that this could be done; but also that no victorious condottiere, were he even his own son, could be trusted by a Pope. Julius undertook to command his army himself, and to fight at the head of his troops. Letting his white beard grow, putting on armour, and proudly riding his war-horse under fire, he exhibited the most picturesque and romantic figure of his time.

The Venetians, commanding the seaboard with their galleys, were not easy to dislodge from the towns they occupied. Essentially a maritime and commercial Power, their centre of gravity lay so far east that it was once proposed to move the capital from the Lagoons to the Bosphorus. When the advancing Turk damaged their trade and threatened their Colonial empire, they took advantage of Italian disintegration to become a continental state, and the general insecurity and oppression of miniature potentates made it a happy fate to be subject to the serene and politic government, whose 3000 ships still held the sea, flying the Christian flag. Renouncing non-intervention on the mainland, they set power above prosperity, and the interest of the State above the welfare and safety of a thousand patrician houses. Wherever there were troubled waters, the fisher was Venice. All down the Eastern coast, and along the Alpine slopes to the passes which were the trade route to Northern Europe, and still farther, at the expense of Milan and Naples, the patriarch of Aquileia and the Duke of Ferrara, the Emperor and the Pope, the Queen of the Adriatic extended her intelligent sway. It was under the long administration of the Doge Foscari, Byron's hero, that it dawned upon the Venetians that it might be their mission to supersede the frail and helpless governments of the Peninsula; and their famous politician and historian, Paruta, believed that it was in their power to do what Rome had done. Their ambition was evident to their neighbours, and those whom they had despoiled, under every plausible pretext, awaited the opportunity of retribution.

Julius, taking counsel with Machiavelli, found it easy to form a league composed of their enemies. As it was not the interest of the empire, France and Spain, to spite Venice by strengthening each other, the Venetians imagined they could safely hold their ground, leaving the dependent cities to make their own terms with the enemy. Padua held out victoriously against Maximilian, but the battle of Agnadello was lost against the French in the same year 1509, in which, fighting under the Crescent in the Indian Ocean, the Venetians were defeated by the Portuguese, and lost their Eastern trade. They soon obtained their revenge. Having gained his ends by employing France against Venice in the League of Cambray, Julius now allied himself with the Venetians to expel the French from Milan. He had recovered the papal possessions, he had broken the Venetian power, and in this his third effort to reconstitute Italy, he still succeeded, because he had the support of the Venetians and the Swiss. The French gave battle to the Spaniards at Ravenna and to the Swiss at Novara, and then they evacuated the Milanese.

Lewis XII swore that he would wreak vengeance on the papacy, and, in conjunction with the Emperor, opened a Council at Pisa, which was attended by a minority of cardinals. Julius met the attack by calling a general Council to meet at the Lateran, which was the first since the great reforming Council, and was still sitting when Julius died in 1513. Like the Council at Pisa, it was regarded at Rome as a move in the great game of Politics, and it made no serious attempt to heal the longstanding and acknowledged wounds of the Church. Its action spread the belief that the reigning diseases were known, but that the remedy was refused, and that reforms that might help religion were not to be expected from Church or State. Julius II died without having expelled the barbarians, as he had promised. The French were gone, but the Spaniards remained unshaken, and were still the pivot of the operations of the Holy See. The investiture of Naples was granted to Ferdinand of Aragon, and the fairest region in Europe bound Spain irrevocably to the Popes.

Although the Italian scheme of Julius was left half-way, his Roman scheme was completed; the intermittent suzerainty of the Middle Ages was straightened out into effective sovereignty over the half of Central Italy, where anarchy used to reign, and the temporal power was fixed on foundations solid enough to bear the coming diminution of spiritual power. The added splendours of modern royalty, round which cardinals of reigning houses—Medici, Este, Famese, Gonzaga—displayed the pomp and ceremony of semi-regal state, in palaces built by Bramante and Michael Angelo, with the ambassadors and protectors of the Powers, and the heads of princely families that had worn the tiara, made Rome the magnetic pole of aristocratic society. As the capital of an absolute monarchy, as others were, it became associated with principles which, in the Middle Ages, it resisted with spiritual and secular weapons; and the magnitude of the change was apparent when Leo X, by the Concordat of Bologna, conceded to Francis I the choice of bishops and the higher patronage of the Church of France. For Francis on his accession sent an army into Italy, the last work of Julius II was overthrown at Marignano, and France again was master of the Milanese.

The final struggle was to come at the vacancy of the Imperial throne. Ferdinand of Aragon was dead, and Naples passed to the King of undivided Spain. It was the unswerving policy of Rome that it should not be united with the Empire, and against that fixed axiom the strongest dynasty of emperors went to pieces. The Reformation had just begun in Germany, and Leo wished one of the Northern Electors to be chosen as Maximilian's successor. In conformity with the political situation, he would have preferred Frederic of Saxony, the protector of Luther. The election of Charles, in 1519, was a defiance of the Balance of Power, a thing not to the taste of the Middle Ages, but becoming familiar in those days. France, unable formerly to keep Naples against Spain, had now to defend Lombardy against Spain, supported by Germany, Naples, and the Netherlands. Francis maintained the unequal struggle for four years, although his most powerful vassal, Bourbon, brought the enemy to the gates of Marseilles. The decisive action of the long Italian war was fought at Pavia in June 1525, where Francis was taken prisoner, and was compelled to purchase his release by cruel sacrifices.