II. The means of preventing the different forms of disease that have been mentioned, come next under our consideration.

Happily for mankind, Heaven has kindly sent certain premonitory signs of the most fatal of them. These signs appear,

I. Externally, in certain changes in previous diseases, in the atmosphere, and in the animal and vegetable creation.

II. In the human body.

1. The first external premonitory sign that I shall mention is, an unusual degree of violence in the diseases of the previous year or season. Many proofs of the truth of this remark are to be met with in the works of Dr. Sydenham. It has been confirmed in Philadelphia, in nearly all her malignant fevers since the year 1793. It would seem as if great and mortal epidemics, like the planets, had satellites revolving round them, for they are not only preceded, but accompanied and followed, by diseases which appear to reflect back upon them some of their malignity. But there is an exception to this remark, for we now and then observe uncommon and general healthiness, before the appearance of a malignant epidemic. This was the case in Philadelphia, previously to the fevers of 1798 and 1799. I have ascribed this to the stimulus of the pestilential miasmata barely overcoming the action of weak diseases, without being powerful enough to excite a malignant fever.

2. Substances, painted with white lead, and exposed to the air, suddenly assuming a dark colour; and winds from unusual quarters, and unusual and long protracted calms, indicate the approach of a pestilential disease. The south winds have blown upon the city of Philadelphia, ever since 1793, more constantly than in former years. A smokiness or mist in the air, the late Dr. Matthew Wilson has remarked, generally precedes a sickly autumn in the state of Delaware.

3. Malignant and mortal epidemics are often preceded by uncommon sickness and mortality among certain birds and beasts. They have both appeared, chiefly among wild pigeons and cats in the United States. The mortality among cats, previous to the appearance of epidemics, has been taken notice of in other countries. Dr. Willan says it occurred in the city of London, between the 20th of March and the 20th of April, in the year 1797, before a sickly season, and Dr. Buneiva says it preceded a mortal epidemic in Paris. The cats, the doctor remarks, lose, on the second day of their disease, the power of emitting electrical sparks from their backs, and, when thrown from a height, do not, as in health, fall upon their feet[13].

4. The common house fly has nearly disappeared from our cities, moschetoes have been multiplied, and several new insects have appeared, just before the prevalence of our late malignant epidemics.

5. Certain trees have emitted an unusual smell; the leaves of others have fallen prematurely; summer fruits have been less in size, and of an inferior quality; and apples and pears have been knotty, in the summers previous to several of our malignant autumnal fevers. Dr. Ambrose Parey says, an unusually rapid growth of mushrooms once preceded the plague in Paris.

II. The premonitory signs of an approaching malignant epidemic in the human body are,