| Nitrous Oxide | |
| Joseph Priestley | 1776 |
| Humphry Davy | 1800 |
| Horace Wells (Colton, Riggs, Evans, Best) | 1844 |
| Alcohol | |
| Collier | 1835–42 |
| Ether | |
| Michael Faraday | 1818 |
| W. E. Clarke | 1839 |
| Crawford W. Long | 1842 |
| E. E. Marcy | 1844 |
| W. T. G. Morton | 1846 |
| Charles T. Jackson | 1846 |
| First surgical operation in America | October 16, 1846 |
| First surgical operation in Great Britain | December 21, 1846 |
| (Warren, Hayward, Bigelow, Boote, Robinson, Liston,Buchanan, Louget, Snow, Simpson, Bernard, Clover) | |
| Chloroform | |
| Guthrie | 1831 |
| Waldie | 1847 |
| James Young Simpson | 1847 |
| First surgical operation under chloroform, in Edinburgh | November 15, 1847 |
| (Soubeiran, Liebig, Dumas, Flourens, M. Duncan,G. Keith, Snow, Nunneley, James Arnott) | |
| Cocaine | |
| Gädeke | 1855 |
| Hughes Bennett | 1874 |
| Von Anrep | 1880 |
| Koller | 1884 |
‘Wellcome’ Brand Chloroform, 1/4 lb. in drop bottle—exact size
‘Wellcome’ Brand Chloroform
Ethyl chloride
‘Wellcome’ Brand Chloroform represents the results of the most recent researches. It embodies the essentials of purity and uniformity, the necessary basis of a satisfactory chloroform. Some chloroforms which satisfy official standards have yet been shown to vary in composition and in effect, the result depending on the occurrence in the preparation of a small and varying quantity of ethyl chloride. ‘Wellcome’ Brand Chloroform is of constant composition and gives uniform effects. Conforms to B.P. It conforms in every respect to the requirements of the B.P., and contains a small and definite proportion of ethyl chloride, which has been found to assist the satisfactory induction of anæsthesia.
‘Wellcome’ Brand Chloroform, 30 c.c., in hermetically-sealed tube. Length of tube, 5-1/4 in.
Proved value
‘Wellcome’ Brand Chloroform is the result of prolonged laboratory experiment and careful clinical observation. Its reception by the profession verifies the theory upon which its production is based. It has been largely used in hospital and in private practice, and with gratifying results. Reports from most experienced anæsthetists agree in regarding ‘Wellcome’ Brand Chloroform as a distinct advance. Its constancy in composition gives confidence in administration, and its freedom from irritating and Confidence in administration depressant principles removes the source of many of the accidents which have hitherto been regarded as grave objections to the employment of chloroform as an anæsthetic.