On the evening of January 7, 1898, Mrs. Holmes retired to bed, apparently in her usual health, about half-past nine. The only other persons in the house were her daughter Annie, her son Percy, and her infant. The daughter noticed that her mother took a glass of water upstairs with her, which was an unusual circumstance. On going to her mother's bedroom shortly afterwards, she found her suffering great pain, and she saw the glass, now almost empty, standing on a chest of drawers.

Percy Holmes ran out and called in the assistance of some neighbours, and then went for a doctor. When medical aid arrived, the unfortunate woman was in convulsions and died shortly afterwards.

The day after her death the police searched the house, but failed to find any trace of poison, and an inquest was held on January 8, which Horsford was summoned to attend.

In his evidence before the coroner, he swore that he had neither written to nor seen the deceased woman. The medical evidence proved that death was caused by strychnine.

The inquest was adjourned for a week, and in the meanwhile Mrs. Holmes was buried. From information received by the police, a further search was made in the house, with the result that two packets were discovered under the feather bed in Mrs. Holmes' bedroom. One packet of buff-coloured paper was found to contain about thirty-three grains of strychnine in powder, on which was written the words, "One dose. Take as told," in Horsford's handwriting. On the second packet, the contents of which had been used, was written, "Take in a little water. It is quite harmless." This was also in Horsford's handwriting.

On January 10, Walter Horsford was arrested on the charge of perjury committed at the inquest, and it was resolved to have another examination made of the body of the deceased woman. On examination of further documents and letters discovered by the police, the charge of wilful murder was added to corrupt perjury against Horsford, and he was committed for trial.

The trial took place on June 2, 1898, at Huntingdon, before Mr. Justice Hawkins.

Dr. Stevenson stated in his evidence, he first made an analysis of a portion of the body of Mrs. Holmes on January 19, and extracted 1·31 grain of strychnine, but no other poison. Subsequently he examined the two packets discovered under the bed, and found one contained 33¾ grains of powdered strychnine, and the other, which presented the appearance of having had the powder shaken out, a few minute crystals of strychnine. In each case it was the pure alkaloid. The body was exhumed nineteen days after death, and he then made an analysis of all the chief organs, and obtained therefrom a total quantity of 3·69 grains of strychnine. Death usually occurred about half an hour after the commencement of the symptoms. He judged there could not have been less than ten grains of strychnine in the body at the time of death.

The jury found Walter Horsford guilty, and he was sentenced to death.