4.—Statement of Dr. Marsden

My name is Anthony Marsden. I am a physician, and formerly resided at Mrs. Brown's house, in Russell Place. Some three or four years ago I found the atmosphere of London beginning to tell upon my health, and determined to remove into the suburbs. I bought a small practice in the neighbourhood of St. John's Wood, and gave up the greater portion of my London patients. I was, however, desirous of not altogether relinquishing that connection, and with this object rented two rooms at Mrs. Brown's, where I might be consulted by such patients as I still retained in that neighbourhood. I used to drive up for this purpose every Monday and Thursday morning. I had been doing this for some time, when the first and second floor apartments were taken by the Baron R**. I did not at first much like him. I thought him an impostor. He seemed, however, to wish to make my acquaintance, and I found that he was, at all events, a very highly informed man on all matters of science. We had frequent conversations respecting mesmerism. He certainly seemed to be himself a believer in it. Were I not myself thoroughly satisfied of its impossibility, I am not at all sure but that he might have convinced me on the subject. I am quite unable to account for many of the phenomena exhibited. They were, however, of course, to be accounted for in some way. He seemed a very excellent chemist, and we used at times to pursue our investigations together. There was a small room at the back of the house, on the basement floor, which he used as a laboratory. He invited me to make use of it, and I was frequently there. He was always engaged in experiments of one kind or another, and had various ingenious projects in hand. In the laboratory was a large assortment of chemicals and medicines of various kinds. In the case of poor patients, I have sometimes asked him to make up a prescription, and he has done so. At the time at which I knew him, he was engaged in a series of experiments on the metals, and more especially on mercury, antimony, lead, and zinc. I think he must have had almost every preparation of these that is made. I believe that his researches were for the purpose of finding a specific against the disease so prevalent among painters, which is known by the name of "lead colic." The laboratory was at the back of the house, and quite detached from all the other rooms. There was an open space between it and the rest of the house, with only a passage communicating with the offices. This passage was shut off by a glass door, and there was a wooden door at the end into the laboratory. Both these doors were always kept closed. They were not usually locked. I told the Baron I thought they should be, but he said no one would go there. He had a weight put on to the laboratory door to close it. The glass door had a spring already. I frequently made use of his laboratory: sometimes when he was absent. I might go there with or without him, whenever I pleased. There was no attempt at concealing from me anything whatever that was done there. It was all quite open. I attended Madame R** through greater part of her illness. It was a very long affair, and of a very singular character. I cannot be at all certain as to the date at which it commenced. I was not regularly called in at the time, and did not notice it in my book. The Baron only consulted me in a friendly way about it, two or three days afterwards. It was certainly as much as that. I think it was the third day. I cannot be sure of that, but I am quite sure it was at least the second. By being the second day, I mean that at least one clear day had intervened between the night on which she was ill and the day on which I was consulted by the Baron. I cannot swear to more than one, but I think it must have been. From what the Baron told me of the symptoms, I remember concluding it to be a case of English cholera, but she was almost recovered at the time I first heard of it, and I did not prescribe for her. About a fortnight or three weeks after this she had another slight attack, for which the Baron himself also prescribed. He acquainted me on my visit to town with the course he had pursued, and I entirely concurred in his treatment of the case. The attack, however, returned, I think more than once, and he then asked me to see and prescribe for her. I first saw her professionally on the 23rd of May, 1856.[4] This was two days after the third or fourth attack, which occurred on the night of the 21st of May. As soon as I regularly took up her case, I made notes of it in my diary. Extracts from this are inclosed (vide 5 herewith), showing the progress of the case from time to time. I attended her throughout her illness. The attacks occurred, as will be seen from my diary, about every fortnight. They increased in intensity up to the 10th of October, 1856. At this time she was apparently, for three or four days, almost in articulo mortis, and I was unable to hold out any hope of her recovery. Another attack would certainly have been fatal. Happily the disease appeared to have spent itself, and at the expiration of the fortnight no renewal of the more acute symptoms was experienced. From this date Madame R** progressed steadily but slowly to convalescence, and would no doubt have ultimately entirely recovered, but for the unfortunate accident which put an end to her life. Madame R**'s case was one of great difficulty. It was apparently one of chronic gastritis; but its recurrence in an acute form at stated intervals was a very abnormal incident. The case presented, in fact, all the more prominent features of that of chronic antimonial poisoning recorded by Dr. Mayerhofer in Heller's Archiv., 1846, and alluded to by Professor Taylor in his work on Poisons, p. 539. There were also strong points of general resemblance to the other cases of McMullen and Hardman, quoted by Professor Taylor at the same page, and recorded in Guy's Hospital Reports for October, 1857. As matters progressed, I took the opportunity of pointing this out as delicately as I could to the Baron, and asked if he had any suspicions of foul play. He seemed at first almost amused by the suggestion; but upon further consultation was inclined to take a graver view of the matter. We went carefully through the cases in question, the Baron translating that of Dr. Mayerhofer for my benefit, as I was not a German scholar. At his suggestion, we determined to analyse the various excretions, &c., and an examination was accordingly instituted in the Baron's laboratory. He was always very particular in keeping up the supply of medicine, and would never allow the bottles, &c., to be thrown away. There was therefore some remnant of every medicine that had been made up for her. These we tested carefully, as well as the excreta, &c., both for arsenic and for antimony, but without finding the slightest trace of either. The analysis was conducted by the Baron, who took the greatest interest in it. I could not, perhaps, have done it myself. Such matters have not come within my line of practice. In such a case I should certainly not trust to my own manipulations. I trusted to those of the Baron, because I knew him to be an expert practical chemist, and in the daily habit of such operations. My own share in them was limited to the observation of results, and their comparison with those pointed out by Professor Taylor. I did not take any special pains to ascertain the purity of the chemical tests employed or of their being in fact what they were assumed to be. That is to say, when a colourless liquid with all the apparent characteristics of nitric acid was taken from a bottle labelled "Nit. Ac." I took for granted that nitric acid was being employed. Similarly, of course, with the other chemical agents. It never occurred to me to do otherwise. Nor did I take any especial precautions to identify the matters examined. Others might certainly have been substituted; but if so, it must have been done by the Baron himself. It was, perhaps, possible that he might have conducted his investigations, under such supervision as I then exercised, with fictitious tests, and it was quite so to substitute other matters and mislead me by subjecting them to a real analysis. That is to say, this would have been possible to be done by the Baron. No one else could, under the circumstances, have done it, or at least without his direct connivance. I had no ground for any suspicion of the kind, nor do I see any now. I think it most unwarrantable. Every circumstance that came under my notice goes equally to contravene such a supposition. The Baron was devotedly attached to his wife: he supplied her liberally with professional advice, as also with nurses, medicine, and every necessary; his care for her led him to precautions which, in their incidental results, must have inevitably exposed any attempt at the administration of poison. During the severer period of the disorder, he had no opportunity of attempting such a crime, as he universally insisted on both food and medicine being both prepared and administered by the nurses; he himself rendered every assistance in the endeavour to detect any such attempt when its possibility had been suggested by myself; and lastly, Madame R** did not die, although the investigation had already removed all suspicion. I think such an imputation wholly unwarranted and unwarrantable from any one circumstance of the case.

5.—Extracts from Dr. Marsden's Diary[5]

MAY 23rd.—Madame R**, nausea, vomiting, tendency to diarrhoea, profuse perspiration, and general debility. Pulse low, 100. Spirits depressed. Burning pain in stomach—abdomen tender on pressure. Tongue discoloured.

26th.—Madame R** slightly better—less nausea and pain.

30th.—Madame R**. Improvement continues.

JUNE 2nd.—Madame R** improving.

6th.—Ditto.

9th.—Recurrence of symptoms on Saturday evening.[6] Increased nausea, vomited matter yellow with bile. Pulse low, 105. Throat sore, and slight constriction. Tongue foul.

13th.—Symptoms slightly ameliorated. Treatment continued.