The Duke further informs us that the dose was duly administered; but that Gennaro, fortunately for himself, ate nothing for dinner that day but cabbage dressed with oil, which acting as an antidote, caused him to vomit profusely, and saved his life. He was exceedingly ill for five days, but never suspected that he had been poisoned.

In process of time, poison vending became a profitable trade. Eleven years after this period, it was carried on at Rome to such an extent that the sluggish government was roused to interference. Beckmann, in his "History of Inventions," and Lebret, in his "Magazin zum Gebrauche der Staaten Kirche Geschichte," or Magazine of Materials for a History of a State Church, relates that, in the year 1659, it was made known to Pope Alexander VII. that great numbers of young women had avowed in the confessional that they had poisoned their husbands with slow poisons. The Catholic clergy, who in general hold the secrets of the confessional so sacred, were shocked and alarmed at the extraordinary prevalence of the crime. Although they refrained from revealing the names of the penitents, they conceived themselves bound to apprise the head of the church of the enormities that were practised. It was also the subject of general conversation in Rome that young widows were unusually abundant. It was remarked, too, that if any couple lived unhappily together, the husband soon took ill and died. The papal authorities, when once they began to inquire, soon learned that a society of young wives had been formed, and met nightly, for some mysterious purpose, at the house of an old woman named Hieronyma Spara. This hag was a reputed witch and fortune-teller, and acted as president of the young viragos, several of whom, it was afterwards ascertained, belonged to the first families of Rome.

In order to have positive evidence of the practices of this female conclave, a lady was employed by the Government to seek an interview with them. She dressed herself out in the most magnificent style; and having been amply provided with money, she found but little difficulty, when she had stated her object, of procuring an audience of La Spara and her sisterhood. She pretended to be in extreme distress of mind on account of the infidelities and ill-treatment of her husband, and implored La Spara to furnish her with a few drops of the wonderful elixir, the efficacy of which in sending cruel husbands to "their last long sleep" was so much vaunted by the ladies of Rome. La Spara fell into the snare, and sold her some of her "drops," at a price commensurate with the supposed wealth of the purchaser.

The liquor thus obtained was subjected to an analysis, and found to be, as was suspected, a slow poison—clear, tasteless, and limpid, like that spoken of by the Duke of Guise. Upon this evidence the house was surrounded by the police, and La Spara and her companions taken into custody. La Spara, who is described as having been a little, ugly, old woman, was put to the torture, but obstinately refused to confess her guilt. Another of the women, named La Gratiosa, had less firmness, and laid bare all the secrets of the infernal sisterhood. Taking a confession, extorted by anguish on the rack, at its true value (nothing at all), there is still sufficient evidence to warrant posterity in the belief of their guilt. They were found guilty, and condemned, according to their degrees of culpability, to various punishments. La Spara, Gratiosa, and three young women, who had poisoned their husbands, were hanged together at Rome. Upwards of thirty women were whipped publicly through the streets; and several, whose high rank screened them from more degrading punishment, were banished from the country, and mulcted in heavy fines. In a few months afterwards, nine women more were hanged for poisoning; and another bevy, including many young and beautiful girls, were whipped half naked through the streets of Rome.

This severity did not put a stop to the practice, and jealous women and avaricious men, anxious to step into the inheritance of fathers, uncles, or brothers, resorted to poison. As it was quite free from taste, colour, and smell, it was administered without exciting suspicion. The skilful vendors compounded it of different degrees of strength, so that the poisoners had only to say whether they wanted their victims to die in a week, a month, or six months, and they were suited with corresponding doses. The vendors were chiefly women, of whom the most celebrated was a hag, named Tophania, who was in this way accessory to the death of upwards of six hundred persons. This woman appears to have been a dealer in poisons from her girlhood, and resided first at Palermo and then at Naples. That entertaining traveller, Father Lebat, has given, in his Letters from Italy, many curious particulars relating to her. When he was at Civita Vecchia, in 1719, the Viceroy of Naples discovered that poison was extensively sold in the latter city, and that it went by the name of aqueta, or little-water. On making further inquiry, he ascertained that Tophania (who was by this time near seventy years of age, and who seems to have begun her evil courses very soon after the execution of La Spara) sent large quantities of it to all parts of Italy in small vials, with the inscription "Manna of St. Nicholas of Barri."

The tomb of St. Nicholas of Barri was celebrated throughout Italy. A miraculous oil was said to ooze from it, which cured nearly all the maladies that flesh is heir to, provided the recipient made use of it with the due degree of faith. La Tophania artfully gave this name to her poison to elude the vigilance of the custom-house officers, who, in common with everybody else, had a pious respect for St. Nicholas de Barri and his wonderful oil.

The poison was similar to that manufactured by La Spara. Hahnemann the physician, and father of the homoepathic doctrine, writing upon this subject, says it was compounded of arsenical neutral salts, occasioning in the victim a gradual loss of appetite, faintness, gnawing pains in the stomach, loss of strength, and wasting of the lungs. The Abbe Gagliardi says that a few drops of it were generally poured into tea, chocolate, or soup, and its effects were slow, and almost imperceptible. Garelli, physician to the Emperor of Austria, in a letter to Hoffmann, says it was crystallized arsenic, dissolved in a large quantity of water by decoction, with the addition (for some unexplained purpose) of the herb cymbalaria. The Neapolitans called it Aqua Toffnina; and it became notorious all over Europe under the name of Aqua Tophania.

Although this woman carried on her infamous traffic so extensively, it was extremely difficult to meet with her. She lived in continual dread of discovery. She constantly changed her name and residence; and pretending to be a person of great godliness, resided in monasteries for months together. Whenever she was more than usually apprehensive of detection, she sought ecclesiastical protection. She was soon apprised of the search made for her by the Viceroy of Naples, and, according to her practice, took refuge in a monastery. Either the search after her was not very rigid, or her measures were exceedingly well taken; for she contrived to elude the vigilance of the authorities for several years. What is still more extraordinary, as showing the ramifications of her system, her trade was still carried on to as great an extent as before. Lebat informs us that she had so great a sympathy for poor wives who hated their husbands and wanted to get rid of them, but could not afford to buy her wonderful aqua, that she made them presents of it.

She was not allowed, however, to play at this game for ever; she was at length discovered in a nunnery, and her retreat cut off. The Viceroy made several representations to the superior to deliver her up, but without effect. The abbess, supported by the archbishop of the diocese, constantly refused. The public curiosity was in consequence so much excited at the additional importance thus thrust upon the criminal, that thousands of persons visited the nunnery in order to catch a glimpse of her.

The patience of the Viceroy appears to have been exhausted by these delays. Being a man of sense, and not a very zealous Catholic, he determined that even the Church should not shield a criminal so atrocious. Setting the privileges of the nunnery at defiance, he sent a troop of soldiers, who broke over the walls and carried her away vi et armis. The Archbishop, Cardinal Pignatelli, was highly indignant, and threatened to excommunicate and lay the whole city under interdict. All the inferior clergy, animated by the esprit du corps, took up the question, and so worked upon the superstitious and bigoted people, that they were ready to rise in a mass to storm the palace of the Viceroy and rescue the prisoner.