The requirements of the several pharmacopeias differ somewhat and the specific gravity as given is as follows:
| U. S. P. VIII, 1905 | 0. | 870 | to 0.940 | at 25° |
| Ph. Brit. IV, 1895 | 0. | 885 | to 0.890 | at 15.5° |
| B. P. C. II, 1911, usually | 0. | 875 | or lower | at 15° |
| Ph. Germ. V, 1910, at least | 0. | 885 | at 15° | |
| Ph. Ross. VI, 1910 | 0. | 880 | to 0.885 | at 15° |
| Ph. Hung. III, 1909 | 0. | 88 | to 0.89 | at 15° |
| Ph. Ital. III, 1909 | 0. | 875 | to 0.890 | at 15° |
| Ph. Fr. V, 1908, about | 0. | 875 | at 15° | |
| Ph. Serb. II, 1908, about | 0. | 880 | at 15° | |
| Ph. Svec. IX, 1908 | 0. | 88 | to 0.90 | at 15° |
| Ph. Helv. IV, 1907 | 0. | 880 | to 0.885 | at 15° |
| Ph. Dan. VII, 1907, at least | 0. | 880 | at 15° | |
| Ph. Austr. VIII, 1906, at least | 0. | 880 | at 15° | |
| Ph. Belg. III, 1906, not below | 0. | 880 | at 15° | |
| Ph. Japon. III, 1906 | 0. | 875 | to 0.945 | at 15° |
| Ph. Ndl. IV, 1905, not below | 0. | 860 | at 15° | |
| Ph. Hisp. VII, 1905 | 0. | 840 | at 15° |
For pharmaceutical purposes, liquid petrolatum may be divided into two grades, the lighter or more limpid oil, used extensively as a vehicle for oil sprays, and the heavier, more viscid oil generally recognized in European pharmacopeias and used as an ingredient of ointments and more recently as a remedy in the treatment of intestinal stasis.
Under petrolatum liquidum the U. S. P. recognizes a mixture of hydrocarbons, chiefly of the methane series, which occurs as a colorless or very slightly yellowish, oily, transparent liquid without odor or taste and having a specific gravity of about 0.870 to 0.940 at 25 C. For the U. S. P. IX, it is proposed to change this requirement somewhat so as to have it apply to a transparent liquid free from fluorescence, without odor or taste and having a specific gravity of from 0.845 to 0.940 at 25 C.
Such a requirement would include all of the available paraffin oils irrespective of origin. The now commonly available commercial liquid petrolatum, used for pharmaceutical purposes, is practically colorless and all of the better grades are free from odor or taste. The specific gravity varies from 0.855 to 0.895. The lighter oils, having a specific gravity of from 0.860 to 0.870, are usually preferred in the making of oil sprays or solutions of substances to be used as local applications. The product having a specific gravity above 0.875 evidently contains a considerable amount of dissolved solid paraffin which separates out at temperatures at or below 0 C., but readily dissolves again at temperatures above 10 C.
There is considerable difference in the chemical composition of the paraffin oils obtained from various sources. The American oil consists largely of hydrocarbons of the methane series, while the Russian oil contains naphthenes or hydrocarbons of the benzene series, having the empirical composition of ethylene, (CnH2n) which may be considered as hydrogenated aromatic hydrocarbons, though they behave with reagents very much in the same way as do the hydrocarbons of the methane series.
Mineral oils with a naphthene base are best suited for making white petrolatum, and at the present time the production of the colorless water-white liquid petrolatum appears to be confined largely or almost exclusively to the crude product of the Baku district of Russia, though it is asserted that it is now also made from the Hanover (Germany) crude oil and that some is being produced by “cracking” the white solid paraffin.
It is also said that the American oil can be made water white but that it is not being so produced at present for economic reasons; the yellowish oil, free from fluorescence, having a very wide sale, both as a lubricant and as a substitute for lard oil and other of the more costly lubricating oils.
From a pharmaceutical point of view it would appear important to note the physical characteristics of the oil and to insist on absence of color, absence of odor and taste, absence of acid and of alkali and a specific gravity in harmony with the purposes for which the oil is to be used.
During the past year or two liquid petrolatum has attracted considerable attention as a remedy in the treatment of intestinal stasis or chronic constipation, the practice of using it having been developed largely through its recommendation by Sir W. Arbuthnot Lane and his associates. This use of liquid petrolatum and of petrolatum products generally is by no means novel. N. A. Randolph[70] of Philadelphia was among the first to suggest its use for this purpose in an article published in 1885. Randolph also appears to have been the first to experiment with petrolatum and to determine its non-absorbability from the intestinal tract. In an article[71] in 1884 he concludes that “pure petrolatum while entirely unirritating to the digestive tract is valueless as a foodstuff.”