“From examination it is concluded that Midol depends essentially on pyramidon for its therapeutic effect.”
Pyramidon is a proprietary preparation derived from, and having the antipyretic and anodyne properties of, antipyrin. While some observers have asserted that it is more likely to cause collapse than are either antipyrin or acetphenetidin there is no positive evidence of this assertion. That the use of pyramidon has been until recently practically restricted to physicians may account for the fact that its toxic effects are not as well known as are those of antipyrin, acetphenetidin, acetanilid, etc., which for some years have been indiscriminately used by the public. As the use of pyramidon as a “patent medicine” now bids fair to become as general as the better known antipyretics, it is probable that its toxicology will become better known.
It is interesting to note that pyramidon in the form of Midol is put on the American market by the General Drug Company, which also acts as a distributor of salvarsan (“606”). The General Drug Company is said to have for its president, W. M. Hoge, who was formerly employed in the comptroller’s office during the administration of Herman A. Metz, and the latter being employed by the Consolidated Color and Chemical Works and being president of Victor Koechl & Co. The General Drug Company, in its price list to physicians, lists the “ethical proprietary” pyramidon, but contains no mention of its “patent medicine” Midol.
NURITO
Midol is not the only “patent medicine” in which pyramidon is the essential drug. Nurito, which is advertised as “not a patent medicine but a proprietary preparation,” is a nostrum put on the market by the Magistral Chemical Co., New York. Here are some of the claims:
“Only U. S. P. ingredients are used in Nurito.”
“Guaranteed to relieve or your money refunded, Rheumatism, Sciatica, Neuritis.”
“There is no compound known in medicine that so rationally, scientifically and effectively removes waste and poisons from the human system as Nurito.”
The Association’s laboratory recently analyzed a specimen of Nurito. The report follows:
A dollar-size package of Nurito was purchased and found to contain seven powders. The powders ranged in weight from 9 to 12 grains, the average weight being nearly 11 grains. The presence of pyramidon, phenolphthalein and milk sugar was demonstrated. Alkaloids, acetanilid, acetphenetidin, chlorids, bromids, iodids, heavy metals, starch and sulphates were absent. Quantitative examination indicated that the composition of Nurito is essentially as follows: