Hagee’s Cordial of the Extract of Cod Liver Oil, Compound.—“Tonic, stimulant, alterative, reconstructive, nutritive and digestive.” “Each fluid ounce represents the extract obtainable from 1⁄3 fluid ounce of cod liver oil (the fatty portion being eliminated), 6 grs. calcium hypophosphite, 3 grs. sodium hypophosphite, 1⁄2 gr. salicylic acid (made from oil wintergreen), with glycerin and aromatics.”
Vinol.—“The modern tonic reconstructor containing the medicinal extractives of fresh cod livers with peptonate of iron.” “When the blood is poor, when more fresh blood is needed, when the weak need strength, when the throat and lungs are affected, TAKE VINOL.”
Wampole’s Perfected and Tasteless Preparation of an Extract of Cod Liver.—“Contains a solution of an extractive obtainable from fresh cod livers, the oily or fatty portion being afterward eliminated. This extractive is combined with liquid extract of malt, fluid extract of wild cherry and compound syrup of hypophosphites (containing calcium, sodium, potassium, iron, manganese, quinine and strychnine).”
Waterbury’s Compound, Plain.—“Made from cod liver oil, digestive ferments, malt extract unfermented, hypophosphites comp. special, ext. cherry, eucalyptus, aromatics, etc.”
Thus we have represented in our experiments an “extract” with hypophosphites, one with peptonate of iron, one with malt extract and hypophosphites and the alkaloids quinin and strychnin, and one with malt extract and hypophosphites without alkaloids.
In order to prepare a dry ration of suitable keeping properties, it was necessary to remove the alcohol and water from the various preparations. This was done by evaporation under reduced pressure at from 40 to 55 C. (104 to 131 F.). In the case of Hagee’s Cordial it was claimed that one fluidounce of the preparation represented 1⁄3 fluidounce of cod liver oil, and in the subsequent substitution for cod liver oil in our rations, this ratio was used for all four products.... These are very dissimilar preparations, the alcohol ranging from 7.50 to 18.69 per cent., the extract from 8.72 to 39.53 per cent. (10.81 of the 13.18 gm. of extract in Hagee’s Cordial being glycerin), the ash from 0.305 to 1.967 per cent., the reducing sugars from 1.35 to 17.10 per cent., and the glycerin from a trace to 10.81 per cent. Wampole’s contained quinin and strychnin, the others no alkaloids; salicylates were present in all but Wampole’s; saccharin in Hagee’s. The Pettenkoffer test for biliary acids gave a negative result in Hagee’s and Wampole’s; in Vinol and Waterbury’s, small amounts of fatty acids were obtained, amounting to 0.016 and 0.032 gm. per hundred c.c., respectively, quite insignificant amounts.
The feeding experiments were made on albino rats of both sexes, which were placed, when about 6 weeks old, on a standard ration, No. 7, and after several months, when a failure to maintain weight was indicated,[148] an amount of dealcoholized cordial extract equivalent to 18 per cent. of cod liver oil was substituted for a portion of the lard, the cordial extract later being replaced by an equivalent amount of cod liver oil.
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SUMMARY
Table 11 gives a summary of the actual gains of the fifteen rats on the four rations, compared with the gains shown by cod liver oil and those shown by normal rats at the same period of their life history.