[136] Barker and Rowntree (Bull. Johns Hopkins Hospital 29:215, 221 [Oct.] 1918) obtained the following results with eucalyptus oil:
Cat, hypodermic; survived 3 c.c. per kg.; killed by 5.5 c.c. per kg.
Cat, intraperitoneal; killed by 5 c.c. per kg.
Dog, hypodermic; survived 1.3 c.c. per kg.
They quote from Browning that the following doses, c.c. per kilogram, are not fatal: frogs, 0.5; rabbits, 1 to 5; guinea-pigs, 1.
[137] An ampoule labeled as follows: “Coagulen-Ciba, 20 c.c. in sterile solution ready for use. To be shaken. Importé de Suisse. Op. No. 968” was found to measure only 15 c.c. Another ampoule with the same label and Op. No. 9641 contained considerable sediment.
[138] Since the report was sent to the manufacturers, the results have been published. Hanzlik, P. J., and Weidenthal, C. M., Plasma and Blood Clotting Efficiency of Thromboplastic Agents in Vitro and their Stability, J. Pharmacol. and Exper. Therap. 14:157 (October) 1919; Hanzlik, P. J., Karsner, H. T., and Fetterman, J., Anaphylactoid Conditions, J. Pharmacol. and Exper. Therap. 14:189 (Oct.) 1919; Hanzlik, P. J., Karsner, H. T., and Fetterman, F., Anaphylactoid Phenomena from Thromboplastic Agents, J. Pharmacol. and Exper. Therap. 14:229 (Nov.) 1919.
[139] La Coste: Annalen der Chemie (Liebig’s) 208:34.
[140] Castelli, G.: Arch. f. Schiffs- u. Tropen-Hyg. 16:605, 1912.
[141] Nichols, H. J.: Salvarsan and Sodium Cacodylate, J. A. M. A. 56:492 (Feb. 18) 1911.