| No. of Experiment | Material Fed | Rate of Secretion of Pancreatic Juice in C.c. Per Hour | Increase in C.c. | |
| Three Hours Before Feeding | Three Hours After Feeding | |||
| 3 | Secretin slightly acid | 5 | 11 | 6 |
| 5 | Secretin slightly alkaline | 24 | 30 | 6 |
| 4 | Secretin passed through Berkefeld | 18 | 23 | 5 |
| 1 | Secretin exposed to sun for 4 hrs | 16 | 29 | 13 |
| 2 | Extract of colon (rabbit) | 19 | 29 | 10 |
| 3 | Extract of gastric mucosa | 14 | 23 | 9 |
| 3 | Extract of muscle | 8 | 16 | 8 |
| 2 | Mixture of gelatin, peptone and salt | 23 | 33 | 10 |
| 1 | 1 per cent. peptone solution | 6 | 8 | 2 |
| 4 | 0.2 per cent. hydrochloric acid | 13 | 37 | 24 |
| 3 | Milk and bread | 7 | 20 | 13 |
It is possible by large doses of sodium bicarbonate given shortly before the administration of a preparation so to depress the stomach that it does not respond with the usual production of hydrochloric acid. Under these conditions the administration of secretin is uniformly negative, but the administration of hydrochloric acid on the contrary still serves to increase the pancreatic secretion (Table 6).
TABLE 6.—SECRETIN IN EXPERIMENTAL “ACHYLIA GASTRICA”
| Exp. No. | Material Fed | Rate of Secretion of Pancreatic Juice in C.c. Per Hour | |||||||
| Continuous Secretion Before Feeding* | Secretion After Feeding | ||||||||
| First | Second | Third | First | Second | Third | ||||
| 1 |  | 150 c.c. secretin |  | 8.7 | 7.5 | 6.8 | 3.0 | 1.0 | 4.8 |
| 2 | 4.5 | 6.5 | 10.0 | 6.0 | 7.5 | 7.6 | |||
| 3 | 15.6 | 8.1 | 16.0 | 3.9 | 4.9 | 2.9 | |||
| 1 |  | 150 c.c. 4% HCl (diluted to 250 c.c.) |  | 9.8 | 7.0 | 6.0 | 65.1 | 28.0 | 7.1 |
| 2 | 17.4 | 18.5 | 17.0 | 34.0 | 18.0 | 20.0 | |||
* Five gm. Na HCO3 given at beginning of each first two hours.
COMMERCIAL PREPARATIONS OF SECRETIN
Secretogen and Elixir Secretogen.—The Carnrick Company offers Secretogen[90] for use in a large number of conditions. The following indications for the use of the preparation purport to be based on clinical tests covering a period of several years: dyspepsia, and the indigestions generally, fermentative disorders, gastric catarrh, flatulence, nausea; pancreatic insufficiency, intestinal indigestion; gastric secretory deficiencies, apepsia; constipation and hepatic torpor; intestinal stasis; diarrhea; infantile diarrhea, “summer complaint,” marasmus, inanition and malnutrition; gastric atony and dilatation; cholecystitis and gallstones; nephritis, neurasthenia, cachexia and cancer; epilepsy and high blood pressure. Testimonials are presented as to results in most of these conditions.
A quantity of “Secretogen” and “Elixir Secretogen” was bought in the open market, and the preparations were tested on suitably prepared dogs. The tablets were ground, thoroughly macerated with the solvent used (water, normal salt solution, alcohol, or 0.4 per cent. hydrochloric acid), and filtered. If hydrochloric acid was used, the pulverized tablets were boiled with it, in the manner that secretin is made from duodenal mucosa, and the preparations neutralized previous to injection. The injections were made in from 15 to 20 c.c. of the solvent. All the operations were carried on immediately before the experiment, and as rapidly as possible, so as to avoid oxidation. The Elixir Secretogen was injected directly, without dilution.
TABLE 7.—SUMMARY OF TYPICAL EXPERIMENTS SHOWING THE ABSENCE OF SECRETIN IN “SECRETOGEN”AND “ELIXIR SECRETOGEN” EXCEPT IN OCCASIONAL TESTS WHEN ADMINISTERED IN ENORMOUS DOSES