All arrangements having been completed the missionaries left Cape Town on their way to Kuruman, from whence they were to proceed to their respective stations, with the Makololo and the Matabele. Delays, however, intervened; the Boers had attacked some of the Batlapings, and threatened to attack the Kuruman station; the difficulties of the road also prevented some of the party arriving with the others. At last, however, the way was made clear, the opposition of the Boers to the advance of the party was, through the intervention of Sir George Grey, overcome, and on the 7th of July, 1859, the first division started for their far distant destination. This division comprised Mr. Helmore, a veteran who for many years had been stationed at Lekatlong, with his wife and four children, and Mr. and Mrs. Price. There was also a native teacher from Lekatlong, named Tabe, who determined to accompany his old missionary, and the usual staff of native attendants. These were all to proceed to the Makololo. The situation was a grave one. The end of the journey was a point a thousand miles farther into the interior than any of them had ever been, except two native servants, who had accompanied Livingstone on a previous occasion. But they went forward in faith not knowing what lay before them, but trusting all into the hands of Him, without whose knowledge not even a sparrow falls to the ground.

A week later Mr. Thomas and John Moffat with their wives left; they were speedily followed by Robert Moffat and Mr. Sykes. At Sechele's town the two portions of this latter division were united, and thence they journeyed onwards towards the Matabele. Disease broke out among some of their oxen, and, on reaching the first outpost of Moselekatse's people, a messenger was sent forward to the king explaining the state of affairs, and proposing that the oxen of the missionaries should be left in quarantine, and that Moselekatse should supply his own oxen to bring the party to headquarters. This message was sent so as to avoid connecting the advent of the Gospel among these people with that of a pestilence among their herds of cattle; which would inevitably have been the case had the diseased oxen proceeded onwards and infected those belonging to the Matabele.

An answer was returned to the effect that the party were to proceed, and that though the epidemic took effect, they should be held guiltless.

Moffat despatched a second messenger, to say that he had heard the king's words, and in a couple of days would leave; but that he begged the monarch to reflect on the consequences of the epidemic being introduced among his tens of thousands of cattle, and to believe that the mission party felt the most extreme anxiety upon the subject.

They then proceeded forward very slowly for two or three days, when they were met by another messenger, who stated that Moselekatse was gratified with the anxiety expressed for him and his; and that now, fully convinced of his danger, he desired that all their oxen should return, and that warriors were advancing to drag the mission waggons to headquarters.

Every one started with surprise at the strange idea, but soon the warriors came, shields, and spears, and all, also a number of oxen to be slaughtered for food. After some war evolutions, the warriors took the place of the draught oxen, and a start was made. There was many "a strong pull, a long pull, and a pull all together," as the waggons rolled onward; but after ten days' hard struggle and slow progress, it became evident that the men sent were unequal to the task, and the monarch, who for some unknown reason had kept his oxen back, sent them at last to bring the waggons to his camp.

Moselekatse received his old friend with his usual cordiality; but it soon became evident that something was wrong. All kinds of evasions and delays met the request for a spot of ground on which to found a mission station; days, weeks, and months passed, during which the missionaries suffered great hardships; and at last the chief broke up his camp and left them, without oxen to draw their waggons, saying that he would send people to guide them to the spot where they were to settle, and at which place he would join them later on.

His conduct seemed strange, and Moffat began to suspect that he had repented of giving his permission for the missionaries to settle with him. This proved to be the case; the Boer inroads, following as they had done, in several cases, the advent of the missionaries, made him suspicious, and the fears of himself and people having been aroused, the question was in debate as to whether the settlement should be allowed or not.

At last a favourable change took place, the clouds dispersed, and the sky became clear. Oxen were sent to take the missionary waggons forward to Inyati, there to join Moselekatse. All was settled, a spot which looked well for a station was pointed out, each of the new-comers pitched his tent under a tree that he had chosen, until a more solid dwelling should be erected, and the Matabele Mission was fairly established. This was in December, 1859.

The Mission was established, but work had only begun. The first six months of the year 1860 were months of incessant toil to the missionaries at Inyati. Houses had to be built, waggons repaired, and garden ground made ready for cultivation. Early and late, Moffat was to be found at work,—in the saw-pit, at the blacksmith's forge, or exercising his skill at the carpenter's bench; in all ways aiding and encouraging his younger companions. He also endeavoured to gain Moselekatse's consent to the opening of regular communication with the Livingstone expedition on the Zambesi viâ Matabeleland, but the suspicious nature of the monarch foiled this project. The isolation of his country in this direction was so great that, although but a comparatively short distance away, no tidings whatever could be obtained of the other party who, under Mr. Helmore, had gone to the Makololo tribe.