They spent most of the summer and fall wandering around western Arkansas. Many scholars believe they may have traveled up the Arkansas River almost to eastern Oklahoma before going into their 1541-42 winter quarters in a town (Autiamque) once again commandeered from the Indians. Though the weather was severe, the men stayed fairly snug. Their slaves built a strong stockade around the camp and dragged in ample supplies of firewood. Local Indians provided them with buffalo robes to use as overcoats and to sleep on, and showed them how to snare the rabbits that frequented the nearby cornfields.

During the long days inside the stockade, De Soto at last faced up to his situation. He had lost half his force. Not all had died in battle. A few, despairing of seeing the end of the quest, had deserted to live with the Indians, and the number would increase if he persisted in wandering as he had been doing. Of the original 223 horses, only 40 remained, most of them lame for want of shoes. The death of Juan Ortiz that winter deprived him of his best, if very uncertain, means of communication with the Indians. Reluctantly he decided to turn back to Mississippi. There he intended to build two brigantines and, manning them with his most trustworthy men, send one to Havana and one to Pánuco in hope that one would be able to lead reinforcements back to those who would wait for them at the river.

They reached the roily Mississippi somewhere near the mouth of the Arkansas River. By that time a deadly fever, perhaps malaria, was gnawing at De Soto. Knowing death was near and bitterly resenting the arrogant hostility of the Indians with whom he tried to treat in his extremity, he ordered two of his captains to go out with lancers and infantry and make an example of the nearby town of Anilco. Not expecting an attack, for they had not been among those taking the lead in defying the Spaniards, the unarmed townspeople clustered about in curiosity. A wanton butchery followed. “About one hundred men were slain,” wrote Elvas. “Many were allowed to get away badly wounded, that they might strike terror into those who were absent.” Eighty women and children were taken prisoner.

This effigy from a gourd-shaped ceramic vessel was discovered in a burial at Ocmulgee National Monument in central Georgia. De Soto’s expedition passed near this site.

By the time the bloodletting was over, De Soto could not rise from his bed. After confessing his sins and making his will, he named Luis de Moscoso as his successor. On May 21, 1542, he died.

To keep the Indians from knowing the fate of the great Child of the Sun, as he had been describing himself to them, his followers buried him near the entrance to the town and rode horses back and forth to destroy signs of the digging. The Indians were suspicious, however, and so Moscoso had the corpse disinterred, lest the Indians dig it up and mutilate it. A handful of men then stealthily wrapped the body in a shroud, weighted the burden with sand, and in the darkness of the night rowed out onto the river and dumped it overboard.

De Soto’s plan to build boats for bringing in reinforcements died with him. The men’s one desire now was to leave this country that had brought them only misery. But how? Remembering Narváez’s fate, they were reluctant to try to build enough boats to carry them home by sea. Instead they decided to march overland to Pánuco in northern Mexico. They clung to the decision for four months, fighting off Indians when they had to and living off the country as they had been doing ever since the landing at Tampa Bay. Then, as the subtropical growth began to give way to the desert scrub of south central Texas, they encountered, in a village of poor huts, a woman who said, or they thought she said, that she had seen Christians at a place nine days’ travel away and that “she had been in their hands, but had escaped.” Moscoso sent a squad of cavalrymen with her in the direction she indicated, but when she contradicted herself, or they thought she did, they abandoned the quest.

The Spaniards were losing heart. They could not live off this land of semi-nomadic Indians where little maize grew. As winter approached, the idea of travel by sea no longer seemed so forbidding. Wheeling around, they regained the Mississippi in two months of hard travel over the same trails they had come and in December seized, for use as their fourth winter quarters (1542-43), an Indian town (Aminoya) a little upstream of the one which they had destroyed seven months before.