The manner of its coming first to London proves this also, viz., by goods brought over from Holland, and brought thither from the Levant; the first breaking of it out in a house in Long Acre where those goods were carried and first opened; its spreading from that house to other houses by the visible unwary conversing with those who were sick; and the infecting the parish officers who were employed about the persons dead, and the like. These are known authorities for this great foundation point—that it went on and proceeded from person to person and from house to house, and no otherwise. In the first house that was infected there died four persons. A neighbour, hearing the mistress of the first house was sick, went to visit her, and went home and gave the distemper to her family, and died, and all her household. A minister, called to pray with the first sick person in the second house, was said to sicken immediately and die with several more in his house. Then the physicians began to consider, for they did not at first dream of a general contagion. But the physicians being sent to inspect the bodies, they assured the people that it was neither more or less than the plague, with all its terrifying particulars, and that it threatened an universal infection, so many people having already conversed with the sick or distempered, and having, as might be supposed, received infection from them, that it would be impossible to put a stop to it.

Here the opinion of the physicians agreed with my observation afterwards, namely, that the danger was spreading insensibly, for the sick could infect none but those that came within reach of the sick person; but that one man who may have really received the infection and knows it not, but goes abroad and about as a sound person, may give the plague to a thousand people, and they to greater numbers in proportion, and neither the person giving the infection or the persons receiving it know anything of it, and perhaps not feel the effects of it for several days after.

For example, many persons in the time of this visitation never perceived that they were infected till they found to their unspeakable surprise, the tokens come out upon them; after which they seldom lived six hours; for those spots they called the tokens were really gangrene spots, or mortified flesh in small knobs as broad as a little silver penny, and hard as a piece of callus or horn; so that, when the disease was come up to that length, there was nothing could follow but certain death; and yet, as I said, they knew nothing of their being infected, nor found themselves so much as out of order, till those mortal marks were upon them. But everybody must allow that they were infected in a high degree before, And must have been so some time, and consequently their breath, their sweat, their very clothes, were contagious for many days before. This occasioned a vast variety of cases which physicians would have much more opportunity to remember than I; but some came within the compass of my observation or hearing, of which I shall name a few.

A certain citizen who had lived safe and untouched till the month of September, when the weight of the distemper lay more in the city than it had done before, was mighty cheerful, and something too bold (as I think it was) in his talk of how secure he was, how cautious he had been, and how he had never come near any sick body. Says another citizen, a neighbour of his, to him one day, ‘Do not be too confident, Mr—; it is hard to say who is sick and who is well, for we see men alive and well to outward appearance one hour, and dead the next.’ ‘That is true’, says the first man, for he was not a man presumptuously secure, but had escaped a long while—and men, as I said above, especially in the city began to be over-easy upon that score. ‘That is true,’ says he; ‘I do not think myself secure, but I hope I have not been in company with any person that there has been any danger in.’ ‘No?’ says his neighbour. ‘Was not you at the Bull Head Tavern in Gracechurch Street with Mr—the night before last?’ ‘Yes,’ says the first, ‘I was; but there was nobody there that we had any reason to think dangerous.’ Upon which his neighbour said no more, being unwilling to surprise him; but this made him more inquisitive, and as his neighbour appeared backward, he was the more impatient, and in a kind of warmth says he aloud, ‘Why, he is not dead, is he?’ Upon which his neighbour still was silent, but cast up his eyes and said something to himself; at which the first citizen turned pale, and said no more but this, ‘Then I am a dead man too’, and went home immediately and sent for a neighbouring apothecary to give him something preventive, for he had not yet found himself ill; but the apothecary, opening his breast, fetched a sigh, and said no more but this, ‘Look up to God’; and the man died in a few hours.

Now let any man judge from a case like this if it is possible for the regulations of magistrates, either by shutting up the sick or removing them, to stop an infection which spreads itself from man to man even while they are perfectly well and insensible of its approach, and may be so for many days.

It may be proper to ask here how long it may be supposed men might have the seeds of the contagion in them before it discovered itself in this fatal manner, and how long they might go about seemingly whole, and yet be contagious to all those that came near them. I believe the most experienced physicians cannot answer this question directly any more than I can; and something an ordinary observer may take notice of, which may pass their observations. The opinion of physicians abroad seems to be that it may lie dormant in the spirits or in the blood-vessels a very considerable time. Why else do they exact a quarantine of those who came into their harbours and ports from suspected places? Forty days is, one would think, too long for nature to struggle with such an enemy as this, and not conquer it or yield to it. But I could not think, by my own observation, that they can be infected so as to be contagious to others above fifteen or sixteen days at furthest; and on that score it was, that when a house was shut up in the city and any one had died of the plague, but nobody appeared to be ill in the family for sixteen or eighteen days after, they were not so strict but that they would connive at their going privately abroad; nor would people be much afraid of them afterward, but rather think they were fortified the better, having not been vulnerable when the enemy was in their own house; but we sometimes found it had lain much longer concealed.

Upon the foot of all these observations I must say that though Providence seemed to direct my conduct to be otherwise, yet it is my opinion, and I must leave it as a prescription, viz., that the best physic against the plague is to run away from it. I know people encourage themselves by saying God is able to keep us in the midst of danger, and able to overtake us when we think ourselves out of danger; and this kept thousands in the town whose carcases went into the great pits by cartloads, and who, if they had fled from the danger, had, I believe, been safe from the disaster; at least ‘tis probable they had been safe.

And were this very fundamental only duly considered by the people on any future occasion of this or the like nature, I am persuaded it would put them upon quite different measures for managing the people from those that they took in 1665, or than any that have been taken abroad that I have heard of. In a word, they would consider of separating the people into smaller bodies, and removing them in time farther from one another—and not let such a contagion as this, which is indeed chiefly dangerous to collected bodies of people, find a million of people in a body together, as was very near the case before, and would certainly be the case if it should ever appear again.

The plague, like a great fire, if a few houses only are contiguous where it happens, can only burn a few houses; or if it begins in a single, or, as we call it, a lone house, can only burn that lone house where it begins. But if it begins in a close-built town or city and gets a head, there its fury increases: it rages over the whole place, and consumes all it can reach.

I could propose many schemes on the foot of which the government of this city, if ever they should be under the apprehensions of such another enemy (God forbid they should), might ease themselves of the greatest part of the dangerous people that belong to them; I mean such as the begging, starving, labouring poor, and among them chiefly those who, in case of a siege, are called the useless mouths; who being then prudently and to their own advantage disposed of, and the wealthy inhabitants disposing of themselves and of their servants and children, the city and its adjacent parts would be so effectually evacuated that there would not be above a tenth part of its people left together for the disease to take hold upon. But suppose them to be a fifth part, and that two hundred and fifty thousand people were left: and if it did seize upon them, they would, by their living so much at large, be much better prepared to defend themselves against the infection, and be less liable to the effects of it than if the same number of people lived dose together in one smaller city such as Dublin or Amsterdam or the like.