My dear Brother,

I am much concerned that I was obliged to send off my letter yesterday evening, and the rather as there will be no opportunity of sending this till to-morrow. I find that there was not the least foundation for any part of the reports which I mentioned to you.

Pitt came back last night. He said the physicians do not apprehend present danger, but that their fear is that the insanity will be permanent, but they will not pronounce anything yet. The Prince had a long conversation with him relating to the King's situation, but nothing from which he could collect what he thought of doing in the two cases that may arise. The general notion is, that he will try to negotiate with Pitt from the fear of his popularity; but I do not think it probable. He treated Pitt with civility, but nothing more.

MR. W. W. GRENVILLE TO THE MARQUIS OF BUCKINGHAM.

Sunday, Nov. 9th, 1788.

My dear Brother,

There was no truth in any of the reports which I mentioned to you in my letter by the post yesterday. Pitt came back to town last night about nine, and afterwards called here. He had seen all the physicians, and had much conversation with them. They seemed still unwilling, or unable, to decide as to the nature of his disorder; but Warren appeared to incline to the opinion of an ossification. They told him that they had determined, as an experiment, to give the King medicines to remove his fever, in order to observe whether this produced any effect on the state of his mind, and to draw an inference from that whether the disorder on his brain was connected with the fever. They accordingly gave him two doses of James's powder in the course of the day, but without any other effect than lowering his pulse; and this morning we have the severe mortification of hearing that a third dose has operated by a profuse perspiration, so as almost entirely to remove the fever, but that the state of his mind continues unaltered. The physicians, however, all agree that it must still be at least a fortnight before they can venture even to pronounce that it is a disorder of the brain. That even in that case they can give no further opinion; that disorders of that sort are of all others those that are least understood; and that this may continue for many years, or may suddenly leave him, or as suddenly kill him.

I need not tell you the effect which this dreadful calamity produces. Pitt had yesterday a long conference with the Prince; but it turned chiefly on the situation of the King, and the state and progress of his disorder. Nothing passed from which any conclusion can be drawn with respect to future measures. He treated him with civility, but nothing more.

The general idea is that they mean to try a negotiation. But whether the Prince means that, and whether Pitt ought in any case to listen to it at all, or in what degree, are questions which it is difficult indeed to decide. There could never be a more favourable moment for Pitt's leaving the Government, with a view to his own credit and character. But then, on the other hand, his own personal situation must be so embarrassed: there is so much danger of an imputation of pride, and a factious desire of keeping alive differences, that my opinions fluctuate almost from hour to hour. I am still, however, inclined to believe that they will not make the experiment, though the conversation upon it, and the general persuasion of its being intended, make it more difficult for them to avoid doing something of that sort.