| Under 5 years old | 7½ grains. | |
| From 5 to 9 years old | 15 grains. | |
| From 10 to 14 years old | 30 grains. | |
| From 15 to 19 years old | 45 grains. | |
| From 20 to 59 years old | 60 grains. | |
| Above 60 years old | 30 to 45 grains. |
Total dose to be divided into 2 or 3 portions. The patient is allowed to eat only a light luncheon and supper the day of the treatment but the next day he may resume his regular meals.
As a rule most of the worms expelled by the treatment will have been passed by night of the day of treatment, although an occasional one may be passed for four or five days.
In from 25 to 50% of cases all the worms may be expelled in one treatment but it is usually necessary to give as many as 3 treatments, one on each of three Sundays.
Thymol and Beta-naphthol.—Nicol in a comparison of the efficacy of various drugs, noted that thymol in 90-grain doses, taken in 3 portions of 30 grains each, at 6, 8, and 10 A.M. expelled 98% of the worms at the first treatment and the remaining worms at the second treatment a week later. With this rather large dose he frequently observed a tendency to syncope. He used Epsom salts as a purgative.
On the other hand, while using 60 grains of beta-naphthol, given in two portions at 6 and 8 A.M., followed by salts, 86% of the worms were expelled at the first treatment and 14% with the second one. He did not observe any bad effects from beta-naphthol.
The great objection to beta-naphthol is that it is a renal irritant and may damage a kidney already diseased.
Nicol found the treatment with eucalyptus oil, 2 cc., chloroform, 3 cc. and castor oil, 30 cc. vastly inferior in anthelminthic effect to the other two treatments and liable to cause severe manifestations of nausea and syncope.
It is better to divide the dose as just stated into two portions, the second half to be given about one-half hour after the first portion. This reduces the danger from the chloroform.